Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 388
alkaline phosphatase 240
Mol 191
MRI 182
prostate-specific antigen 156
RANKL 141
She 141
parathyroid hormone-related protein 134
FDG 123
RANK 105
PSA 97
MDP 89
collagen 86
type I collagen 84
parathyroid hormone 82
osteosarcoma 82
osteoprotegerin 79
cytokine 72
nodal 62
estrogen receptor 62
prostate specific antigen 61
osteocalcin 61
calcitonin 60
androgen receptor 58
tyrosine kinase 56
HER2 54
vascular endothelial growth factor 52
epidermal growth factor receptor 51
aromatase 48
CEA 48
PC-3 47
PC3 47
acid phosphatase 46
prostate-specific membrane antigen 44
thyroglobulin 41
prostatic acid phosphatase 40
carcinoembryonic antigen 38
somatostatin 37
EGFR 36
tartrate-resistant acid phosphatase 35
p53 35
cathepsin K 34
osteogenic 31
PTH 30
cage 30
osteopontin 29
progesterone receptor 28
OPG 27
MMP-9 26
cytokeratin 26
interleukin-6 26
MET 25
matrix metalloproteinase 24
IL-6 24
interferon 24
mTOR 24
TNM 24
receptor activator of NF-kappaB ligand 23
Men 23
bone) 23
phosphatase 23
E-cadherin 22
ALP 22
hemoglobin 22
vimentin 22
LHRH 22
lactate dehydrogenase 22
endothelin-1 21
chromogranin A 21
bone sialoprotein 21
PSMA 21
CXCR4 21
CA15 20
VEGF 20
p38 20
parathormone 20
type I procollagen 19
CD44 19
CTX 19
Dickkopf-1 19
macrophage colony-stimulating factor 19
rhabdomyosarcoma 19
insulin 18
chemokine 18
tumor necrosis factor 17
Parathyroid hormone 17
Ki-67 17
reserved 17
catenin 17
receptor tyrosine kinase 17
albumin 17
IL-8 17
hormone receptor 17
MMP-2 17
kit 16
caspase-3 15
AKT 15
TGF-beta 15
interleukin-2 15
IL-2 15
ERK 15
IFN 15
CD8 15
noggin 14
neuron-specific enolase 14
sclerostin 14
ATP 13
AMP 13
glycoprotein 13
PI3K 13
Pol 13
TRAP 13
BGP 13
polypeptide 13
PAP 12
LDH 12
TNF 12
C30 12
Rho 12
Mal 12
bone morphogenetic protein 12
synaptophysin 12
Osteocalcin 11
oestrogen receptor 11
bcl-2 11
vascular endothelial growth factor receptor 11
Calcitonin 11
transforming growth factor-beta 11
BRAF 11
urokinase-type plasminogen activator 11
VEGFR2 11
MAPK 11
alpha-fetoprotein 11
DKK1 10
CD20 10
fibronectin 10
mucin 10
ACTH 10
KIT 10
lymphoid 10
serum albumin 10
IL-11 10
ET-1 10
c-Src 10
Met 10
EGF 9
Walker 9
Bcl-2 9
interferon alpha 9
neu 9
p21 9
endothelin A receptor 9
somatostatin receptor 9
RUNX2 9
MMP 9
c-kit 9
BMD 9
platelet-derived growth factor 9
DIC 9
C-reactive protein 9
more...
Disease
bone metastases 6382
cancer 2546
metastases 2424
tumor 1980
breast cancer 1475
prostate cancer 1376
carcinoma 700
hypercalcemia 445
bone disease 390
lung cancer 310
multiple myeloma 275
osteoporosis 263
primary tumor 247
adenocarcinoma 242
spinal cord compression 229
metastatic breast cancer 206
renal cell carcinoma 187
tumor growth 179
liver metastases 171
pathological fracture 157
lung metastases 153
tumor progression 136
melanoma 109
brain metastases 108
hepatocellular carcinoma 97
PSA 97
osteosarcoma 94
non-small cell lung cancer 92
gastric cancer 85
thyroid cancer 84
Prostate Cancer 84
squamous cell carcinoma 75
PDB 73
lung carcinoma 70
neuroblastoma 67
hypercalcemia of malignancy 62
sarcoma 61
prostatic adenocarcinoma 56
anemia 51
bone cancer 47
renal cancer 44
thrombocytopenia 43
tumorigenesis 43
colorectal cancer 40
small cell lung cancer 40
myelosuppression 39
MCF 39
hyperparathyroidism 38
metastatic renal cell carcinoma 37
lymphoma 37
primary hyperparathyroidism 37
carcinoid 36
carcinomatosis 35
disseminated intravascular coagulation 35
aggressiveness 34
carcinoma of the breast 33
Ewing's sarcoma 33
WT1 31
carcinogenesis 31
bladder cancer 30
pheochromocytoma 30
carcinoma of the breast 29
rheumatoid arthritis 27
medullary thyroid carcinoma 27
recurrent breast cancer 27
bone marrow metastases 26
renal failure 25
adenoma 24
solid tumor 24
ductal carcinoma 24
lymphadenopathy 23
colon cancer 22
bronchogenic carcinoma 22
paraganglioma 22
residual disease 22
SCID 21
leukemia 21
neutropenia 21
aggression 20
leukopenia 20
chronic pain 20
neuroendocrine tumor 19
Melanoma 19
hydronephrosis 19
dysplasia 19
rectal cancer 19
CTX 19
diabetes 19
osteomyelitis 19
cold 18
hypertension 18
rhabdomyosarcoma 17
pneumonia 17
depression 17
metastatic melanoma 16
osteoarthritis 16
renal insufficiency 16
osteomalacia 16
pancytopenia 16
ovarian cancer 16
endometrial cancer 15
stromal tumors 15
uterus 15
head and neck cancer 15
heart failure 15
liver cancer 15
Blocking 14
recurrent prostate cancer 14
Osteosarcoma 14
angiosarcoma 14
Osteosarcoma 14
cervical cancer 14
gastrointestinal stromal tumor 13
glioblastoma multiforme 13
chondrosarcoma 13
neuroendocrine carcinoma 13
rare disease 13
renal impairment 13
mammary tumor 13
clear cell carcinoma 13
arterial embolization 13
measurable disease 12
cirrhosis 12
rash 12
FTC 12
leiomyosarcoma 12
paraneoplastic syndrome 12
dysphagia 12
medulloblastoma 11
paraplegia 11
osteosclerosis 11
seminoma 11
periosteum 11
Best 11
skin cancer 11
influenza 11
hemangiopericytoma 11
hormone refractory prostate cancer 11
epithelial ovarian cancer 11
papillary thyroid cancer 11
adenocarcinoma of the lung 11
vitamin D deficiency 10
Hodgkin's disease 10
ureter 10
chronic renal failure 10
PIN 10
clear cell sarcoma of the kidney 10
Neuroblastoma 10
fibrosarcoma 10
Neuroblastoma 10
tumor angiogenesis 10
hyperthyroidism 10
goiter 10
teratoma 9
nerve root compression 9
renal disease 9
NOD 9
transitional cell carcinoma 9
proptosis 9
acute renal failure 9
more...
Symptom
pain 1125
bone pain 422
nausea 54
back pain 54
analgesia 45
cancer pain 42
fatigue 40
headache 37
vomiting 36
dyspnea 34
diarrhea 28
weakness 28
low back pain 26
nausea and vomiting 22
anorexia 20
cough 19
anesthesia 17
collapse 16
cachexia 16
abdominal pain 15
discomfort 13
discomfort 13
chest pain 12
constipation 11
numbness 10
hip pain 8
shortness of breath 8
dizziness 8
breakthrough pain 8
myalgia 8
Ill 7
paresis 7
neck pain 7
hepatomegaly 7
chills 7
erythema 7
shoulder pain 7
epigastric pain 6
tremor 6
hemoptysis 6
sleepiness 6
lethargy 5
polyuria 5
flank pain 5
knee pain 5
arthralgia 5
asthenia 5
hot flashes 5
hypothermia 5
acute pain 5
dysuria 4
paresthesia 4
polydipsia 4
Flare 4
paraparesis 3
flushing 3
dysarthria 3
arm pain 3
spasm 3
pelvic pain 3
splenomegaly 3
exertional dyspnea 3
abdominal fullness 3
respiratory distress 3
ophthalmoplegia 3
abdominal discomfort 3
leg pain 3
leg edema 3
thinning 2
wrist pain 2
productive cough 2
syncope 2
Cushingoid 2
tingling 2
consciousness disturbance 2
halitosis 2
heartburn 2
prostatism 2
sciatica 2
Cushingoid 2
hot flushes 2
urinary frequency 1
heel pain 1
abnormal urination 1
swollen joints 1
ENT 1
bloating 1
non-productive cough 1
carpopedal spasm 1
renal colic 1
ankle pain 1
exhaustion 1
distraction 1
Flaccid paralysis 1
pleuritic chest pain 1
unable to sleep 1
koilonychia 1
left upper quadrant pain 1
Sister Mary Joseph's nodule 1
neurological pain 1
rigors 1
despair 1
Flu-like symptoms 1
otalgia 1
emaciation 1
blurred vision 1
tonic-clonic seizure 1
body pain 1
visual hallucination 1
GI irritation 1
angina 1
abnormal gait 1
fever of unknown origin 1
Pain from metastases 1
dental pain 1
feeling exhausted 1
hemiplegia 1
exertional chest pain 1
Neuropathic pain 1
Severe pain 1
ataxia 1
hepatosplenomegaly 1
lightheadedness 1
Pain symptoms 1
rales 1
hoarseness 1
hunger 1
renal pain 1
vertigo 1
hyperesthesia 1
functional recovery 1
peau d'orange 1
hypoproteinemia 1
spasticity 1
excessive sweating 1
thigh pain 1
seizures 1
jaw pain 1
Drug
Zoledronic acid 154
Zoledronic acid 138
Denosumab 91
EHDP 41
PTH 30
CTX 23
Docetaxel 22
Ibandronate 21
Clodronate 21
APD 19
CTX 19
CTX 19
Adriamycin 18
IL-2 16
Leaf 14
Cardiovasc 13
MAP 13
Aredia 13
SrCl2 12
DMSA 12
CSF 10
ROC 9
IL-11 9
Gefitinib 9
Dermatol 8
ADM 8
CPT-11 8
lysine 7
Imatinib 7
Monit 6
Gallium nitrate 5
Sorafenib 5
ENT 5
ETA 4
Salmon calcitonin 4
HCG 4
ROS 3
Gleevec 3
EPI 3
Bonefos 3
Erlotinib 3
NVP 3
Herceptin 3
Bayer 3
Dasatinib 3
Arimidex 3
Estrogens 3
Estracyt 3
Leucovorin 3
Thyroglobulin 3
Quadramet 3
Vinorelbine 3
Everolimus 3
uPA 3
EE2 3
Estracyt 3
ProstaScint 2
Forskolin 2
Taxol 2
Sandostatin LAR 2
Gel 2
Etoposide 2
Nephron 2
Lipiodol 2
Pertuzumab 2
CTC 2
SrCl2 2
DM1 2
ascorbate 2
ICI 2
G-CSF 2
CPM 2
Diamminedichloroplatinum 2
Paraffin 2
Zoladex 2
Albumin 2
Norplant 2
Gelatin 2
Orion 2
Epidoxorubicin 2
CTC 2
Nephron 2
Bortezomib 2
Zoladex 2
ACT 1
Doxycycline 1
OIF 1
Axitinib 1
Teriparatide 1
Growth hormone 1
Etidronate disodium 1
Cremophor EL 1
Activin 1
Raloxifene 1
Fareston 1
Bevacizumab 1
CA-074 1
Luteinizing 1
Ketorolac 1
Morphine sulfate 1
Angiotensin II 1
Vorozole 1
Mesnex 1
Interferon alfa-2a 1
G418 1
Eptifibatide 1
Glycerol 1
Intron A 1
Casodex 1
Zevalin 1
NAG 1
Lupron 1
TAK 1
Flurbiprofen axetil 1
VCR 1
TAT 1
Ziconotide 1
Prednisone 1
SnF2 1
Percocet 1
ETS 1
VCR 1
Rasburicase 1
Taxotere 1
Sandostatin 1
Dial 1
Intron A 1
LMWH 1
Iguratimod 1
Edatrexate 1
Check 1
Fulvestrant 1
Indomethacin 1
CDP 1
Infliximab 1
Triad 1
NovoSeven 1
Sandostatin 1
Infliximab 1
Intron A 1
Fareston 1
Rasburicase 1
TTC 1
Vandetanib 1
Parnate 1
Simvastatin 1
Roferon A 1
Ipriflavone 1
Spectrum 1
Elcatonin 1
Leukine 1
Ibritumomab tiuxetan 1
Fosamax 1
Award 1
Indocyanine green 1
Dutasteride 1
Navelbine 1
Growth hormone 1
NOV 1
Gelfoam 1
more...
Enzyme
alkaline phosphatase 240
ERK 160
prostate-specific antigen 146
MDP 89
prostate-specific membrane antigen 55
acid phosphatase 46
mitogen-activated protein kinase 35
cathepsin K 34
focal adhesion kinase 31
luciferase 29
lactate dehydrogenase 25
urokinase-type plasminogen activator 13
protein kinase 11
reverse transcriptase 10
MMP 9
caspase-3 9
collagenase 9
MEK 8
ATPase 7
gamma-glutamyl transpeptidase 6
phosphatidylinositol 3-kinase 6
dihydropyrimidine dehydrogenase 6
cathepsin B 6
MMP-3 5
proteasome 5
lysyl oxidase 5
MIP 5
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
PAL 4
trypsin 4
aldehyde dehydrogenase 4
matrix metalloproteinase 9 4
PAL 4
aldehyde dehydrogenase 4
PARP 4
aldehyde dehydrogenase 4
cdc2 4
firefly luciferase 4
thrombin 3
alanine aminotransferase 3
type III procollagen 3
protein kinase C 3
monoamine oxidase 3
diamine oxidase 3
aspartate aminotransferase 3
neuraminidase 3
calcineurin 3
catalase 3
ACS 2
tryptase 2
creatine kinase 2
cathepsin D 2
APC 2
plasmin 2
matriptase 2
CD10 2
IKK 2
ALDH 2
thyroid peroxidase 2
BMT 2
PTR 2
topoisomerase 2
CPM 2
CaMKII 2
sialidase 2
PMT 2
FAST 2
glyceraldehyde-3-phosphate dehydrogenase 2
DNA methyltransferase 2
Thy1 1
lactic acid dehydrogenase 1
phosphoinositide 3-kinase 1
proteinase A 1
HDR 1
neutrophil elastase 1
glyceraldehyde-3-phosphate dehydrogenase 1
phosphoribulokinase 1
succinate dehydrogenase 1
thymidine kinase 1
proline iminopeptidase 1
phosphoglucose isomerase 1
PRA 1
hepsin 1
glutathione S-transferase 1
glycine N-methyltransferase 1
interstitial collagenase 1
chymotrypsin 1
glyceraldehyde-3-phosphate dehydrogenase 1
endothelin-converting enzyme 1
enolase 1
farnesyltransferase 1
sarcosine dehydrogenase 1
CPT 1
choline kinase 1
demethylase 1
farnesyltransferase 1
sphingosine kinase 1
TAT 1
CPT 1
proprotein convertase 1
chaperonin 1
MAT 1
CPT 1
hepsin 1
tissue plasminogen activator 1
TOR 1
SCS 1
lipase 1
BAL 1
BMA 1
PAM 1
collagenase 3 1
caspase-9 1
furin 1
proteinase-3 1
granzyme B 1
proteinase A 1
carboxypeptidase G2 1
NADPH oxidase 1
topoisomerase 1
phospholipase C 1
phosphatidylinositol-4,5-bisphosphate 3-kinase 1
RNase 1
hyaluronidase 1
SPC 1
glyceraldehyde-3-phosphate dehydrogenase 1
phospholipase D 1
prostaglandin synthetase 1
ACE 1
ceruloplasmin 1
arginase 1
RNase 1
tyrosinase 1
prenyltransferase 1
MAT 1
deoxycytidine kinase 1
nucleotidase 1
CPL 1
uridine phosphorylase 1
NADPH oxidase 1
apyrase 1
ribonucleotide reductase 1
lactic acid dehydrogenase 1
PAT 1
21-hydroxylase 1
glyceraldehyde-3-phosphate dehydrogenase 1
matriptase 1
chondroitinase 1
cathepsin G 1
MTD 1
thymidine phosphorylase 1
lactic acid dehydrogenase 1
chondroitinase 1
thymidylate synthase 1
chitinase 1
ADPase 1
pepsin 1
peroxidase 1
Compound
Clin 813
Dec 454
calcium 335
MDA 192
strontium 100
DNA 76
nitrogen 76
creatinine 75
iodine 63
acetate 61
phosphate 61
vitamin D 58
sodium 41
fluorine 37
methionine 37
EHDP 37
tyrosine 36
Pamidronate 35
His 33
water 31
phosphorus 30
Androgen 30
5-FU 30
glucose 26
Adriamycin 26
TNM 24
CTX 23
galactose 22
ALP 22
Docetaxel 21
Thyroid 20
oxygen 16
NH2 16
Asp 15
DTPA 15
cAMP 14
A 71 14
AMP 13
ATP 13
arginine 13
PAP 12
PAP 12
TNF 12
PAP 12
PEG 12
MAP 12
PAP 12
Tamoxifen 11
DIC 11
TSH 11
Progesterone 11
nitrate 11
Tamoxifen 11
Calcitonin 11
MPA 10
lysine 10
Optimal 10
ACTH 10
FTA 10
MPA 10
MPA 10
cysteine 9
CAP 9
PEG 9
BMD 9
CAM 9
aspartic acid 8
CPT-11 8
leucine 8
ADR 8
Gly 8
TPA 8
aspartic acid 8
aspartic acid 8
TPA 8
urea 8
aspartic acid 8
EDTA 8
EDTA 8
zinc 7
Pac 7
VP-16 7
PGE2 7
Gemcitabine 7
sulfate 7
MEK 7
Gemcitabine 7
retinoic acid 7
A 42 6
GTP 6
titanium 6
barium 6
Methotrexate 6
Paclitaxel 6
Estrogen 6
Choline 5
CBDCA 5
TAR 5
acetic acid 5
CBDCA 5
DDP 5
MCA 5
MTX 5
cobalt 5
potassium 5
ASA 5
Estrogen 5
CO2 5
HNO3 5
Vitamin D 5
1,4,7,10-tetraazacyclododecane 5
Alendronate 5
MCA 5
pyridine 5
ADP 5
glutamate 5
25-dihydroxycholecalciferol 4
ethanol 4
Risedronate 4
ETA 4
IMP 4
salt 4
THE 4
copper 4
Cardiol 4
Neuronal 4
Aminoglutethimide 4
proline 4
tin 4
Estracyt 4
Morphine 4
THP 4
Hydroxyproline 4
Bicalutamide 4
Alendronate 4
MMC 4
iron 4
Luminal 4
Dexamethasone 4
Insulin 4
PGE 4
serine 4
Octreotide 4
BCG 4
BAP 4
6-12 4
aluminum 4
Estracyt 4
ADP 3
THP 3
Toremifene 3
MTT 3
folinic acid 3
Tegafur 3
Leucovorin 3
GAL 3
Tegafur 3
tryptophan 3
Phe 3
ADP 3
more...