Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0153690 (
bone metastases
)
6,382
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In mice, the lack of
secreted frizzled-related protein 1
(
SFRP1
) is responsible for mammogenesis and hyperplasia, while, in bovines, its overexpression is associated with post-lactational mammary gland involution. Interestingly, there are no reports dealing with the role of
SFRP1
in female involution. However,
SFRP1
dysregulation is largely associated with human tumorigenesis in the literature. Indeed, the lack of
SFRP1
is associated with both tumor development and patient prognosis. Considering the increased risk of breast tumor development associated with incomplete mammary gland involution, it is crucial to demystify the "grey zone" between physiological age-related involution and tumorigenesis. In this review, we explore the functions of
SFRP1
involved in the breast involution processes to understand the perturbations driven by the disappearance of
SFRP1
in mammary tissue. Moreover, we question the presence of recurrent microcalcifications identified by mammography. In
bone metastases
from prostate primary tumor, overexpression of
SFRP1
results in an osteolytic response of the tumor cells. Hence, we explore the hypothesis of an osteoblastic differentiation of mammary cells induced by the lack of SFRP1 during lobular involution, resulting in a new accumulation of hydroxyapatite crystals in the breast tissue.
...
PMID:Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment. 3194 16
