Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0153690 (
bone metastases
)
6,382
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Molecular and functional mechanisms of
bone metastases
were poorly understood. This study was to screen out differentially expressed genes (DEGs) and functional proteins in
bone metastases
from lung for better understanding of the molecular and functional mechanisms. Our results suggested CTSS, CTSD, MX1,
NKX2-1
might play a decisive role in bone metastasis. Collectively, these results demonstrated that bone metastasis from lung cancer would lead to changes in lysosome function, which may affect the decomposition and elimination of old bone matrix, thus affecting bone turnover. In addition, our findings provided new insights into the prediction and treatment of
bone metastases
.
...
PMID:Downregulation of lysosomal and further gene expression characterization in lung cancer patients with bone metastasis. 2768 53
