Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cervical uptake detected by 131I whole body scintigraphy (131I-WBS) may be due to thyroid remnants or loco-regional metastases. We describe a patient with follicular carcinoma submitted to total thyroidectomy. 131I-WBS showed left cervical linear uptake and focal areas of uptake in the abdomen and pelvis. SPECT/CT images demonstrated a potential thrombus in the left jugular vein (confirmed by doppler neck ultrasound and MRI) as well as bone metastases. The patient was submitted to thrombectomy and histopathology confirmed metastasis of follicular carcinoma.
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PMID:Follicular thyroid carcinoma metastasis to the internal jugular vein demonstrated by 131I SPECT/CT. 2456 19

In this paper we report on a successful management of multiple bone metastases from differentiated thyroid cancer. In 2007, a 75-year-old female patient, previously referred for thyroidectomy for multinodular goiter, underwent surgical removal of a lumbar mass with histological findings of metastasis from well differentiated thyroid cancer. After surgery, serum thyroglobulin (sTg) was 204.4 ng/mL. A diagnostic/dosimetric (123)I WBS was performed, following stimulation by rTSH. Serial WBSs were acquired, along with SPECT/CT and bone scan for localization of lesions. sTg raised to 3.810 ng/mL, and (123)I WBS showed thyroid remnants and numerous areas with high iodine-uptake corresponding to skeletal sites, the two largest loading on the skull, with osteolytic pattern. Calculated radiation absorbed dose for skull lesions, determined by mean of MIRD methodology, was 63.5 mGy/MBq. The patient underwent surgical removal of the two major skull lesions. Successively, 100 mCi (131)I was administered after stimulation by rTSH, with stimulated sTg 297 ng/mL. After 8 months, diagnostic WBS was negative both for remnants and metastases and rTSH-stimulated Tg was 0.6 ng/mL. To date, the patient has maintained sTg values <1 ng/mL during L-T4 suppressive therapy and after rTSH stimulations. In this unusual case of extensive bone cancerous involvement with high iodine avidity, a multidisciplinary approach based on surgery and dosimetry-guided radiometabolic therapy allowed to accurately assess the patient, execute a small number of treatments and achieve a complete remission of the disease in a very short time, with no additive morbidity.
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PMID:Disseminated bone metastases from occult thyroid cancer effectively treated with debulking surgery and a single dosimetry-guided administration of radioiodine. 2545 5

Based on the PETCT image segmentation algorithm, this paper explores the application of PET/CT in the recurrence and metastasis of thyroid cancer after differentiated thyroid cancer (DTC). In this study, 132 patients with DTC combined with 131 I treatment underwent PET/CT whole body imaging and 131 I whole body scan (131 I-WBS), and the serum thyroglobulin (Tg) was measured at the same time. Results Among 54 Tg-positive patients, 49 were positive for 131 I-WBS and 32 were positive for PET/CT imaging. Of the 15 Tg-negative patients, 131 I-WBS and PET/CT imaging were negative. 3 cases with 131 I-WBS suggesting residual thyroid tumours are all positive in PET/CT examinations; 7 cases with 131 I-WBS suggesting lymph node metastasis are all positive in PET/CT examinations, and in 131 I -PET/CT imaging in WBS-negative patients revealed 6 lung metastases and 3 bone metastases. PET/CT and 131 I scan are roughly the same in the diagnosis of residual thyroid and lymph node metastasis, but PET/CT has more advantages than 131 I scan in the diagnosis of bone metastasis and lung metastasis. PET/CT can still find other benign and malignant lesions, which is of great value in the restaging of DTC. The imaging effect of WBS lung lesions in older patients is not good. The presence of stripe, calcification, and patch shadows in the lungs is not conducive to the imaging of WBS lung metastases. Lung strips and calcification affect the WBS lung Main factors for imaging of metastases.
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PMID:Treatment of Differentiated Thyroid Cancer and Recurrent Laryngeal Nerve Function with 131 Iodine Based on PET / CT Image Segmentation Algorithm. 3316 89