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Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although peripheral metastases of many malignancies to bone are common, metastases to the hand and carpus are rare. This is the first report of a silent primary malignancy of the lung presenting as a metastasis to the carpal navicular bone. Only eight instances of carpal bone metastases secondary to all tumor sources were revealed in a search of the literature. The presentation of metastatic disease in the hand in an occult malignancy may be deceptive, often mimicking pulp space infection, osteomyelitis, septic arthritis, gout, acute rheumatoid monoarticular arthritis, tenosynovitis, or sympathetic dystrophy. These lesions often present as radiolucent lesions; histologic findings are consistent with the tumor of origin. Treatment is palliative and consists of resection or amputation. Radiotherapy should be avoided in the hand due to secondary fibrosis and scarring.
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PMID:Presentation of malignancy by metastasis to the carpal navicular bone. 646 20

Early proper diagnosis of non-Hodgkin's lymphoma is critical. However, without a high index of suspicion, the diagnosis can often be missed because of the nonspecific symptoms and normal plain radiographs. Further, non-Hodgkin's lymphoma can be misdiagnosed as an infectious condition - such as osteomyelitis or septic arthritis - or as an inflammatory disease. The authors report a case of mature B-cell lymphoma of the small intestine or colorectal primary malignancy with peritoneal seeding and multiple bone metastases in an 8-year-old boy. This case report emphasizes the importance of a comprehensive approach with patients, including children with nonspecific symptoms, to orthopedic surgeons.
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PMID:Lymphoma with unusual manifestations resembling acute osteomyelitis in bilateral ankles of an 8-year-old boy: a case report. 2391 7