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Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nonparathyroid humoral hypercalcemia is becoming an increasingly more common problem associated with carcinoma. Carcinomas of the head and neck may elaborate parathormone or parathormone-like humors that in the absence of bone metastases, renal disease, parathytoid tumors, or secondary hyperparathyroidism may produce hypercalcemia, which if unrecognized, complicates and prevents the appropriate management of the patient. This report deals with the production of parathyroid hormone and the first reported case, to our knowledge, of carcinoma of the larynx associated with nonparathyroid hypercalcemia.
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PMID:Production of parathyroid hormone by laryngeal cancer. Report of a case. 114 29

A hydroxylapatite assay was used to assay androgen receptor levels in 23 primary laryngeal carcinomas, nine metastatic laryngeal carcinomas, and three oropharyngeal carcinomas. The median androgen receptor level in laryngeal carcinoma was 0.7 femtomoles of receptor protein per milligram of cytosol protein. Ten patients with advanced or metastatic laryngeal carcinoma and one patient with metastatic floor of mouth carcinoma were treated with the antiandrogen flutamide. There were three short-lived partial responses (1, 2, and 2.5 months) in nine patients whose tumors could be evaluated for response. Toxic reactions consisted of mild breast tenderness, and hypercalcemia in two patients with bone metastases. Androgen receptor levels did not correlate with response to flutamide. The low androgen receptor levels in laryngeal tumors may account for the relative inactivity of the antiandrogen in laryngeal cancer.
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PMID:Androgen receptors and antiandrogen therapy for laryngeal carcinoma. 638 37

Four patients are described with distant bone metastases from primary squamous-cell carcinoma of the larynx. In one case the metastases were osteosclerotic, a previously unreported occurrence. The metastases were osteolytic in the other three patients. Bone metastases from laryngeal carcinoma are rare and associated with locally extensive tumours and a poor prognosis.
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PMID:Bone metastases from squamous-cell carcinoma of the larynx. 687 53

To arrive at a reasonable estimate of the total need for radiotherapy, the various descriptions of population trends and measures of cancer trends must be studied concurrently. Incidence and mortality are well documented by official statistics. All prognoses are based on these measures, the official population statistics, and the 1989 population prognosis from Statistics Sweden. Incidence, mortality, and prevalence may be considered either individually or together as indirect measures of the need for radiotherapy at different stages for different types of cancer. Incidence, ie, the number of cases of disease onset during a given period, shows the indirect need for curative radiotherapy, eg, for breast cancer, laryngeal cancer, gynecological tumor types, and head and neck cancer. The projected average annual mean increase in total incidence is 1.0%. Mortality may be used as an indirect measure of the need for palliative treatment for recurring cancer, eg, for bone metastases, prostate cancer, lung cancer, or breast cancer. The mean increase is estimated at 0.9% per year. Likewise, prevalence can be an indirect measure of the need for palliative treatment for cancer diseases of a chronic nature, eg, prostate cancer and multiple myeloma. The total mean increase per year has been estimated at 2.0%. The total need for radiotherapy in the future should be viewed against the background of all these descriptive measures. Assessment must also consider numerous other factors that directly influence need. A change in the indications for treatment can quickly increase the need for radiotherapy, eg, the benefits of radiotherapy for noninvasive breast cancer are currently being studied. Even a change in the indications for surgical intervention for small tumors in the breast influence the need for primary curative radiotherapy in this large group of patients. Likewise, a shift in staging the primary diagnosis, eg, in head and neck cancer, and changes in fractionation (hyperfractionation) may substantially influence need. This is addressed further in another section of the report. The largest single group of cancer patients who receive radiotherapy are those with bone metastases (25% of the total). The size of this group, and thereby the potential unsatisfied need, is largely unknown since no statistics show the prevalence of metastases in the population. This group is comprised mainly of patients that were primarily diagnosed with prostate cancer, breast cancer, and lung cancer. Concerning lung cancer, incidence trends probably provide the best measure of changes in the number of bone metastases over time. The annual increase in incidence has been estimated at 1.5%. As for breast cancer and prostate cancer, mortality trends provide more information about trends in the number of bone metastases. Both types of cancer increased by 1.9% per year. Chapter 6 presents the types of cancer for which radiotherapy is usually given. The projected trends show that each of these cancer diagnoses, except lung cancer in men and cervical cancer in women, are expected to increase in number until the year 2010. Prevalence is expected to increase even more, particularly cancer in the rectum, breast, and prostate. Also, the number of cases of non-Hodgkin's lymphoma is expected to nearly double by 2010.
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PMID:Cancer trends in Sweden until 2010. 915 84

A rare case of distant metastasis to spinal column--lumbar vertebra (L5)--from laryngeal cancer was reported. It must be noted that in 10% of cases metastases to vertebral column are first symptom of a neoplastic disease and sixty-five percent of patients with advanced cancer present bone metastases. Metastatic involvement of the bone is one of the most frequent causes of pain in cancer patients and represents one of the first signs of widespread neoplastic disease. Nevertheless metastases to lumbar vertebral column from laryngeal cancer is very rare. In presented case MRI and CT were performed to confirm metastasis. Laryngological examination revealed tumor of a right part of larynx--squamous cell carcinoma (G2) in histopathological examination. The patient was qualified to palliative radiotherapy and still is under laryngological observation.
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PMID:[The rare case of metastasis to lumbar part of spinal column from laryngeal cancer]. 1920 34