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Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Percutaneous vertebroplasty is a minimally invasive procedure that is effective in the treatment of pain resulting from pathologic compression fractures, osteolytic bone metastases from solid tumors, myeloma, vertebral hemangioma, and osteoporotic compression fractures. A discussion of a patient with severe, aggressive metastatic breast cancer to the spine with compression and osteolysis of multiple lumbar vertebral bodies is presented. Despite treatment with opiates, chemotherapy, radiation therapy, and the implantation of a morphine pump, her pain was not adequately treated until she underwent multilevel vertebroplasty. The clinical and technical application of vertebroplasty in the context of the management of vertebral pain of malignant origin is presented as an integral part of multidisciplinary pain management.
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PMID:Percutaneous vertebroplasty in the management of a patient with malignant pain and associated osteolytic compression fractures. 1241 2

Radiation can be shown to produce satisfactory results in the treatment of simple bone cyst, chondroma, angioma, and benign giant-cell tumour. It is of particular value in benign giant-cell tumour where there are grounds for the opinion that it should largely replace surgical methods.Surgery remains the methods of choice in the treatment of osteogenic sarcoma but where the lesion is inaccessible growth restraint may be obtained by the use of X-ray therapy.Radiation, as a palliative measure, is of definite value in the treatment of bone metastases.Myelomata are uniformly responsive to X-ray therapy, which is capable of prolonging life and relieving pain in these cases.It is probable that radiation therapy is superior to surgery in treatment of Ewing's tumour if the diagnosis be made at an early stage of the disease.Direct invasion of the bone by tumour should not be considered a contra-indication to radiation therapy, particularly if the tumour is of a type known to be radio-sensitive.
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PMID:Radiation Therapy in Tumours of Bone: (Section of Radiology). 1999 47

Objective. To present a complicated case of differentiated thyroid carcinoma (DTC) with metastases to the skull that was evident on I-131 whole body scan (WBS) but negative on other imaging modalities in a low risk patient. Methods. We will discuss clinical course, imaging, pathological findings, and treatment of the patient with skull metastasis from DTC. Pertinent literature on imaging and pathology findings as well as radioactive iodine (RAI) treatment impact on quality of life and survival in patients with bone metastases from DTC will be reviewed. Results. The patient is a 37-year-old woman with a diagnosis of DTC who had focal areas of increased uptake in the head on WBS with no correlative findings on CT and MRI. Initially, false positive findings were suspected since patient had a low risk for developing metastases. However, the persistent findings on post-RAI treatment WBS, following two courses of treatment, were highly concerning for metastatic bone disease. WBC performed 6 months following the second RAI treatment revealed resolution of the findings. Conclusions. False positive findings in WBS are frequent and may be due to contamination, perspiration, or folliculitis of the scalp as well as benign lesions such as meningioma, hematoma, cavernous angioma, and metallic sutures. However, metastatic disease should always be considered even if the patient has low risk of distant metastatic disease and correlative images do not support the diagnosis. RAI therapy appears to improve the survival rates and quality of life of thyroid cancer patients with bone metastases based on retrospective studies.
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PMID:Unexpected Bone Metastases from Thyroid Cancer. 2623 12