Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Complications due to cancer and its treatment are common and increase in incidence and severity as the disease progresses. Central nervous system complications affect 15% to 20% of patients, and up to 75% have bone metastases at some point during the disease process. Endocrine abnormalities include hypercalcemia, adrenal insufficiency, and inappropriate antidiuretic syndrome. Hematologic disorders, malignant effusions, and gastrointestinal (GI) problems may cause significant morbidity.
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PMID:Common complications of advanced cancer. 1069 20

Hypercalcaemia is a well-recognised feature of hypoadrenalism. The adrenal glands are often involved with metastatic disease subclinically although full hypoadrenal crisis is not uncommon. Ill patients with known malignancy should generate a high degree of clinical suspicion for the possibility of adrenal involvement. This case highlights the need to look beyond confirmed bone metastases as the cause of hypercalcaemia in patients with widespread carcinomatosis.
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PMID:Hypercalcaemia of hypoadrenal crisis mistaken for hypercalcaemia of malignancy in a patient with known bone metastases: a case report. 1111 62