Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0153640 (
Cerebellum
)
1,777
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
Rhodamine B is a component of xenobiotic substance metabolized by cytochrome P450 in the body to produce free radicals, which affects the activity of Superoxidase Dismutase (SOD), thereby, leading to oxidative stress, injury, increase in cell apoptosis and brainstem. This study aims to determine the effect of Rhodamine B on
BAX
and BCL-2 in the cerebellum and brainstem tissue of
Rattus norvegicus
.
Design and Methods:
The True Experimental Design was used to carry out a post-test examination on the control group of twenty-eight Wistar female
Rattus norvegicus
mice between the ages of 10-12 weeks. Then, samples were categorized into 4 groups in body weight doses of 4.5 mg/200g, 9 mg/200g, and 18 mg/200g. They were administrated with Rhodamine B personde for 36 days.
Results:
The results showed that Rhodamine B had a direct and indirect effect on
BAX
and BCL-2 expressions, respectively, in the cerebellum tissue and wistar strain of
Rattus norvegicus
. In addition, the positive path coefficient of
BAX
expression has a positive effect on BCL-2. This means that an increase in
BAX
has a direct impact on decreasing BCL-2 expression in cerebellum tissue and brainstem of
Rattus norvegicus
wistar strain along with an increased dose of Rhodamine B.
Conclusions:
In conclusion, Rhodamine B tends to increase
BAX
expression which directly decreases BCL-2 in
Cerebellum
tissue and Brainstem in
Rattus norvegicus
along with increasing doses.
...
PMID:The effect of Rhodamine B on the cerebellum and brainstem tissue of
Rattus norvegicus
. 3272 58
