Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153470 (Spleen)
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Human Gene/Protein
Chitinase 3-like 2 13.0
B-cell receptor-associated protein 29 13.0
PLC-IV 11.4
DEFB29 10.4
Allograft inflammatory factor 1 10.4
TRGV9 10.1
MGA protein 10.1
Septin-2 10.0
FHOS 10.0
CAB39L 9.8
AQR 9.6
iron-sulfur protein 3 9.5
20-alpha-hydroxysteroid dehydrogenase 9.4
APG1 9.3
NS-1 9.1
AB6 9.0
p47 protein 8.9
ZC3HAV1 8.9
STX3 8.8
AG8 8.6
FCRL 8.6
TARS 8.5
HOX-11 8.5
TDRD7 8.4
CTIP 8.4
SP2 8.4
3G2 8.4
LY6E 8.4
SRBC 8.2
ORAI2 8.2
LR8 8.2
NDR2 8.1
FBL 8.1
SLC7A6 8.0
ISG12 8.0
CAK1 8.0
MST-1 8.0
skeletrophin 8.0
TYH 7.9
testis protein 7.9
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Disease
Spleen 13.0
Mediterranean macrothrombocytopenia 11.4
infection; spleen 11.0
Leishmania tropica infection 9.8
Hemorrhagic enteritis 9.5
Functional asplenia 9.3
Overwhelming post-splenectomy infection 9.1
Granulocytosis 9.1
hyperchromic anemia 9.0
Post-weaning multisystemic wasting syndrome 9.0
Oropouche fever 8.9
Small Intestine 8.7
Radiation Syndrome 8.6
perisplenitis 8.6
ABO hemolytic disease 8.4
Wound sepsis 8.2
FBL 8.1
Inhalational anthrax 8.0
Gallbladder disease 8.0
Landouzy 8.0
blind loop syndrome 7.9
onychogryphosis 7.9
Gamna 7.9
Stomach 7.8
Stomach 7.8
Stomach 7.8
white leg 7.8
Stomach 7.7
Friend leukemia 7.6
Thalassemia intermedia 7.5
Littoral cell angioma 7.4
bacterial dysentery 7.2
Thymus 7.2
Thymus 7.2
Thymus 7.2
Subclinical infection 7.1
T/NK-cell lymphoma 7.1
B-cell prolymphocytic leukemia 7.1
Theileriosis 7.0
Splendore-Hoeppli phenomenon 7.0
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Symptom
Skin thickening 8.6
Ear swelling 8.0
chromosome marker 7.4
eye discharge 6.9
splenomegaly 6.5
Crawling 6.4
abnormal breathing 6.2
prostration 5.4
lassitude 4.8
hepatomegaly 4.3
asthenia 4.2
loss of balance 4.1
hepatosplenomegaly 4.0
Decreased activity 3.9
HSA 3.7
pallor 3.7
lethargy 3.5
consciousness disturbance 3.3
incoordination 3.2
hypoproteinemia 2.8
decreased appetite 2.8
night sweats 2.7
Wind 2.6
anorexia 2.4
acute stress 2.4
acute abdomen 2.4
bone pain 2.3
enuresis 2.3
abdominal discomfort 2.2
abdominal pain 2.1
cyanosis 2.1
cachexia 2.1
acute abdominal pain 2.0
exhaustion 1.8
tachypnea 1.6
diarrhea 1.6
cancer pain 1.4
functional recovery 1.2
epigastric pain 1.2
cerebellar ataxia 1.1
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Drug
Buspar 8.3
Lomotil 7.7
AKM 7.1
Meth 6.9
Ceredase 6.8
Velban 6.7
Pentostam 6.6
Thymopentin 6.6
Coconut oil 6.3
Cerezyme 6.3
Syrup 6.2
Rhubarb 5.9
Span 20 5.9
Podophyllotoxin 5.9
Xanthan gum 5.8
IFN-gamma 5.7
Lead acetate 5.6
CET 5.6
Span 60 5.6
Podophyllum 5.6
IL-2 5.5
Casodex 5.4
Cetrorelix 5.4
Novantrone 5.3
BLyS 5.3
Mitomycin-C 5.3
LCM 5.2
LCM 5.2
Hypaque 5.2
BCG vaccine 5.1
Ammonium chloride 5.1
Glucantime 5.1
Hypaque 5.0
Thyroglobulin 5.0
Desferal 5.0
RAL 5.0
CDX 5.0
Cellulose acetate 4.9
RbCl 4.9
RbCl 4.9
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Enzyme
retinal oxidase 8.9
deoxyadenosine kinase 7.5
MSAS 7.1
leishmanolysin 6.7
phosphatidylinositol phospholipase C 6.4
TDH 6.2
homoserine kinase 5.9
Thy1 5.9
TSR 5.5
cruzipain 5.2
estrogen sulfotransferase 5.0
bromelain 5.0
orotate phosphoribosyltransferase 4.6
nucleotide pyrophosphatase 4.4
dextranase 4.3
3'-exonuclease 4.3
factor D 4.2
SCP 4.1
proton-translocating ATPase 4.1
prostaglandin synthetase 4.1
purine nucleoside phosphorylase 4.1
endo-beta-galactosidase 4.0
aldehyde reductase 3.9
p80 3.9
PI-PLC 3.8
CCS 3.7
TSA 3.7
phenylethanolamine N-methyltransferase 3.7
tissue kallikrein 3.7
branching enzyme 3.7
AMP deaminase 3.5
dopamine beta-hydroxylase 3.5
deoxycytidine kinase 3.5
glucocerebrosidase 3.4
deoxyribonuclease 3.4
MAT 3.4
deoxyribonuclease 3.4
TMT 3.3
galactose oxidase 3.3
TSP-1 3.2
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Compound
o-Nitrochlorobenzene 12.0
3-Methylthiopropionate 11.4
butanal oxime 10.1
methyl mercaptoacetate 9.8
PNCB 9.5
2-butanone oxime 9.4
TMCA 9.0
Chlorozotocin 8.8
Origen 8.6
TMCA 8.6
beta-Ionone 8.6
Oxymetholone 8.4
beta-Ionone 8.2
KI3 8.1
o-benzyl-p-chlorophenol 8.1
2,5-hexanediol 8.0
PC-5 8.0
Cocaine hydrochloride 7.9
Mafosfamide 7.6
Leucine enkephalin 7.4
MIF-I 7.3
Picric acid 7.1
DT3 7.1
1-phenyl-1,2-ethanediol 7.1
Velban 7.0
Dicofol 7.0
Perillyl alcohol 6.9
Perillyl alcohol 6.9
TCM 6.9
TCM 6.9
Linuron 6.8
Tilorone 6.8
Pristane 6.8
X 13 6.7
Thiamphenicol 6.6
Paraformaldehyde 6.6
DBA 6.5
DBA 6.5
DNP 6.5
20-COOH-LTB4 6.5
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