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Enzyme
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Target Concepts:
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Enzyme
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Query: UMLS:C0153470 (
Spleen
)
4,015
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Spleen
cell suspensions of 2 dialysis patients with hepatosplenomegaly and pancytopenia were studied in vitro.
Spleen
cells of a cadaver kidney donor were studied as control. In spleen macrophages of the patients, silicone particles could be demonstrated with
TEM
and electron microprobe analysis. Under basal conditions and after stimulation with zymosan and concanavalin A, release of PGE2, TXB2 and 6-keto-PGF1 alpha from patient cells was higher than control cells. This anecdotal observation parallels previous animal studies and suggests that loading of human macrophages with foreign material particles activates arachidonic acid metabolism.
...
PMID:Evidence for macrophage activation in dialysis patients exposed to silicone filing. 398 82
In this study, Sprague-Dawley rats were exposed in a
TEM
chamber to 20-MHz (HF-band) continuous-wave radiofrequency radiation (RFR) for 6 hr/day, 5 days/week up to 6 weeks. The average E-field intensity was 2686 +/- 164 V/m (mean +/- SD) and the calculated specific absorption rate was 0.3 W/kg. Randomly sampled rats killed on Days 8, 22, 39, and 42 after initiation of exposure showed no statistically significant differences from controls for body mass, spleen cell density, erythrocyte and leukocyte counts, hematocrit, hemoglobin, methemoglobin, erythrocyte fragility, bilirubin, creatinine, SGPT, alkaline phosphatase, calcium, sodium, potassium, and spleen cell chemiluminescence. Splenic mass differences were statistically significant (p less than 0.05) only on Day 22.
Spleen
to body mass ratios differed significantly between exposed and control groups on Days 22 and 39 (P less than 0.05 and P less than 0.025, respectively). Histologic examination of the rats revealed the successive accumulation of phagocytic cells, lymphoid proliferation, development of lesions, and tissue necrosis characteristic of respiratory mycoplasmosis. In a followup experiment, a separate set of rats was exposed for 6 weeks to identical levels of RFR. No significant differences were found in splenic parameters and spleen cell peroxidative activity. Histologic examination of these animals revealed no evidence of mycoplasma infection. The observed differences between exposed and control animals of the first experiment appear to have resulted from subclinical respiratory mycoplasmosis rather than exposure to RFR.
...
PMID:Effects of 20-MHz radiofrequency radiation on rat hematology, splenic function, and serum chemistry. 402 74
Xiang-sha Warming (XSW) and Shashen Nourishing Decoction (SSN) were used in treating Yang Deficiency Syndrome (YaDS) and Yin Deficiency Syndrome (YiDS) of chronic atrophic gastritis (CAG) respectively. 121 cases with
Spleen
YaDS, and 29 cases with
Spleen
YiDS were selected. 26 and 30 specimens were taken from gastric mucosa for observation under the SEM and
TEM
, including 12 and 12 YaDS cases, 14 and 12
Spleen
Qi Deficiency cases respectively, 2 cases of YiDS were also observed with
TEM
. The specimens were taken from the same site of the gastric mucosa directly under the gastroscope pre- and post-treatment. 43 patients (35.6%) with spleen YaDS and 5 cases (17.2%) in
Spleen
YiDS showed marked effect after 3-month treatment. It showed that the effect in
Spleen
YaDS was better than YiDS. The XSW was superior than that of SSN. The effects were related to the syndromes and the degrees of pathologic change. This showed that the recipe could somewhat reverse and restore the abnormal glands of gastric mucosa.
...
PMID:[Pathomorphologic changes on 150 chronic atrophic gastritis patients by treatment based on syndrome differentiation]. 833 30
Background:
As a promising nanomaterial for biomedical applications, zirconia nanoparticles (ZrO
2
) have aroused concern recently, but the toxicity of ZrO
2
in vivo has received little attention.
Purpose:
The aim of this study is to demonstrate the systematic single dose toxicity, biodistribution and oxidative damage of ZrO
2
in vivo after intravenous injection in mice.
Materials and methods:
Ten ICR mice were used at the high dose of ZrO
2
including 600, 500, 400 and 300mg/kg. Maximum tolerated dose (MTD) of 150 nm ZrO
2
was determined as 500mg/kg. Hematology analysis and blood biochemical assay were determined for the evaluation of oxidative damage caused by ZrO
2
. Biodistribution of ZrO
2
was investigated by ICP-OES and
TEM
.
Results:
Mice treated with higher dose (500mg/kg) showed significant spread in white blood cell counts (
p
<0.05). Especially, the serum ALT levels of 500mg/kg groups increased significantly (
p
<0.05) compared with the control group. ZrO
2
particles would not induce any changes in appearance and micromorphology of liver at 100 and 350mg/kg.
Spleen
samples showed no significant changes in micromorphology of the lymphoid follicles and in the size of the red pulp after injection of ZrO
2
at all doses. The serum of ZrO
2
-treated animals (350 and 500mg/kg) has reduced levels of SOD compared to the control group (
p
<0.05). ZrO
2
persists in membrane-enclosed vesicles called lysosomes in the liver and spleen macrophages without abnormal changes of ultrastructure.
Conclusion:
These findings would contribute to the future development of ZrO
2
-based drug delivery system and other biomedical applications.
...
PMID:Toxicity, biodistribution and oxidative damage caused by zirconia nanoparticles after intravenous injection. 3140 86
