Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153470 (Spleen)
 4,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma of cAMP and cGMP in 30 cases of chronic active hepatitis (group of cholestatic patients) as well as in 20 cases of chronic hepatitis with submassive or massive necrosis (group of chronic severe hepatitis patients) were studied with 125I-marked radioimmunoassay. 50 cases with their serum bilirubin levels higher than 171 mumol/L were selected as subjects for this study. Among them, 42 were diagnosed as hepatitis B, 6 as coinfection of hepatitis A and B. According to differentiation of symptoms and signs of TCM, 24 were diagnosed as simple hepatitis due to blood stasis and blood heat, 17 as hepatitis due to blood stasis and blood heat accompanying symptoms of Yang deficiency of the Spleen and Kidney. 20 healthy persons were selected as controls. The results were as follows: cAMP was 56.82 +/- 25.54 ng/L and 80.32 +/- 20.73 ng/L, and cGMP was 9.07 +/- 6.56 ng/L and 19.49 +/- 9.34 ng/L in the group of cholestatic patients and in the group of chronic severe hepatitis patients respectively. Both were higher than those in the control group whose cAMP was 14.12 +/- 3.25 ng/L and cGMP was 5.87 +/- 1.44 ng/L (P less than 0.01). Increase in cGMP and decrease in the ratio of cAMP and cGMP in the cases accompanying symptoms of Yang deficiency of the Spleen and Kidney were much higher than those in the other two types of hepatitis patients (P less than 0.01 and 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Relation of changes in plasma cAMP, cGMP and the clinical conditions, pathology and the type of traditional Chinese medicine in 50 cases of chronic severe icteric hepatitis]. 216 73

According to this study, the immunological function was aberrant in cancer patients with Spleen-deficiency syndrome. The TII cell in normal persons (n = 26) was 30, 86 +/- 9.70% (means +/- S) and in these cases (n = 43) was 22.62 +/- 9.92%, P less than 0.002. The cytotoxicity of NK cell in patients (n = 59) was 17.65 +/- 10.58%, in normal controls (n = 43) was 25.51 +/- 14.10%. The combining ability of NK cell in patients (n = 48) was 39.11 +/- 19.43%, the normal persons (n = 41) was 55.88 +/- 17.94%. It showed that the immune function of the cancer patients with Spleen-deficiency syndrome were markedly lower than that of normal persons. The serum IgA in saliva of patients (n = 37) was 0.44 +/- 0.17 microgram/ml. It was much higher than that of normals' (n = 24, 0.30 +/- 0.06 microgram/ml), P less than 0.001. Some patients' NK cell function and the level of level of SIgA in saliva were recovered to normal after treatment of Shengxue Tang which could strengthen the Spleen and replenish the Kidney. These studies proved that the TCM played an important role for modulating immune function in treating cancer patients.
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PMID:[Immune function of cancer patients with spleen-deficiency syndrome]. 226 41

This study observed the effect of chemotherapy combined with Chinese herbs and western drugs on white blood cell count in 31 patients with gastric cancer. These patients were divided into 3 groups: (1) Fu Zheng (strengthen the body resistance) with invigorating the Spleen and Kidney recipe; (2) Fu Zheng with western drugs raising WBC and enhancing immunity; (3) Gong Xiao (eliminating the evil factors and mass) with promoting blood circulation to remove blood stasis recipe or eliminating the evil factors and mass recipe. After chemotherapy, the mean of WBC count was greater than 4.0 X 10(9)/L in group I; less than 3.5 X 10(9)/L in group II; less than 3.0 X 10(9)/L in group III. Because of WBC count below 3.0 X 10(9)/L, in group II there were 5 cases (5/14) whose chemotherapies had to be discontinued, and in group III there were 4 cases (4/6). While all patients were completed their chemotherapies in group I. Its statistical difference was significant (P less than 0.05). It suggested that invigorating the Spleen and Kidney recipe had specific effect on decreasing the toxicity and side effect of chemotherapy, preventing bone marrow suppression and leukopenia, and was better than western drugs used in group II. It showed in the treatment of cancer with TCM, we must pay attention to the relationship between the Fu Zheng and the Gong Xiao.
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PMID:[Clinical effect of chemotherapy combined with Chinese herbs and western drugs on leukocytes of gastric cancer patients]. 229 16

The Spleen-Stomach theory is an important component of the theories of TCM. Exploration of pathophysiologic changes in patients with Stomach Yin Deficiency Syndrome (SYDS) is of help in explaining the Spleen-Stomach theory. Hence patients with SYDS due to abdominal operation or severe acute abdominal diseases were selected as objects to be observed. The endotoxin in plasma, immune function of the body, the mean temperature and blood perfusion rate at the centre of the tongue, area representing the Spleen and Stomach, the surface pH and index of electric conduction of the tongue and rheologic changes were determined. The results showed that the content of plasma endotoxin in patients with SYDS was 346 +/- 216 ng/ml (mean +/- SD). The value in all patients with SYDS was beyond normal (50 ng/ml), the highest being 1050 ng/ml. ANAE and LTT were decreased, as compared to the control (P less than 0.001). The content of IgG, IgA, CIC in blood increased (P less than 0.05, P less than 0.001, and P less than 0.001 respectively), and that of IgM decreased (P less than 0.002). The consistency of C3 in patients with SYDS was 83.6% of the control (P less than 0.001), and that of C4 and C5 increased (P less than 0.01 and P less than 0.001 respectively). The mean temperature of the tongue with SYDS was 0.64 degrees C lower than the control (P less than 0.05) and the blood perfusion rate was decreased 16.4% than the control (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Research on stomach yin deficiency syndrome due to abdominal surgery or severe acute abdominal diseases (I)]. 235 Aug 31

This paper reports the clinical treatment of 100 patients with minimal brain dysfunction (MBD), their age ranged from 7-14.2 years, and the average age was 10.5. Patients were divided into TCM and WM group randomly. The TCM group (80 cases) were treated with the therapy of subdueing hyperactivity of the Liver and invigorating the function of the Spleen by using: Bupleurum chinense, Scutellaria baicalensis, Astragalus membranaceus, Codonopsis pilosula, Ligustrum lucidum, Lophatherum gracile and thread of ivory. The WM group (20 cases) were treated with retalin 5-15 mg twice daily. One course of treatment lasted one month, and effects were evaluated after 1-3 courses of treatment. The results were as follows: In the TCM group, 23 cases were cured (clinical symptom and sign disappeared, 10 IQ units were raised in their intelligence, abnormal electroencephalogram was recovered and there was no recurrence during the first six months after recovery). 46 cases were improved (clinical symptom and sign markedly improved, 4 IQ units raised in intelligence and electroencephalogram improved), and 11 cases ineffective. The effective rate was 86.25%. In the WM group, 6 cases were cured, 12 cases improved and 2 cases ineffective, the clinical effective rate being 90.0%. There was no significant difference between the two groups in this study, but, the side-effects of the TCM group was less than the WM group, and the TCM group had more beneficial effects to improve intelligence, enuresis and the black of orbits. The study showed that the Verbal Scale in Wechsler Intelligence Scale for children is one of the indications of diagnosis and evaluating of the curative effect of MBD.
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PMID:[Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases]. 239 43

By means of TCM differentiation of symptom-complexes, the authors tested and analysed the urine osmotic pressure (UOP) and the urine and plasma osmotic ratio (UPOR) for 428 cases of renal disease, with the conclusion that the UOP and the UPOR were within the normal value range for not only the 36 cases lack of clinical symptoms so as to be unable to have TCM classification identified, but also for 24 cases of Wind edema excess syndrome mainly caused by pathogenic Wind's invasion to the Lung. But for 74 cases of damp-heat Kidney impairment and 294 cases with the main symptom being Kidney deficiency [including weakness of Qi of Kidney, Yang deficiency of Spleen and Kidney, Yin deficiency of Liver and Kidney], the value of their UOP and the UPOR had the tendency of reduction (P less than 0.01), among which the value of the patients of Kidney Yang deficiency reduced most obviously. The further observation showed that, for the nocturia patients caused by renal disease, the value of UOP and the UPOR reduced more obviously than usual. Therefore the authors assert that the test on UOP and UPOR will offer an objective index to patients' nocturia and Kidney-Qi weakness. 60 cases with renal disease of Kidney deficiency syndrome and 27 cases of damp-heat Kidney impairment syndrome under the diagnosis and treatment based on an overall analysis of symptoms and signs leads to the following conclusion: With the elimination of pathogenic factors and recovery of kidney, the damp-heat Kidney impairment patients' UOP will be increased. The low UOP of patients caused simply by Kidney deficiency, however, will recover slower.
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PMID:[Urine osmotic pressure and deficiency-excess syndrome of renal disease: analysis of 428 cases]. 239 45

This paper reports the determined results of rosette rates of red cell C3b receptor and active rosette (Ea) rates of T lymphocyte in 39 cases of nephrotic syndrome. Typology of nephrotic syndrome according to TCM differentiation symptoms, all the 39 cases were divided into three types: (1) 13 cases of deficiency of Qi of the Spleen with stagnancy of dampness; (2) 9 cases of deficiency of Yang of the Spleen and Kidney; (3) 17 cases of deficiency of Yin of the Liver and Kidney. The results showed that the red cell C3b receptor rosette rate and Ea rosette rate in 39 cases of nephrotic syndrome were significantly lower than those in the control. The difference between the two groups was very obvious (P less than 0.001) among the three types. The rosette rates of both in the deficiency of Qi of the Spleen and deficiency of Yang of the Spleen and Kidney were markedly decreased than those in the control (P less than 0.001). Whereas, the red cell C3b receptor rosette rate was lower than that in the control (P less than 0.01), and T cell Ea rosette rate showed no statistical difference (P greater than 0.05) in the deficiency of Yin of the Liver and Kidney. There was a close relationship between the immune dysfunction of red cell and the pathogenesis in nephrotic syndrome. There was markedly relationship between the pathogenesis of deficiency of Yang of the Spleen and Kidney and deficiency of Qi of Spleen with stagnancy of dampness and T cell immune dysfunction. While the Ea level in deficiency of Yin of the Liver and Kidney was closely correlated with the control. Probably this type was nephrotic nephrosis which had been treated with TCM-WM.
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PMID:[Study of the relation of the typology of nephrotic syndrome and red cell C3b receptor, T cell function]. 252 89

102 cases of gastric carcinoma which have been removed by partial gastrectomy and have pathological diagnoses and follow-up results are reported. The relationship between their preoperational syndromes of TCM and pathological, TNM classification and post-operational survival rate has been studied. There is indication that the type of Ganwei Buhe (the dispersing function of the liver is disturbed and affects the stomach) manifests the earlier stage of the gastric carcinoma and the majority of cases are in stage 1 or 2 in TNM, the 5-year survival rate with surgery being 46%. The majority of cases of the types of Pishen Yangxu (deficiency of energy in the Spleen and Kidney), Yinxu Neire (the febrile syndrome of the viscera caused by the insufficient primordial energy) and Qixue Shuangkui (deficiency of both energy and blood) are in stage 3 or 4 in TNM, the 5-year survival rate with surgery differently being 5,8,12% respectively. The type of Qizhi Xueyu (energy stagnancy and blood stasis) is between the abovementioned two groups, with a 5-year survival rate of 40%.
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PMID:[The relation of typing of gastric carcinoma according to traditional Chinese medicine theories and clinical pathologic classification]. 255 Jan 58

The gastric mucosa trace elements and oxides were investigated with X-ray energy disperse analysis system in 41 cases of gastric disease due to Spleen deficiency. The differences in the change of the quantity of Zn, Cu, ZnO and CuO were very significant (P less than 0.05-0.001) in the gastric mucosa between normal area and focal area, between Spleen Qi deficiency and Spleen deficiency with Qi stagnation, and between benign gastric disease and gastric cancer. The experiments showed that: (1) The trace elements in the organism form its own system, the values being within the relatively constant scope. (2) The ratios of Zn/ZnO and Cu/CuO reflected "the rate of effectual utility" of Zn and Cu. (3) There was a very close internal relation between Spleen deficiency with Qi stagnation and gastric cancer. (4) The quantitative changes of Zn, Cu, ZnO, CuO, Zn/ZnO and Cu/CuO were related to pathologic change and the TCM syndrome pattern, and is worthy of further research.
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PMID:[Clinical significance of the measurement of trace elements in the gastric mucosa and their oxides in patients with spleen diseases and gastric cancer]. 262 86

The patients with lipometabolic disorder were randomly divided into control group (70 cases), Fungus Lipid-reducing Capsule (FLC) treated group (70 cases), augmented treated group (90 cases). The results shown that: (1) TC and TG were reduced markedly in all three groups. The reducing extent in the treated group was greater than that in the control group (P < 0.01). HDL-C was increased markedly in all three group. The increasing extent in the treated group was greater than that in the control group (P < 0.05). These results indicated that the effectiveness of FLC was higher than that of control drug in the treatment of hyperlipidemia. (2) FLC had obvious effect in improving hemorheology indexes. (3) The therapeutic effect of TCM Syndrome-type indicated that FLC could activate the Spleen, remove Dampness and nourish the Liver and Kidney.
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PMID:[Clinical study on fungus lipid-reducing capsule in regulating lipometabolic disorder]. 764 May 1


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