Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0153470 (Spleen)
 4,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The serum of rats obtained at various time intervals after administration of AAF was tested for its action on the 3H-thymidine incorporation into the DNA of thymocytes in vitro. In comparison with untreated or solvent-treated controls, the sera of animals in the early phase after the AAF-treatment stimulate the incorporation of the nucleotide into the thymocytes of rats, mice and hamsters. This reaction shows an unequivocal dose-response relationship. The serum activity is dialysable and relatively thermostable. Spleen lymphocytes and peritoneal cells of rats are insensitve to the AAF-serum. A possible relationship between growth-stimulating serum activities in liver regeneration and in early carcinogen action is discussed.
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PMID:Stimulation of thymocytes in vitro by serum of 2-acetylaminofluorene (AAF)-treated rats. 31 82

Eighteen kinds of serum free amino acid (SFAA) were measured in 32 patients with Spleen-Deficiency (SD) Syndrome. Several obvious changes were noticed as compared with 20 healthy adults: (1) The levels of total FAA, essential amino acids and free branched-chain amino acids of SD group were significantly lower than that of the control group (P < 0.01); (2) Total FAA, essential amino acids and branched-chain amino acids were all positively correlated to D-xylose absorptivity, serum protein and immune function. The above results suggested that the decrease of various SFAA level might be related to malabsorption in patients with SD. It is possible that the decrease of serum protein and immune function was due to the lowering of SFAA.
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PMID:[Changes in serum free amino acid level in patients with spleen deficiency syndrome]. 795 Feb 24