Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0153470 (Spleen)
 4,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Our understanding of the mechanisms involved in B cell activation, proliferation and differentiation to immunoglobulin secreting cells has been facilitated by the use of T-independent and T-dependent antigens. The majority of these studies have used the murine system and only recently, the rat. Because membranes isolated from Mycoplasma neurolyticum are potent B cell mitogens in the rat and some T-independent antigens also activate DNA synthesis in B cells, the in vitro and in vivo antibody responses induced by M. neurolyticum membranes in T-deficient rat systems were examined. The three groups of rats used, i.e., nude; anti-thymocyte serum-treated, neonatally-thymectomized (ATS-Tx); and normal Fischer 344 produced a non-polyclonal antibody response against the membranes. Spleen cell cultures that were T cell deficient and B cell enriched produced plaque-forming cells against the Mycoplasma membranes. Antibody production was depleted upon removal of Sephadex G-10 adherent cells. The antibody response is comprised of both antigen-specific and polyclonal responses. Lipoglycan, found in the aqueous phenol extract of the membranes, is the mitogenic fraction of the membranes, and this study suggests that it may also be the T-independent antigenic component of the M. neurolyticum membranes.
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PMID:Mycoplasma neurolyticum membranes: a T-independent antigen in the rat. 242 52

Thymus, spleen, and lymph node cells from different periods of Sarcoma I allograft development in untreated (Sa I) or xenogeneic antithymocyte serum-treated (ATS-Sa I) B10 mice were adoptively transferred to secondary B10 recipients. While in sublethally (4.3 Gy) irradiated recipient mice the tumor destructing activity was predominantly expressed, in untreated recipients of transferred cells it was mostly the tumor enhancing activity. Therefore, in further studies directed at the detection of tumor enhancing activity, the adoptive transfers were only performed in untreated recipients. Thymus cells both of Sa I and ATS-Sa I mice showed a tumor enhancing activity all through the followed period, with a peak between days 7 and 21, then it decreased. Also the spleen cells of both groups had a tumor enhancing effect all the time, with a peak of activity on day 7. Spleen and thymus cells of progressors enhanced the tumor growth slightly more strongly than did those of the regressors. The tumor enhancing activity of spleen cells was in the beginning period confined mainly to the polystyrene nonadherent fraction of cells, at later times, in the progressors it was manifested in the adherent as well as in the nonadherent fractions. In the population of lymph node cells, at the start of tumor regression (in Sa I mice on day 7, in ATS-Sa I mice on day 14), a tumor destructing activity was observed. In both groups this activity was at later times followed by a tumor enhancing activity. The interpretation of the tumor enhancing activity of thymus and spleen cells of Sa I and ATS-Sa I mice is complicated by the tumor enhancing activity of cells of normal mice without tumor (N).
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PMID:Immune response of mice to sarcoma I allograft studied by adoptive transfers of spleen, thymus, and lymph node cells to secondary recipients. 404 56