Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0153470 (
Spleen
)
4,015
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The discovery of novel 5,7-disubstituted[1,6]naphthyridines as potent inhibitors of
Spleen
Tyrosine Kinase (SYK) is discussed. The
SAR
reveals the necessity for a 7-aryl group with preference towards para substitution and that this in combination with 5-aminoalkylamino substituents further improved the potency of the compounds. The initial
SAR
as well as a survey of the other positions is discussed in detail.
...
PMID:Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK). 1266 2
