Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0153470 (
Spleen
)
4,015
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-21
(
IL-21
) is a novel cytokine that can induce proliferation of activated T cells and maturation of natural killer (NK) cells. We therefore examined whether expression of the
IL-21
gene in tumor cells could generate antitumor responses. Murine colon carcinoma Colon 26 cells that were transduced with the mouse
IL-21
gene (Colon 26/
IL-21
) were rejected in syngeneic mice and the mice subsequently acquired protective immunity. The growth of Colon 26/
IL-21
tumors developed in nude mice was retarded compared with that of parent tumors, and this growth suppression was not observed in nude mice that were treated with anti-asialo GM(1) antibody.
Spleen
cells from the mice that had rejected Colon 26/
IL-21
cells showed cytotoxic activity to Colon 26 but not to irrelevant tumor cells, and produced larger amounts of interferon-gamma upon stimulation with irradiated Colon 26 cells.
Spleen
cells from Colon 26/
IL-21
-tumor- but not parent-tumor-bearing mice had lytic activity to YAC-1 cells. These data suggest that expression of
IL-21
in tumors induces T- and NK-cell-dependent antitumor effects.
...
PMID:Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. 1263 39
