Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153429 (Meckel's diverticulum)
 1,196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 22-year-old man with burning pain in the lower abdomen and rectal bleeding had a sodium pertechnetate Tc 99m scan. The scan showed an area of uptake in the right lower quadrant which at operation was found to be a Meckel's diverticulum. The ability of ectopic gastric mucosa within a Meckel's diverticulum to concentrate sodium pertechnetate Tc 99 m allows for this noninvasive diagnosis of some types of rectal bleeding, especially when the cause has escaped detection by conventional endoscopic and barium contrast examinations.
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PMID:Preoperative diagnosis of rectal bleeding in an adult using a radioisotope scan. 30 63

Twenty pediatric patients presenting primarily with unexplained gastrointestinal bleeding were evaluated with sodium pertechnetate Tc 99m imaging. Three patients had normal barium enemas and scans consistent with Meckel's diverticulum. These three patients and three additional patients with normal scans underwent surgical exploration. Meckel's diverticula containing gastric mucosa were found in all three patients with positive scans. No diverticula were found in the three patients with normal scans. Four other patients had scans that were considered abnormal but not felt to represent Meckel's diverticula. In one of these patients a radiographic gastrointestinent, a nonspecific terminal ilial ulcer without gastric mucosa was found at surgery. The two other patients had normal radiographic gastrointestinal studies and no further evaluation was carried out. The etiology of gastrointestinal bleeding in pediatric patients is frequently unexplained even after thorough evaluation including celiotomy. The sodium pertechnetate Tc 99m scan is a safe, simple, non-invasive procedure that can demonstrate Meckel's diverticula with greater certainty than the barium enema and can suggest suspicious areas that can then be evaluated by more definitive procedures.
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PMID:The sodium pertechnetate Tc 99m scan: an aid in the evaluation of gastrointestinal bleeding. 108 May 57

The clinical illness observed in a 5-month-old infant with Meckel's diverticulum is described. A sodium pertechnetate radioisotope scan was employed to confirm the clinical impression. The technical procedure, evaluation, and importance of the radioisotope study is discussed.
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PMID:Diagnosis of Meckel's diverticulum by radioisotope scanning. 124 86

Three patterns of intestinal activity were noted in a review of 64 patients studied with Tc-99m sodium pertechnetate for suspected Meckel's diverticulum: no bowel activity seen (37.5%), bowel activity visualized after stomach activity (39.1%), and diffuse bowel activity seen simultaneously with stomach activity (23.4%). The latter pattern, which is relatively common, could mask a true Meckel's diverticulum and lead to either a false-negative or indeterminate diagnosis. A series of 10 dogs was also studied to evaluate the effects of fasting and feeding on the intestinal pattern. No definite relationship was observed.
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PMID:Patterns of intestinal activity with Meckel's scintigraphy. 609 98

The demonstration of secretory gastric mucosa in Meckel's diverticulum of the ileum in patients undergoing radionuclide imaging with 99mTc sodium pertechnetate is greatly improved with the prior administration of cimetidine. This results in enhanced accumulation of pertechnetate in the gastric mucosa along with reduced excretion of the radionuclide into the gastric lumen and, consequently, less intestinal radioactivity.
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PMID:Pertechnetate imaging following cimetidine administration in Meckel's diverticulum of the ileum. 627 24

Parietal cells, which exist in the stomach and in Meckel's diverticulum of the ileum, secrete hydrochloric acid by means of H+,K(+)-ATPase (alpha- and beta-subunits) in the human body. Although parietal cells are generated from progenitor cells (stem cells), their lifespan (approximately 150-200 days) is distinctly longer than that of surface epithelial cells (4 days), which are also derived from stem cells. Microorganisms, including bacteria (both aerobic and anaerobic), are able to pump H+ out by means of H(+)-ATPase. Of interest is that 19% of the human H+,K(+)-ATPase (alpha-subunit) comprises amino acid residues identical to those of the H(+)-ATPase found in Neurospora crassa. In addition, the amino acid sequence in the ATP binding sites of animal Na+,K(+)-ATPase and yeast H(+)-ATPase with phosphorylated intermediates is highly conserved. These data appear to indicate that the parietal cell might have originated from a microorganism that was parabiosed in a separate origin, having digestive organs, that was later incorporated into a stem cell. Thereafter, the gene encoding H+,K(+)-ATPase, or those encoding GATA DNA binding proteins (transcriptional regulators of the gastric H+,K(+)-ATPase gene), or both were translocated into the nuclei, most probably with the aid of a virus and/or a transposon under unusual circumstances. This type of gene translocation most probably occurred during the Cambrian era when Prochordata and Chordata, which have no parietal cells, were abundant. This suggests that in the process of evolution, the stem cells in the digestive organs of the Cordata might have differentiated into two cell types, i.e., surface epithelial cells and parietal cells, before the appearance of fish (which possess parietal cells with H+,K(+)-ATPase).
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PMID:Hypothesis--origin of the parietal cell: microorganism? 947 41