Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0152447 (urethral discharge)
 296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven male Macaca nemestrina, eight male Macaca mulatta and three male Papio hamadrias were infected with M. hominis or U. urealyticum separately or simultaneously into the urethra. Animals of the first two species exhibited moderate infection and mild clinical urethritis characterized by increased number of PMNL in the urethral discharge and colonization and lymphocytic infiltration of the mucous membrane of the urethra and urinary bladder. Animals of the third species proved to be less sensitive.
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PMID:Urethral infection of male monkeys by Mycoplasma hominis and Ureaplasma urealyticum. 236 22

A case of localized amyloidosis of the urethra is reported. A 42-year-old man visited with the complaint of urethral discharge and urethral tumor on May 24, 1985. A small fingertip sized, elastic hard mass was present on the left side of the external urethral meatus. Cold cup biopsy of the urethral tumor was done. Histological examination of the tumor showed amorphous eosinophilic tissue staining. Green birefringence indicating amyloidosis by Congo red staining was observed under polarized light microscope. Since the patient's symptoms were minimal, no specific therapy was instituted.
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PMID:[A case of localized amyloidosis of the urethra]. 243 77

We have reported a gonococcal infection in a surgical incision made ten months before the onset of urethral discharge. Gonococcal wound infections may arise from direct contamination or possibly by blood-borne dissemination. Principles guiding therapy are similar to those for wound infections from other organisms, with attention to adequate drainage, removal of foreign body, appropriate antibiotics, and elimination of contributing sources of infection.
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PMID:Gonococcal wound infection. 250 91

The etiology of urethritis was determined for 303 Thai men with urethral discharge containing 5 or more polymorphonuclear cells (PMN)/high power field (hpf) and 132 men with a discharge containing less than 5 PMN/hpf. Neisseria gonorrhoeae was isolated significantly more often from men with greater than or equal to 5 PMN/hpf than from men with less than 5 PMN/hpf (42% vs 1%, P less than .0001). Chlamydia trachomatis was also isolated more often from patients with greater than or equal to 5 PMN/hpf than from men with less than 5 PMN/hpf (16% vs 8%, P less than .03). Ureaplasma urealyticum was isolated with nearly equal frequency from both groups of patients (45% vs 37%). Among men with a urethral exudate containing greater than or equal to 5 PMN/hpf, N. gonorrhoeae was isolated as the only pathogen from 19% and in combination with C. trachomatis or U. urealyticum in 23% of these men. C. trachomatis or U. urealyticum, but not N. gonorrhoeae, was isolated from 30%, and no pathogen was isolated from 28% of these men. Among men with urethral exudate containing less than 5 PMN/hpf, N. gonorrhoeae was isolated from only 1%, C. trachomatis or U. urealyticum from 41%, and no pathogen from 58%. These findings suggest that all Thai men with urethral discharge containing greater than or equal to 5 PMN/hpf should be treated for non-gonococcal urethritis and for gonococcal urethritis if gram-negative diplococci are demonstrated on gram stain of the urethral discharge. Men with urethritis with less than 5 PMN/hpf should be treated for only non-gonococcal urethritis.
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PMID:Etiology of urethritis in Thai men. 251 Mar 27

Participants in the study were drivers and turnboys who passed through a transport depot in Kampala, Uganda, in November 1986. Each participant answered a questionnaire aimed at determining basic demographic data, countries visited within the previous 3 years, level of prostitute contact within those countries, and whether they had had a history of urethral discharge or genital ulceration. A total of 45 drivers and 23 turnboys with a mean age of 38 and 26 years, respectively, were interviewed and blood samples were taken. Serological controls were selected from people of the same age as the study group from individuals donating blood. Serum immunoglobulin (Ig) antibodies to HIV were determined by a competitive enzyme-linked immunosorbent assay and a competitive ELISA using recombinant HIV core and envelope proteins. All serological results were verified by immunoblot assays or were prepared by electrophoretic separation of U937 cell lysates infected with a Ugandan HIV-1 isolate. Antibodies to Treponema pallidum were detected by a hemagglutination test. They were of Ugandan (66.2%) or Kenyan (33.8% ) origin. All were sexually active, and all denied homosexuality and intravenous drug use. The overall HIV-1 seropositivity rate was 35.2%, compared with the control group of 9.2% (24 out of 68 versus 12 out of 130; p 0.01). Using the antigen detection systems, 7 of the seronegative sera proved to be antigen positive. In addition, 4 out of the 24 seropositive sera (16.6%) also proved to be antigen positive. 36.7% of the population admitted more than 50 lifetime sexual partners. Of the remainder, 83.7% had had more than 10 lifetime sexual partners. The level of urethral discharge and genital ulceration revealed a significant difference (p 0.01) between seropositive and seronegative individuals. The overall level (55.8%) of T. pallidum antibodies among drivers and turnboys was significantly higher than in the control group (p 0.01). The drivers had the highest level of T. pallidum antibodies (62.2%) compared with turnboys (43.8%), reflecting the older average age and, thus, the greater sexual experience.
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PMID:Prevalence of HIV-1 in east African lorry drivers. 251 82

Gonodecten (Gd; U.S. Packaging Corp., LaPorte, Ind.) is a commercially available test for the presumptive diagnosis of gonococcal urethritis in men. With this test, urethral discharge is collected on a swab, placed in a plastic tube, and moistened with oxidase reagent. Development of a purple color on the swab within 3 min indicates the presence of gonococci. This system was compared with culture and Gram-stained smear for the diagnosis of gonorrhea. Of 240 specimens tested, 174 were positive with culture, Gram stain, and the Gd test and 48 were negative with all tests. For eight specimens, cultures and smears were positive, but the Gd test was negative. Nine specimens produced positive Gd tests with negative smears and cultures. Only one specimen was positive on culture and with the Gd test and negative on Gram-stained smear. Haemophilus species were isolated from 14 specimens; 5 produced positive Gd test reactions, with gonococci being coisolated from 4. The sensitivity and specificity of the Gd test compared with culture were 95.6 and 84.2%, respectively, whereas the Gram stain was 99.5% sensitive and 100% specific compared with culture. The Gd test may be a useful screening test for the diagnosis of gonorrhea in men with urethral discharge, particularly in settings where a microscope, Gram stain reagents, or technological expertise is not readily available.
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PMID:Evaluation of Gonodecten for the presumptive diagnosis of gonococcal urethritis in men. 257 91

We studied the prevalence of Chlamydia trachomatis (CT) infection as well as its predictors among a sample (1000) of visitors (651 male, 349 female) of a clinic for sexually transmitted diseases (STD) in Amsterdam. The prevalence of CT was higher than that of gonorrhoea: among men, 14.3% and 11.5% and among women, 12.9% and 6.3% respectively. Independent predictors for CT infections were for men: number of leucocytes in discharge or urine, nature of urethral discharge, age and sex behavior, and in women: being warned as source or contact of a STD, age, nature of cervical discharge and bleeding from the cervical ostium after insertion of a swab. As many as 92% of the male and 81% of the female visitors of our STD clinic should be examined for CT if the presence of anyone or more of these predictors is taken as a criterion. Even then, 5% of the CT infections in women would still be missed. Based on our study results, material for the diagnosis of CT will from now on be collected routinely from all female patients of our STD clinic as well as from all males with urethritis. We advocate the expansion in the Netherlands of facilities for laboratory CT detection and its standard inclusion in STD examination.
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PMID:[Prevalence and risk factors of Chlamydia trachomatis infection in clients of a venereal disease clinic in Amsterdam]. 258 77

A 20 year old man affected by a persistent peno-scrotal lymphedema is reported. This condition followed recurrent attacks of cellulitis and a chronic urethritis. From the urethral discharge we isolated Chlamydia trachomatis and, only during the attacks of cellulitis, Group G Streptococcus. This pathogen cannot be isolated from microflora of the normal urethra and rarely cause cellulitis. In our opinion Chlamydial infection favoured the urethral colonization of Group G Streptococci and their passage in the loose connective tissue of the penis and scrotum. Lymphedema, clinically inapparent before the first attack, become progressively more severe and recurrent attacks took place at intervals without obvious re-exposure to an exogenous source of streptococci. The operative treatment of persistent lymphedema is lymphangiectomy and lymphangioplasty.
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PMID:[Persistent lymphedema of the penis and scrotum after recurrent episodes of cellulitis and urethritis caused by Chlamydia trachomatis]. 263 Apr 39

A case of male urethral melanoma is reported. A 85-year-old male with a 2-month history of progressive, severe obstructive urinary symptoms and bloody urethral discharge was referred to us after an unsuccessful management at a local doctor. Physical examination revealed an ill looking old man with no evidence of nevi or other cutaneous pigmentation looking like malignant melanoma. Neither palpable periurethral mass nor inguinal lymphadenopathy was noted. RUG showed an irregular shadow defect in bulbous urethral regions. In cystourethroscopy, a raised nodular reddish black lesion in the urethra without adjacent satellite lesions was found. Histologic examination revealed that the tumor was made up of closely spaced, anaplastic, spheroidal or polyhedal cells. Intracellular brown pigment was richly present, gave a negative reaction for iron, but stained black with Masson-Fontana's method. Further examination for evaluating metastases including bone scintigraphy, computer tomographic scan, chest X-ray film were negative. Due to his poor risk, radical operation such as cystourethrectomy might be undesirable. We performed TUR to relieve urethral obstruction, because the patient refused cystostomy. He died of wide spread metastases at 6 months after the operation. This case seems to be the second report in the Japanese literature.
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PMID:[Malignant melanoma of male urethra: a case report]. 265 6

The pediatric acute scrotum can be a diagnostic dilemma. The history, physical examination, and appropriate tests are important. The correct diagnosis will be arrived at if the systematic approach is remembered (Figure 14). In cases where testicular torsion cannot be ruled out (such as an epididymitis or torsion of the appendix testis where torsion of the testis is mimicked), the patient will need scrotal exploration. It is hoped that with further availability of scanning and expertise by pediatric surgeons the false negative exploration will decrease in number. Remember, occasionally a patient will require scrotal exploration with biopsy of the epididymis to delineate the underlying cause. In most cases of epididymitis, effort should be made to identify the cause by culture of urine, urethral discharge, or appropriate fluid from the epididymis. Urological evaluation will be necessary in the younger boys, particularly those with recurrent episodes, to rule out congenital anomalies. Only by following this systematic approach can clinicians hope to preserve gonadal function and achieve best care of their patients.
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PMID:The pediatric acute scrotum. 266 80


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