Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0152447 (urethral discharge)
 296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a trial of 2 grams oral single dose of amoxycillin on 70 patients with acute gonococcal urethritis, 64 patients had full bacteriological cure, 4 patients were lost to follow up and presumed cured, two patients, still had gonococcal urethritis one week after treatment but one admitted to re-exposure and subsequently recovered with a second 2 gram single dose of "amoxil". Among 30 patients with non gonococcal Urethritis (N.G.U.) treated similarly, a fairly good response was obtained in those patients in whom Staph. Aureas was absent from the urethral discharge. However single dose therapy was considered unsuitable for non gonococcal urethritis.
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PMID:Two gram single dose amoxycillin in treatment of gonococcal and other urethritides. 81 29

Acute purulent urethritis is a complication associated with an indwelling. Foley catheter in male patients. A refractory purulent urethral discharge, fever and the sequelae of urethral stricture, periurethral abscess and epididymitis are familiar problems to the urologist. The usual therapy is removal of the catheter, antibiosis and provision for another type of vesical drainage. Our recent successful experience using clean intermittent catheterization to treat an acute urethritis is presented.
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PMID:Intermittent catheterization in the treatment of acute purulent urethritis: case report. 83 83

Chlamydia trachomatis was isolated from 26% of urethral swabs taken from 509 men with urethritis. The highest yield of 68% was obtained from a selected group of men with nonspecific urethritis (NSU) who had a frank urethral discharge. This is a higher than in previous reports, and is significantly higher than the isolation of C. trachomatis from men with less severe urethritis. The higher yield was similar to C. trachomatis isolation rates reported among patients with severe trachoma in hyperendemic areas. Men with a previous history of NSU had low isolation rates. Overall, 30% of 385 men with NSU had positive chlamydial culture results, 7% of 59 men with gonococcal urethritis alone were Chlamydia-positive, 15% of 59 men with gonorrhoea followed by NSU (post-gonococcal urethritis) were Chlamydia-positive, and only 3% of 61 men without urethritis harboured Chlamydia. Swabs taken from the cervical os of 28 of 108 female contacts of men with NSU had a positive result for C. trachomatis. Significantly more pairs of sexual partners had the same chlamydial culture result than had different results. The chlamydial isolation rate was higher among men admitting a casual sexual contact than in men claiming only regular partnerships. The findings provide further evidence for the sexual transmission of C. trachomatis and for its aetiological role in NSU.
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PMID:Isolation of Chlamydia trachomatis from the male urethra. 87 Jan 45

Single-dose antibiotic therapy was evaluated in 108 episodes of culture-confirmed, uncomplicated gonorrhea in 100 prepubertal children. There were 15 boys and 85 girls between 14 months and 14 years of age. Penicillin G procaine, 100,000 units/kg intramuscularly, was compared with amoxicillin trihydrate, 50 mg/kg orally. Probenecid, 25 mg/kg, was given simultaneously. Both drugs provided prompt bacteriological and clinical response. Multiple episodes of gonorrhea, presumably caused by reexposure, occurred in six girls. Oral and anal cultures were negative in all of 47 Costa Rican cases but were commonly positive in US children. Anal cultures yielded gonococci in 52% of girls and 25% of boys, and oral cultures were positive in 18% and 13%, respectively. In three instances, rectal cultures confirmed the diagnosis when vaginal cultures were negative. Gonorrhea should be considered in every child with vaginal or urethral discharge. Single-dose penicillin-probenecid or amoxicillin-probenecid treatment is curative.
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PMID:Gonorrhea in preschool- and school-aged children. Report of the prepubertal gonorrhea cooperative study group. 98 90

A patient with nonspecific urethritis (NSU) and his consort were examined for infection with NSU corynebacteria, mycoplasmas, and gonococci. No classic and T-mycoplasmas or gonococci were cultured, but one species of NSU corynebacteria was isolated not only from the patient's urethral discharge during three episodes of NSU but also from his consort. It was not isolated after successful treatment of the patient with tetracycline and the use of condoms prevented reoccurrence of urethritis. This NSU corynebacterium was isolated previously from one epididymitis patient and two NSU patients but not from any of the normal male and female subjects examined. Therefore, this strain is considered to be one of the etiologic agents of NSU and female subjects are asymptomatic carriers. In consequence, it is suggested that NSU corynebacteria which are commensals and pathogens of the male and female urogenital tracts should be incorporated in a new species, of the Coryneform group, and that this strain should be the type species, Corynebacterium genitalium n. sp.
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PMID:Infection of a nonspecific urethritis patient and his consort with a pathogenic species of nonspecific urethritis Corynebacteria, Corynebacterium genitalium, N. SP. 103 91

A survey was conducted in Swaziland between July 6 and September 28, 1973 to obtain information about sexually transmitted diseases. The survey sample was limited to the outpatient department of the government hospital at Mbabane. Patients included were those who reported at the outpatient department with an STD during the 3 month period of the survey and those of their contacts who could be pursuaded to attend and were found to be infected. Of 240 patients seen during the course of the survey, 124 were suffering from presumed gonorrhea, 67 had genital sores, and 23 reported with both. A further 26 had positive Venereal Disease Research Laboratory (VDRL) reactions and were assumed to have syphilis with or without some other STD. Of the 26 patients whose VDRL test was positive, 3 had lesions usually associated with primary syphlis and 3 had condylomate lata. The rest were cases of presumed latent syphilis presenting with another infection. With 1 exception cases of urethral discharge in men appeared to be due to gonorrhea. No cases of nonspecific urethritis were seen and the explanation of this is obscure. About 29% of the women and 4% of the men were infested with T. vaginalis. It was not possible to determine the prevalence of venereal diseases, but the evidence collected supported the local impression that these conditions were increasing. The need for a vigorous program of contact tracing is clear from the small proportion of female patients attending the clinic. Only 24% of those with a sexually transmitted disease and only 20% of those with a positive VDRL test were females, whereas in a survey undertaken by staff of the local public health unit in 1967, 54% of those with a positive Wassermann reaction were female. The large number of casual partners admitted by men in the 4 weeks before infection implies that this is a major source of infection. Recommendatons made for improving the situation include: offering education in the schools; developing a universal system for tracing contact for the whole country; and making a vigorous attempt to screen all pregnant women by means of the VDRL test.
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PMID:Some aspects of sexually transmitted disease in Swaziland. 103 69

Maternal, fetal, and neonatal morbidity and mortality can be significantly decreased by selective screening of prenatal patients for gonorrhea, early treatment, and follow-up cultures after treatment for gonorrhea. Ophthalmia is the most significant neonatal gonococcal infection. Administration of silver nitrate at delivery is the best prophylaxis against gonococcal ophthalmia. Treatment of gonococcal ophthalmia, however, requires parenteral penicillin, conjunctival antimicrobial therapy, and hospitalization. Treatment of the gonococci-infected mother is also indicated. Childhood gonorrhea is most commonly manifested as vulvovaginitis in girls or urethritis in boys, usually without associated disseminated gonococcal infection. Transmission can occur by indirect contact with an infected parent or involuntary or voluntary sexual activity: in children over age 10 years transmission of gonococci most commonly involves voluntary sexual activity. Emphasis should be placed on early treatment of the infected child, follow-up cultures, and contact tracing. Diagnosis of gonococcal infection requires adequate specimens, gram stains, and cultures for N. gonorrhoeae. In disseminated neonatal gonococcal disease, gram strains and cultures of the conjunctiva, oropharynx, orogastric aspirates, anogenital area, umbilicus, and external ear canal frequently aid in the diagnosis. Frequently, a gram strain of the urethral discharge in boys is sufficient for diagnosis of gonorrhea; in girls cultures are necessary. Since the incidence of gonorrhea in children has increased, the importance of epidemiologic analysis and follow-up after treatment can not be overemphasized.
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PMID:Neonatal and childhood gonococcal infections. 109 81

Trichomonas vaginalis is a flagellate protozoon which in women commonly causes vaginal itching; burning, and a frothy, offensive and seropurulent yellowish discharge. Incidence of infection in women varies from 13 to 60%, and is highest during pregnancy because of excess estrogens and in women with poor hygiene or with vaginitis. In men, the incidence ranges from 9 to 37% of persons with urethral discharge. This study presents the results of the use of a single dose treatment of Trichomonas vaginitis with 2.0 gm Tinidazole. 350 women with vaginal discharge from the Gynecology Dept. of Cairo University hospitals were studied. Microscopic study of the discharge revealed T. vaginalis in 103 cases (aged 17 to 48 years). Majority of the clinical complaints (pruritus vulvae; soreness; sense of fullness in vagina and dysuria) disappeared in all cases after administration of 2.0 gm single dose of Tinidazole. Discharge; dyspareunia and soreness or pain at vulval interoitus disappeared in about 2/3 of cases; improved in about 1/4 and persisted in less than 8% (failure in these cases was attributed to other causes such as cervical erosion; bacterial infections; hormonal or other pathologic lesions in the internal genitalia). Mild gastrointestinal reaction (nausea and vomiting) were observed in 5 cases and transient urticaria in 1 case.
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PMID:Treatment of Trichomonas vaginitis with a single dose of tinidazole. 123 91

The study was designed to assess the value of information from male subjects under fertility investigation, regarding previous genital infection, in clarifying the causes of depressed sperm quality. Information was gathered using a questionnaire which was sent to 312 men who had previously attended our laboratory for semen analysis. A previous sexual transmitted disease (STD) in the male partner did not significantly influence the sperm quality or the pregnancy rate. However, a previous STD in the female was generally associated with a lower pregnancy rate. Previous episodes with urethral discharge, dysuria, pain with ejaculation or suprapubic discomfort had little relevance for the subsequent sperm quality. The results indicate that, in general, information provided by men under fertility investigation, regarding previous genital infections or symptoms, is only of limited value in elucidating the cause of impaired sperm quality.
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PMID:The value of anamnestic information regarding previous genital infection in male fertility investigation. 129 7

Epstein-Barr Virus (EBV) can infect B lymphocytes as well as epithelial cells of the oral cavity. Recently, infection of epithelial cells of the inflamed uterine cervix has been demonstrated, and EBV-DNA has been detected in urethral discharge of men suffering from genital infection. We investigated whether EBV can be found in the genital tract of both sexes independently from inflammatory disease states. Genital specimens of men and women of a sexually transmitted diseases outpatient clinic after excluding sexually transmitted diseases and clinically apparent signs of inflammation were investigated using the polymerase chain reaction to screen for EBV-DNA. In 13 of 47 samples (27.7%) swabbed from the uterine cervix, EBV-DNA could be detected. Similarly, 6 of 45 samples (13.3%) scraped from the sulcus coronarius contained EBV-DNA. Our study shows that the female genital tract and likewise the male genital tract can subclinically harbor EBV. These findings suggest i) that in addition to the oral cavity, the female and the male genital tract may be a reservoir for EBV and ii) that sexual transmission of this virus associated with an epidemiology different from that of oral infection may be possible.
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PMID:Subclinical Epstein-Barr virus infection of both the male and female genital tract--indication for sexual transmission. 131 67


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