Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0152447 (urethral discharge)
 296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study population comprised 276 patients who were either referred to a sexually transmitted diseases clinic or invited to attend through contact-tracing between October 1976 and December 1977. 156 (57%) were men and 120 (43%) women. 43% (119) of the patients were aged between 16 and 29 years. Urethral specimens were collected from all men who presented with urethral discharge using a sterile cotton-wool swab passed into the anterior urethra; the swab was plated directly on to plates of Thayer-Martin (Oxoid) and chocolate agar medium. In women, specimens were obtained with a swab from the cervical os and vaginal vault under direct vision with a Cusco's speculum and processed as above. A wet preparation of the genital discharge was examined for Trichomonas vaginalis, Candida albicans, and parasites, and specimens showing yeast cells were plated on Sabouraud's agar; C albicans was identified by the germ-tube test. Serum from each patient was tested by the Venereal Disease Research Laboratory test and Reiter protein complement fixation test. The most common diagnosis was non-specific genital infection, in 164 (59.4%) of the 276 patients. Gonorrhea was diagnosed in 53 (19.2%) patients and candidosis and trichomoniasis each in 29 (10.5%). Antitreponemal antibodies were detected in 1.4% of patients; all were cases of latent syphilis. Venereophobia, lymphogranuloma venereum, genital warts, and a miscellaneous group of conditions accounted for the remainder of cases. More than one diagnosis was confirmed in 6.5% of patients. Analysis of the source of infection showed that 34.1% of all patients contracted infection through casual partners whom the patients had met only once and could not name or trace; regular partners and prostitutes were the source of infection in 11.6% and 19.2%, respectively. Four strains of N gonorrhea had a minimum inhibitory concentration (MIC) of 0.075-0.3 mcg/ml and two strains an MIC of or= 0.6 mcg/ml. None of the six strains that were relatively resistant to penicillin produced beta-lactamase.
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PMID:Sexually transmitted diseases in clinic patients in Lagos. 689 89