Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0152447 (urethral discharge)
 296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study population comprised 276 patients who were either referred to a sexually transmitted diseases clinic or invited to attend through contact-tracing between October 1976 and December 1977. 156 (57%) were men and 120 (43%) women. 43% (119) of the patients were aged between 16 and 29 years. Urethral specimens were collected from all men who presented with urethral discharge using a sterile cotton-wool swab passed into the anterior urethra; the swab was plated directly on to plates of Thayer-Martin (Oxoid) and chocolate agar medium. In women, specimens were obtained with a swab from the cervical os and vaginal vault under direct vision with a Cusco's speculum and processed as above. A wet preparation of the genital discharge was examined for Trichomonas vaginalis, Candida albicans, and parasites, and specimens showing yeast cells were plated on Sabouraud's agar; C albicans was identified by the germ-tube test. Serum from each patient was tested by the Venereal Disease Research Laboratory test and Reiter protein complement fixation test. The most common diagnosis was non-specific genital infection, in 164 (59.4%) of the 276 patients. Gonorrhea was diagnosed in 53 (19.2%) patients and candidosis and trichomoniasis each in 29 (10.5%). Antitreponemal antibodies were detected in 1.4% of patients; all were cases of latent syphilis. Venereophobia, lymphogranuloma venereum, genital warts, and a miscellaneous group of conditions accounted for the remainder of cases. More than one diagnosis was confirmed in 6.5% of patients. Analysis of the source of infection showed that 34.1% of all patients contracted infection through casual partners whom the patients had met only once and could not name or trace; regular partners and prostitutes were the source of infection in 11.6% and 19.2%, respectively. Four strains of N gonorrhea had a minimum inhibitory concentration (MIC) of 0.075-0.3 mcg/ml and two strains an MIC of or= 0.6 mcg/ml. None of the six strains that were relatively resistant to penicillin produced beta-lactamase.
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PMID:Sexually transmitted diseases in clinic patients in Lagos. 689 89

Malawi is one of the countries that has been most affected by the HIV epidemic with an estimated national HIV seroprevalence rate of 10% in the age group over 15 years and 32% among pregnant women who attended prenatal clinics in Blantyre in 1993. Queen Elizabeth Central Hospital (QECH) is the district hospital in Blantyre, Malawi, and the tertiary referral hospital for Malawi's southern region. About 11,000 patients were admitted there in 1993. The aim of this cross-sectional study was to determine the prevalence of sexually transmitted diseases (STDs) in inpatients under general medical care in view of the limited examination facilities in the wards. All patients who were in the general medical wards on June 23, 1994, were enrolled for the study. After obtaining informed consent, external genital lesions were identified visually noting the presence of ulcers, warts, and urethral discharge in men. The patients' case notes were reviewed to identify those with known current STDs. A total of 123 patients were examined: 62 males (age range 20-90 years) and 61 females (age range 16-65 years). There were 6 (9.7%) males vs. 8 (13.1%) females with discrete ulcers; no males vs. 2 (3.3%) females had nondiscrete ulcers; 3 (4.8%) males and 6 (9.8%) females had genital warts; 6 (9.7%) males had urethral discharge; and 13 (21%) males vs. 14 (23%) females had one or more lesions. One man had Kaposi's sarcoma of the glans penis. The survey showed that STDS are common in general medical patients in Blantyre with an overall prevalence of 22%. This percentage is an underestimate given the fact that the limited facilities precluded the diagnosis of trichomoniasis, gonorrhea, and chlamydia in women. Of the 123 patients, 14 (11.4%) who had discrete genital ulcers received treatment with erythromycin and penicillin to cover the main possible causes (chancroid, syphilis, and lymphogranuloma venereum). In view of the known link between STDs and the risk of HIV transmission, treatment of STDs may be more effective in preventing sexual transmission of HIV.
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PMID:Prevalence of genital infections in medical inpatients in Blantyre, Malawi. 852 42

A total of 4129 patients attended the STD clinic from 1996 to 1999. Of those 25.75% were STD cases. Male and female cases comprised 86% and 14% respectively. Majority were in the age group between 18 to 38 years. Chancroid was the commonest STD (37.7%). Other STDs in order were syphilis (30.66%), NGU (15.71%), gonorrhoea (7%), venereal wart (3.57%), candidiasis (2.53%), trichomonal vaginitis (1.6%), herpes genitalis (0.65%) and LGV (0.47%). No case of Donovanosis or HIV was detected. 13.7% of STD cases were reactive for VDRL test and 8% of the antenatal attendants were strongly VDRL test reactive. The urethral discharge on gram staining was positive for gonococcus, in 29%. 68% of the clinic attendants were given safer sex education and served condom.
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PMID:A study on the present scenario of STD management in an urban clinic in Kolkata. 1765 84