Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0152030 (
skin irritation
)
2,146
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A role for protein kinase C (PKC)-alpha has been implicated in the growth of mouse hair. Topical application of PKC activators, hair plucking, allergic contact dermatitis and
skin irritation
can all enhance growth of mouse hair, and a significant increase in
PKC-alpha
level in whole mouse skin in mature anagen has been demonstrated in these processes. Overexpression of
PKC-alpha
in anagen hair follicles has also been reported in natural growth of mouse hair. It is known that overexpression of
PKC-alpha
is associated with the acceleration of cell growth. Therefore, we postulated that overexpression of
PKC-alpha
in mature anagen may relate to enhancement of hair growth. The distribution of
PKC-alpha
in hair follicles during induced growth of mouse hair has not previously been studied. In this study, hair growth in C57BL/6 mice was induced by plucking the telogen hairs on one side of the back. The undepilated contralateral side served as a control. Expression of
PKC-alpha
in hair follicles during the hair growth cycle induced was evaluated by immunohistochemistry using cryosections and a specific polyclonal anti-
PKC-alpha
immunoglobulin G (IgG) antibody. No
PKC-alpha
was detected in telogen hair follicles or in the hair follicles at 1 day post-depilation, when the induced hair cycle was in early anagen. At 4 days after plucking, when the induced hair cycle was in mid-anagen, intense staining for
PKC-alpha
was found in hair papillae. At 10 and 17 days after depilation, when the induced hair cycle was in mature anagen and early catagen, respectively, all outer root sheath (ORS) cells and outer connective sheaths of hair follicles were stained positive. Because no
PKC-alpha
was detected in telogen hair follicles in this study, down-regulation of
PKC-alpha
in early anagen could not be observed. However, consistent with our previous findings, overexpression of
PKC-alpha
was found in mid-anagen and mature anagen. As overexpression of
PKC-alpha
has been shown to be associated with acceleration of cell growth, our results support the notion that
PKC-alpha
may play an important role in growth of hair follicle cells in induced growth of hair. As PKC levels are known to increase in hyperglycaemia, overexpressed
PKC-alpha
in mature anagen hair follicles may be related to the putative function of the ORS in mobilizing glycogen stores for anagen growth.
...
PMID:Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair. 1282 8
