Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0152030 (
skin irritation
)
2,146
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Eugenol is a phytochemical present in aromatic plants has generated considerable interest in the pharmaceutical industries mainly in cosmetics. A series of eugenol esters (
ST1
-ST7) and chloro eugenol (
ST8
) have been synthesized. The structures of newly synthesized compounds were confirmed by
1
H and
13
C NMR and mass spectrometry. In an effort to evaluate the pharmacological activity of eugenol derivatives, we explored its anti-inflammatory potential against skin inflammation using
in-vitro
and
in-vivo
bioassay. Synthesized derivatives significantly inhibited the production of pro-inflammatory cytokines against LPS-induced inflammation in macrophages. Among all derivatives,
ST8
[Chloroeugenol (6-chloro, 2-methoxy-4-(prop-2-en-1-yl)-phenol)] exhibited most potent anti-inflammatory activity without any cytotoxic effect. We have further evaluated the efficacy and safety in in-vivo condition.
ST8
exhibited significant anti-inflammatory activity against TPA-induced skin inflammation without any
skin irritation
effect on experimental animals. These findings suggested that
ST8
may be a useful therapeutic candidate for the treatment of skin inflammation.
...
PMID:Synthesis of eugenol derivatives and its anti-inflammatory activity against skin inflammation. 3058 Jun 5
