Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0152030 (skin irritation)
 2,146 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A survey of 322 ileostomates was undertaken to assess the impact of an ileostomy and determine problems that are encountered by patients. Most patients (72 percent) felt they led normal lives with the ileostomy and encountered fewer restrictions in life-style than with their disease. However, only 35 percent of patients felt their ileostomies functioned perfectly. Skin irritation (49 percent), offensive noise and odor (42 percent), detection of the appliance (17 percent), and difficulty in handling the appliance (29 percent) were some of the problems encountered. Psychologic problems were related to poor body image (22 percent) and sterility or impotence (12 percent). All of these problems, however, were less than had been anticipated. Various sources of information were available to the ileostomate. However, about 50 percent of patients felt they received inadequate preoperative information or counseling.
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PMID:Patient evaluation of the conventional ileostomy. 397 18

This paper reports the first clinical safety study of human tolerance of electrical sensation using non-invasive, flexible surface-type electrodes and exponentially decaying electric pulses. The study evaluated the effect of electric fields in the absence of a drug and an anesthetic, and was performed in light of potential applications in the field of erectile dysfunction (ED). Twenty impotent patients who had previously received injection or intraurethral therapies were enrolled in the study. Voltage escalations from 50 to 80 V (in 10-V increments) with a single pulse of 3-ms duration were performed with meander-type electrodes placed on the shaft and part of the glans of the penis. The electric fields-induced sensation was assessed via a pain scale from 0 to 10. All 20 patients, who were free to withdraw from the study at any point, completed the voltage escalation study. No clinical safety concerns were apparent and no skin irritation was observed after electric treatment. Our initial study indicates that the pulses in the tested voltage range were well tolerated by most patients. In previous animal experiments under analogous experimental conditions, the application of 50 V has been found effective for transdermal drug delivery into the penis.
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PMID:Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes. 1200 82