Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151825 (bone pain)
3,118 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
alkaline phosphatase 279
Sep 190
parathyroid hormone 141
She 103
calcitonin 87
granulocyte colony-stimulating factor 87
Mol 69
MRI 54
hemoglobin 53
CSF 47
granulocyte 45
G-CSF 42
PTH 39
prostate-specific antigen 39
FDG 33
RANKL 33
cytokine 32
osteocalcin 32
chronic renal failure 31
RANK 29
non-Hodgkin's lymphoma 28
granulocyte-macrophage colony-stimulating factor 26
Walker 26
osteoprotegerin 26
interferon 25
PSA 25
osteosarcoma 25
MDP 24
type I collagen 24
parathormone 24
acid phosphatase 23
glucocerebrosidase 23
collagen 22
CD34 22
imiglucerase 22
lactate dehydrogenase 20
Calcitonin 19
aromatase 18
C-reactive protein 17
FGF23 17
parathyroid hormone-related protein 17
prostate specific antigen 17
LDH 16
OPG 16
HLA 15
lymphoid 15
GM-CSF 15
LHRH 14
prostatic acid phosphatase 14
ALP 14
somatostatin 13
granulocyte colony stimulating factor 13
TNF 12
cage 12
interleukin-6 12
albumin 12
tumor necrosis factor 12
IL-6 12
IL-1 12
growth hormone 12
IgA 12
MAPK 12
nerve growth factor 11
prolactin 11
ferritin 11
white cell 11
ALL 11
mast cell 11
erythroid 10
reserved 10
interferon-alpha 10
BRAF 10
CD4 10
all-trans 10
interferon alpha 10
macrophage colony-stimulating factor 9
PHEX 9
Men 9
M-protein 9
ATP 9
more...
Disease
cancer 824
tumor 454
bone metastases 422
metastases 383
multiple myeloma 330
hypercalcemia 326
bone disease 313
prostate cancer 289
breast cancer 278
osteoporosis 209
osteomalacia 207
carcinoma 167
anemia 160
PDB 136
hyperparathyroidism 120
spinal cord compression 118
thrombocytopenia 108
leukemia 97
pathological fracture 91
osteomyelitis 82
neutropenia 82
lymphoma 79
Gaucher disease 74
renal failure 71
pruritus 67
bone cancer 61
acute lymphoblastic leukemia 59
rash 56
rickets 56
lung cancer 53
primary hyperparathyroidism 52
lymphadenopathy 51
chronic pain 49
dysplasia 47
metastatic breast cancer 47
adenoma 46
tumor growth 43
arthritis 42
depression 41
sickle cell disease 41
osteosclerosis 39
chronic renal failure 39
wasting 38
vitamin D deficiency 37
osteoarthritis 37
Tumor-induced osteomalacia 36
adenocarcinoma 35
renal insufficiency 35
acute myeloid leukemia 34
Erdheim-Chester disease 34
osteitis 33
Prostate Cancer 32
Schnitzler syndrome 32
renal disease 32
myelodysplastic syndrome 31
leukopenia 31
non-Hodgkin's lymphoma 29
pancytopenia 28
osteosarcoma 28
paraneoplastic syndrome 28
Fanconi syndrome 27
Hodgkin's disease 27
gammopathy 26
myelosuppression 26
hypertension 26
primary tumor 26
hypercalcemia of malignancy 25
PSA 25
renal cell carcinoma 24
rare disease 24
Langerhans cell histiocytosis 24
renal osteodystrophy 24
osteogenesis imperfecta 24
prostatic adenocarcinoma 23
acute leukemia 23
hematologic malignancies 23
periostitis 23
chronic myeloid leukemia 22
proteinuria 22
Fanconi 22
more...
Symptom
bone pain 3118
pain 809
weakness 170
fatigue 131
headache 88
cancer pain 68
arthralgia 66
nausea 62
analgesia 50
myalgia 50
splenomegaly 49
diarrhea 47
back pain 43
vomiting 41
abdominal pain 33
dyspnea 33
hepatosplenomegaly 32
anorexia 25
hepatomegaly 23
collapse 21
flushing 20
Ill 20
constipation 18
nausea and vomiting 17
seizures 15
discomfort 15
discomfort 15
chest pain 15
low back pain 14
insomnia 14
night sweats 14
polyuria 14
asthenia 13
pallor 13
paresthesia 13
anesthesia 12
clubbing 12
lethargy 12
polydipsia 12
cough 12
erythema 11
chills 11
hip pain 11
dizziness 10
prostatism 9
acute pain 9
cachexia 9
fever of unknown origin 8
sleepiness 7
leg pain 7
shortness of breath 7
hemoptysis 6
breakthrough pain 6
knee pain 5
dysuria 5
epigastric pain 5
hoarseness 5
hot flashes 5
tinnitus 5
numbness 5
Neuropathic pain 4
Spots 4
muscle cramps 4
abnormal gait 4
respiratory distress 4
shoulder pain 4
thinning 4
abdominal discomfort 4
dry skin 4
hot flushes 4
paraparesis 4
paresis 4
nasal congestion 4
acidity 3
joint stiffness 3
ataxia 3
Flare 3
vertigo 3
wheezing 3
chronic cough 3
more...
Drug
G-CSF 63
CSF 58
Zoledronic acid 52
Zoledronic acid 47
PTH 39
EHDP 38
Clodronate 24
Filgrastim 18
APD 18
Ibandronate 16
Dermatol 14
Filgrastim 13
Denosumab 13
Aredia 13
SrCl2 11
CTX 10
Dial 10
ascorbate 9
Zoladex 8
Zoladex 8
ICI 7
CTX 7
CTX 7
Leaf 6
MRC 6
Adriamycin 6
Gallium nitrate 5
Salmon calcitonin 5
Lenograstim 5
Cerezyme 4
PMPA 4
Ceredase 4
Adefovir dipivoxil 4
Cerezyme 4
Quadramet 4
Bortezomib 3
VCR 3
Prednisone 3
IFN-gamma 3
caffeine 3
Rituximab 3
p75 3
Estracyt 3
Docetaxel 3
SrCl2 3
lysine 3
IL-1ra 3
Estracyt 3
Lenalidomide 3
Tenofovir disoproxil fumarate 3
Lupron 2
Alliance 2
MAP 2
Taxol 2
Asthma 2
-deoxyadenosine 2
Bonefos 2
Nephron 2
ENT 2
Glucagon 2
Lanthanum carbonate 2
Anakinra 2
Cinacalcet 2
Fosamax 2
Prednisolone 2
PMEA 2
ProstaScint 2
Vinorelbine 2
Skelid 2
Ipriflavone 2
Gefitinib 2
Vindesine 2
Vindesine 2
Spectrum 2
MDS 2
IL-2 2
Skelid 2
Luteinizing 1
Bavituximab 1
Sandostatin 1
more...
Enzyme
alkaline phosphatase 279
prostate-specific antigen 36
lactate dehydrogenase 25
ERK 24
MDP 24
acid phosphatase 23
mitogen-activated protein kinase 23
glucocerebrosidase 19
focal adhesion kinase 8
cathepsin K 8
CD10 6
proteasome 6
prostate-specific membrane antigen 5
aspartate aminotransferase 5
calcineurin 5
protein kinase 5
alanine aminotransferase 4
trypsin 4
creatine kinase 4
ATPase 4
protein kinase C 3
luciferase 3
MEK 3
CaMKII 3
peroxidase 3
elastase 2
monoacylglycerol lipase 2
AST 2
beta-glucosidase 2
BMT 2
beta-glucosidase 2
granzyme B 2
MIP 2
HOA 2
tryptase 2
gamma-glutamyl transpeptidase 2
reverse transcriptase 1
urokinase-type plasminogen activator 1
LMT 1
MAT 1
SMP 1
PARP 1
glutamate dehydrogenase 1
pepsin 1
inositol 3-kinase 1
isopeptidase 1
HDR 1
protein phosphatase 2A 1
caspase-3 1
renin 1
lipase 1
legumain 1
thymidine phosphorylase 1
superoxide dismutase 1
ACE 1
IKK 1
thrombin 1
adenylate cyclase 1
lysozyme 1
ACS 1
FPS 1
tyrosine hydroxylase 1
catalase 1
plasmin 1
phosphoinositide 3-kinase 1
complex I 1
topoisomerase 1
glutamate dehydrogenase 1
ribonucleotide reductase 1
P-glycoprotein 1
MAT 1
TdT 1
ribonucleotide reductase 1
glutamate dehydrogenase 1
topoisomerase 1
DNA methyltransferase 1
carboxypeptidase G2 1
thymidine kinase 1
Compound
Clin 379
calcium 349
Dec 225
phosphate 190
vitamin D 158
phosphorus 99
strontium 74
creatinine 54
sodium 48
aluminum 37
EHDP 33
His 30
nitrogen 27
Pamidronate 27
acetate 27
DNA 24
Vitamin D 19
Calcitonin 19
iron 19
retinoic acid 18
water 15
ALP 14
iodine 13
potassium 13
25-dihydroxycholecalciferol 13
TNF 12
oxygen 12
glutamate 12
glucose 11
CTX 10
Dial 10
Morphine 9
urea 9
carbonate 9
MDA 9
ATP 9
Adriamycin 9
A 42 8
Alendronate 8
phosphoric acid 7
fluorine 7
ICI 7
NH2 7
hydroxide 7
cAMP 6
Hemoglobin 6
Risedronate 6
Alendronate 6
Mithramycin 6
Androgen 6
Paclitaxel 5
sulfate 5
salt 5
5-FU 5
Optimal 5
BMD 5
HNO3 5
tin 5
1,4,7,10-tetraazacyclododecane 5
ADR 5
Voriconazole 5
Hydroxyurea 4
AMP 4
Aminoglutethimide 4
cysteine 4
L-PAM 4
lysine 4
DTPA 4
APAP 4
tyrosine 4
Estracyt 4
nitrate 4
Parenteral 4
ACTH 4
ethanol 4
zinc 4
cadmium 4
L-PAM 4
MTT 4
DIC 4
more...