Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151825 (bone pain)
 3,118 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
FBLIM1 11.0
ZNF687 9.9
PSA2 9.6
killer-specific secretory protein of 37 kDa 9.5
SCN7A 9.4
CTMP 9.4
AIP2 9.3
bone-type alkaline phosphatase 9.3
SLC34A3 9.2
TNFRSF11A 9.2
ADAMTS14 9.1
Endomucin 8.9
transforming growth factor beta receptor 1 8.9
Granulocyte colony stimulating factor 8.9
imiglucerase 8.9
PSTPIP2 8.8
TBXAS1 8.8
Visinin-like protein 1 8.7
MTBP 8.5
PHEX 8.4
PTH2 8.4
ARL6 8.4
infantile malignant osteopetrosis 8.3
Granulocyte-colony stimulating factor 8.3
MAPK11 8.0
LPIN2 8.0
FIP1 8.0
PSA1 7.9
CNTN3 7.9
PFN1 7.7
VMP 7.7
secreted frizzled-related protein 4 7.6
GALNT3 7.5
WISP-1 7.4
Protease-activated receptor 2 7.4
phosphatonin 7.3
FGF23 7.3
monocarboxylate transporter 4 7.3
vacuolar proton pump 7.3
granulocyte colony stimulating factor 7.2
CLCN7 7.2
BGP 7.2
histone deacetylase 8 7.1
EMP 7.1
RANK 7.1
parathormone 7.1
chitotriosidase 7.0
Period 3 7.0
GPNMB 7.0
granulocyte colony-stimulating factor 6.9
MDP 6.9
glucocerebrosidase 6.8
matrix extracellular phosphoglycoprotein 6.8
XLMR 6.8
SET7/9 6.8
OPG 6.8
CDT1 6.8
TRAF4 6.7
OPS 6.7
protease-activated receptor 4 6.7
prostatic acid phosphatase 6.7
Nav1.3 6.7
ALPL 6.7
CCL15 6.6
P2X4R 6.6
M-protein 6.6
CCN3 6.6
HOA 6.6
CD100 6.6
PARC 6.5
IL-17E 6.5
SGD 6.5
ARH-77 6.5
ASIC3 6.5
HLA-Cw 6.4
interferon alpha 2b 6.4
parathyroid hormone 6.4
PML/RAR alpha 6.4
FN1 6.4
FcRIII 6.4
G-CSF 6.4
Calcitonin 6.4
heterogeneous nuclear ribonucleoprotein A1 6.4
ung 6.3
osteoprotegerin 6.3
PTH1 6.3
P2X5 6.3
CAMKII 6.3
CITED2 6.3
DC-STAMP 6.2
acute myeloid leukemia 1 6.2
thrombospondin 2 6.1
prokineticin 2 6.1
OPTN 6.1
IgL 6.1
parathyroid hormone-related protein 6.1
hephaestin 6.1
prostate specific antigen 6.1
FGR 6.1
renal) 6.0
CD66 6.0
RANKL 6.0
Acid phosphatase 5.9
CCL18 5.9
SNS 5.9
Ki-1 5.9
RUNX1T1 5.9
ASIC1 5.9
alkaline phosphatase 5.9
PTH 5.9
NTRK1 5.8
Silver syndrome 5.8
PH1 5.8
prostate-specific antigen 5.7
xCT 5.7
GTX 5.7
tyrosine kinase 2 5.7
calcitonin 5.7
P2X4 5.7
SLC7A11 5.7
IB2 5.7
RAI 5.7
HBP 5.6
gp17 5.6
TDF 5.6
GNAS 5.6
Cap43 5.6
NOV 5.6
MED12 5.6
TTF1 5.6
PSA 5.5
Walker 5.5
DMP1 5.5
ubiquitin C-terminal hydrolase 5.5
receptor protein tyrosine kinase 5.5
RAMP1 5.5
PEDF 5.5
VCP 5.5
sequestosome 1 5.5
PRISM 5.5
cathepsin K 5.5
Prostate specific antigen 5.5
tissue-nonspecific alkaline phosphatase 5.4
FACT 5.4
TP5 5.4
artemin 5.4
white cell 5.4
sclerostin 5.4
VAMP 5.3
Dickkopf-1 5.3
TNFRSF1A 5.3
HPT 5.3
CPX 5.3
granulocyte-macrophage colony-stimulating factor 5.3
HBD 5.3
HDS 5.3
somatostatin receptor 5.3
COL1A2 5.2
CSF1 5.2
mammaglobin 5.2
more...
Disease
Periostitis deformans 13.3
Stage IV Prostate Adenocarcinoma 13.3
High turnover osteopathy 13.3
Acquired Fanconi syndrome 12.0
Looser-Milkman 11.7
Non-Langerhans cell histiocytosis 11.7
Polyostotic fibrous dysplasia 11.4
Schnitzler syndrome 11.3
Tumor-induced osteomalacia 11.2
phosphaturic mesenchymal tumor 11.1
Brainstem compression 11.0
Chronic leg ulcer 11.0
SLC34A3, 10.9
cancer seeding 10.7
HHRH 10.7
Fibrous dysplasia of bone 10.7
IgM gammopathy 10.7
Biclonal gammopathy 10.5
Aromatase deficiency 10.5
Intra-abdominal metastases 10.3
Paget's Disease 10.1
Uremic encephalopathy 9.9
Bone marrow edema syndrome 9.7
HIV neuropathy 9.7
stage D prostate cancer 9.6
urinary tract neoplasm 9.6
Psychological dependence 9.5
Hepatic osteodystrophy 9.5
Erdheim-Chester disease 9.4
bone metastases 9.4
osteomalacia 9.4
Tertiary syphilis 9.3
bone cancer 9.2
Joint infection 9.2
Pulmonary fat embolism 9.2
hypercalcemia of malignancy 9.2
Myeloid metaplasia 9.1
Dialysis dementia 9.1
pathological fracture 9.1
neuroblastoma stage 9.1
esophageal irritation 9.0
Membranous lipodystrophy 8.9
periostitis 8.9
Acute myelofibrosis 8.9
ATRA syndrome 8.8
osteosclerosis 8.8
craniotabes 8.8
Fibrous dysplasia 8.8
bone disease 8.7
Nutritional anemia 8.7
IgG gammopathy 8.7
hypertrophic osteoarthropathy 8.7
Hypertrophic pulmonary osteoarthropathy 8.7
spinal cord compression 8.7
leukoerythroblastosis 8.6
bone marrow metastases 8.5
Disseminated coccidioidomycosis 8.5
aregenerative anemia 8.5
stage C prostate cancer 8.5
Bone marrow toxicity 8.5
hypercalcemia 8.3
Algodystrophy 8.3
Dense deposit disease 8.3
nasopharyngeal lymphoepithelioma 8.3
malignant myeloma 8.2
Bone marrow edema 8.2
stage III breast cancer 8.1
Malignant pheochromocytoma 8.1
osteodystrophy 8.0
Hypervitaminosis A 8.0
Gaucher disease 8.0
hypophosphaturia 8.0
Parvovirus infection 7.9
IBMPFD 7.8
Lymphangiomatosis 7.8
hormone refractory prostate cancer 7.8
Secondary hyperparathyroidism 7.8
Brown tumor 7.8
hypophosphatasia 7.8
Tuberculous osteomyelitis 7.8
vitamin D-resistant rickets 7.7
slow virus infection 7.7
Microangiopathic hemolytic anemia 7.7
Cutaneous mastocytosis 7.7
Erosive gastritis 7.7
plasma cell leukemia 7.7
PDB 7.7
stage I ovarian cancer 7.7
Mastocytosis 7.7
Pseudomonas septicemia 7.6
sphingolipidosis 7.6
phosphaturia 7.6
dysproteinemia 7.6
Breast metastases 7.6
Parathyroid gland 7.6
Parathyroid gland 7.6
Parathyroid gland 7.6
T3 toxicosis 7.6
cystic ovary 7.6
arthritis of the hip 7.5
Reifenstein syndrome 7.5
renal osteodystrophy 7.5
HYP 7.5
pseudoglioma 7.5
paraneoplastic syndrome 7.5
IgM MGUS 7.5
battered child syndrome 7.5
osteitis 7.5
Parathyroid carcinoma 7.5
glue sniffing 7.4
urticaria pigmentosa 7.4
Parathyroid adenoma 7.4
Systemic mastocytosis 7.4
rickets 7.4
Fanconi syndrome 7.4
chronic urticaria 7.4
Metabolic bone disease 7.4
Langerhans cell sarcoma 7.4
scurvy 7.4
HOA 7.3
Endogenous endophthalmitis 7.3
Spinal metastases 7.3
acroparesthesia 7.3
Caffey's disease 7.3
SAPHO syndrome 7.3
ML III 7.3
nerve root compression 7.2
melorheostosis 7.2
osteoarthropathy 7.2
intraocular retinoblastoma 7.2
heritable connective tissue disorder 7.1
Bone fragility 7.1
Histoplasma capsulatum infection 7.1
hyperparathyroidism 7.1
bone neoplasm 7.1
parathyroid hyperplasia 7.1
Leukemia cutis 7.1
NHD 7.0
c-ALL 6.9
metastatic neuroblastoma 6.9
capsulitis 6.9
aminoaciduria 6.9
Bacillary angiomatosis 6.9
periostosis 6.9
OPS 6.9
hypotension and shock 6.9
mast cell leukemia 6.9
plasmacytosis 6.9
Azotemia 6.9
NSHL 6.9
chronic neutrophilic leukemia 6.9
acute osteomyelitis 6.8
extramedullary plasmacytoma 6.8
AML/MDS 6.8
metastatic neuroblastoma 6.8
gammopathy 6.8
primary hyperparathyroidism 6.8
Jaccoud 6.7
evaluable disease 6.7
arthritis of the knee 6.7
more...
Symptom
Girdle pain 13.3
bone pain 13.3
Bone swelling 12.3
Metastatic bone pain 12.0
Upper back pain 10.7
rib pain 8.9
prostatism 8.3
ENT symptoms 7.9
cancer pain 7.8
carpopedal spasm 7.8
musculoskeletal disability 7.8
epigastric distress 7.7
Flu-like symptoms 7.5
General symptoms 7.4
Flare 7.4
breakthrough pain 7.2
clubbing 7.1
night sweats 6.9
jaw pain 6.8
Neurologic symptoms 6.8
lassitude 6.8
growing pains 6.7
Musculoskeletal symptoms 6.6
arthralgia 6.6
Spots 6.5
myalgia 6.3
hepatosplenomegaly 6.2
generalized rash 6.2
Severe pain 6.0
hip pain 6.0
polydipsia 5.8
pallor 5.7
generalized pain 5.7
splenomegaly 5.7
asthenia 5.6
hot flashes 5.6
polyuria 5.5
weakness 5.5
muscle cramps 5.5
physical symptom 5.4
hepatomegaly 5.3
groin pain 5.3
dry skin 5.3
periorbital edema 5.3
fever of unknown origin 5.3
back pain 5.2
abnormal gait 5.2
nasal congestion 5.2
visual hallucination 5.1
leg pain 5.1
pleuritic chest pain 5.1
elbow pain 5.1
hot flushes 5.0
flushing 5.0
pain 5.0
limb pain 4.9
testicular pain 4.9
joint stiffness 4.9
Neuropathic pain 4.8
nausea 4.8
eye pain 4.7
paresthesia 4.7
mastalgia 4.7
chills 4.7
fatigue 4.7
dental pain 4.7
rigors 4.6
belching 4.6
abdominal discomfort 4.6
acute pain 4.5
orthopnea 4.5
heel pain 4.4
lethargy 4.4
tenesmus 4.4
dysuria 4.4
arm pain 4.3
lightheadedness 4.3
abdominal cramps 4.3
hyperemesis gravidarum 4.2
anorexia 4.2
Ill 4.2
knee pain 4.2
analgesia 4.2
nausea and vomiting 4.2
constipation 4.2
Gastrointestinal symptoms 4.1
decreased appetite 4.1
hoarseness 4.1
halitosis 4.1
presyncope 4.1
cachexia 4.0
headache 4.0
thigh pain 3.9
forgetfulness 3.9
chronic cough 3.9
right upper quadrant pain 3.9
epigastric pain 3.9
paraparesis 3.9
shoulder pain 3.9
low back pain 3.8
shortness of breath 3.8
chronic back pain 3.8
insomnia 3.8
anosmia 3.7
chest tightness 3.7
vomiting 3.7
renal colic 3.7
consciousness disturbance 3.6
dyspnea 3.6
abdominal pain 3.4
dizziness 3.4
Stiffness 3.4
hemoptysis 3.3
numbness 3.3
hypersomnia 3.3
Postoperative pain 3.2
urinary frequency 3.2
rhinorrhea 3.2
chest pain 3.2
erythema 3.1
diarrhea 3.1
tingling 3.0
tinnitus 3.0
apathy 2.9
collapse 2.9
sore throat 2.9
myoclonus 2.8
paresis 2.8
discomfort 2.8
sciatica 2.7
photophobia 2.7
wheezing 2.7
discomfort 2.6
enuresis 2.6
sleepiness 2.5
oliguria 2.5
cough 2.4
Depressive symptoms 2.4
blurred vision 2.3
spasticity 2.2
flank pain 2.2
facial pain 2.1
vertigo 2.1
tachypnea 2.0
masculinization 2.0
dry eye 2.0
thinning 1.9
acute abdomen 1.7
syncope 1.7
memory loss 1.5
spasm 1.5
cyanosis 1.4
neck pain 1.4
agitation 1.3
pelvic pain 1.3
respiratory distress 1.1
acidity 1.0
ataxia 0.9
seizures 0.9
hunger 0.8
more...
Drug
Skelid 13.3
Skelid 13.3
Quadramet 11.6
Aredia 11.4
Liarozole fumarate 11.3
Stilphostrol 11.0
Stilphostrol 11.0
Miacalcin 10.3
Bonefos 10.2
Bavituximab 10.1
Ibandronate 10.1
Lenograstim 9.9
Clodronate 9.9
Zoledronic acid 9.9
Etidronate disodium 9.7
EHDP 9.6
Cerezyme 9.5
Actonel 9.5
Zoledronic acid 9.4
Gallium nitrate 9.3
ProstaScint 9.3
SrCl2 9.2
Eulexin 9.1
Ceredase 9.1
Filgrastim 8.8
Iguratimod 8.7
Cerezyme 8.6
Risedronate sodium 8.6
Filgrastim 8.6
Adefovir dipivoxil 8.4
Zoladex 8.3
Anandron 8.2
Fosamax 8.1
Salmon calcitonin 8.1
Zoladex 8.0
Estracyt 8.0
Denosumab 7.9
Estracyt 7.9
Lanthanum carbonate 7.8
Rocaltrol 7.8
Iron dextran 7.8
Alfacalcidol 7.8
APD 7.7
Potassium citrate 7.6
SrCl2 7.5
Tenofovir disoproxil fumarate 7.5
Vindesine 7.5
Vindesine 7.4
Ipriflavone 7.3
G-CSF 6.9
Thymopentin 6.9
Deflazacort 6.9
Pyridostigmine bromide 6.9
Bosutinib 6.8
Lupron 6.7
Cinacalcet 6.6
Anakinra 6.3
Aprepitant 6.1
2-Methoxyestradiol 5.9
Opium 5.9
PTH 5.9
Carbenoxolone 5.7
Cetrorelix 5.7
PMPA 5.7
Novantrone 5.7
Vinorelbine 5.6
NOV 5.6
Ethylenediamine 5.6
Lenalidomide 5.6
ARA-C 5.5
Encore 5.4
Sandostatin 5.1
Sandostatin 5.1
Teriparatide 4.9
Prednisone 4.9
PMEA 4.8
Retinoic Acid 4.8
SMP 4.7
Tenofovir 4.6
IL-1ra 4.5
Bortezomib 4.4
VCR 4.3
CSF 4.3
Vicryl 4.3
MRC 4.2
Docetaxel 4.1
Gefitinib 4.1
Dasatinib 4.1
Urokinase 4.0
VCR 4.0
Isotretinoin 3.9
Prednisolone 3.8
DMSA 3.8
ICI 3.7
Adriamycin 3.7
CTX 3.7
CTX 3.6
Gabapentin 3.5
Gastro 3.5
DEX 3.5
Rituximab 3.4
DDAVP 3.4
DDAVP 3.4
CTX 3.3
-deoxyadenosine 3.3
Luteinizing 3.3
Ketoconazole 3.3
FLP 3.2
Doxycycline 3.2
MDS 3.2
Infliximab 3.2
Infliximab 3.2
DPA 3.0
p75 3.0
NBT 2.9
Alliance 2.9
Bayer 2.7
Taxol 2.7
Tacrolimus 2.6
PTC 2.5
TTC 2.5
Glucagon 2.4
ADR 2.3
uPA 2.3
NAG 2.2
Estrogens 2.2
Imatinib 2.0
ascorbate 2.0
HCG 1.9
ETA 1.9
Vitamin A 1.7
Dial 1.7
Retinoic acid 1.6
Leaf 1.5
Spectrum 1.4
ENT 1.3
Albumin 1.1
Histamine 0.9
Mutagen 0.8
EPA 0.5
caffeine 0.5
ROC 0.4
EE2 0.4
MAP 0.4
Nephron 0.2
IFN-gamma 0.1
Nephron -0.2
Asthma -0.3
IL-2 -0.5
lactose -0.7
Dermatol -0.9
lysine -0.9
Cardiovasc -4.3
Enzyme
HOA 7.3
glucocerebrosidase 7.0
LMT 6.5
MDP 6.5
alkaline phosphatase 5.9
carboxypeptidase G2 5.8
prostate-specific antigen 5.7
inositol 3-kinase 5.5
cathepsin K 5.5
monoacylglycerol lipase 4.9
FPS 4.9
prostate-specific membrane antigen 4.9
legumain 4.7
acid phosphatase 4.2
isopeptidase 4.2
HDR 4.1
SMP 3.9
thymidine phosphorylase 3.3
lactate dehydrogenase 3.1
BMT 2.9
CaMKII 2.9
tryptase 2.9
beta-glucosidase 2.8
MAT 2.8
CD10 2.6
beta-glucosidase 2.6
granzyme B 2.6
MAT 2.6
TdT 2.4
MIP 2.1
ribonucleotide reductase 1.8
ribonucleotide reductase 1.8
protein phosphatase 2A 1.8
AST 1.8
calcineurin 1.6
ERK 1.4
mitogen-activated protein kinase 1.3
aspartate aminotransferase 1.2
glutamate dehydrogenase 1.2
glutamate dehydrogenase 1.2
glutamate dehydrogenase 1.2
gamma-glutamyl transpeptidase 1.2
elastase 1.2
creatine kinase 1.1
proteasome 1.1
IKK 1.1
DNA methyltransferase 1.0
focal adhesion kinase 0.9
phosphoinositide 3-kinase 0.8
MEK 0.8
alanine aminotransferase 0.6
thymidine kinase 0.4
pepsin 0.2
complex I 0.2
plasmin 0.2
topoisomerase 0.2
topoisomerase 0.0
trypsin -0.0
urokinase-type plasminogen activator -0.1
luciferase -0.3
P-glycoprotein -0.4
PARP -0.4
tyrosine hydroxylase -0.5
protein kinase -0.7
ATPase -0.7
protein kinase C -0.7
ACE -0.8
lipase -0.9
adenylate cyclase -0.9
lysozyme -1.1
peroxidase -1.1
reverse transcriptase -1.6
thrombin -1.7
caspase-3 -1.8
renin -1.8
catalase -2.4
superoxide dismutase -2.5
ACS -2.9
Compound
Stilphostrol 11.0
Nilutamide 10.1
Pamidronate 10.0
Tiludronate 10.0
EHDP 9.6
Risedronate 8.4
Mithramycin 8.2
Melarsoprol 8.0
Estracyt 7.9
Estracyt 7.9
Nafarelin 7.9
3-O-methyldopamine 7.9
BMN 7.6
Aminoglutethimide 7.6
T 12 7.5
Tetracycline hydrochloride 7.4
2,3-diaminopropanoic acid 7.3
2,3-diaminopropanoic acid 7.2
strontium 7.1
Alendronate 7.1
CHQ 7.0
Oxycodone 6.9
DR-1 6.8
Alendronate 6.8
RUB 6.7
Paricalcitol 6.6
Glucosylceramide 6.4
Calcitonin 6.4
Leuprolide 6.4
MCNU 6.3
Sinomenine 6.1
Mexiletine 6.1
Voriconazole 6.1
Dehydroepiandrosterone sulfate 6.0
2-Methoxyestradiol 5.9
1,4,7,10-tetraazacyclododecane 5.9
25-dihydroxycholecalciferol 5.9
vitamin D 5.9
L-PAM 5.7
L-PAM 5.7
8-quinolinol 5.6
CLS 5.3
LY 294002 5.2
Hydroxyurea 5.1
HMS 5.1
Letrozole 5.1
ALP 5.1
1,4,8,11-tetraazacyclotetradecane 5.0
HPT 4.9
Vitamin D 4.9
FUDR 4.8
A 42 4.8
HNO3 4.7
Labetalol 4.7
25-hydroxycholecalciferol 4.7
Topotecan 4.7
LCR 4.7
Alizarin Red S 4.6
BAP 4.6
DHF 4.5
Docetaxel 4.5
phosphorus 4.4
Cortisone 4.4
Tin 4.4
Hydroxychloroquine 4.4
Baicalein 4.4
PMEA 4.4
Androgen 4.3
Sudan I 4.2
Prednisone 4.2
A 71 4.2
Morphine 4.2
Paclitaxel 4.2
Topotecan 4.2
Parenteral 4.1
Vinblastine 4.0
Mitoxantrone 4.0
Naproxen 4.0
Tempol 4.0
Heroin 4.0
ACNU 4.0
Mitoxantrone 4.0
DIC 4.0
Albendazole 3.9
BMD 3.9
gamma-hydroxybutyric acid 3.9
MPA 3.9
Vinca 3.9
TTS 3.9
MPA 3.9
Brilliant Blue 3.9
MPA 3.8
Prednisolone 3.8
HBB 3.8
aluminum 3.7
SSD 3.7
Ara-C 3.7
Vitamin D3 3.7
cyclohexanol 3.7
TACE 3.7
cyclohexanol 3.6
AEA 3.6
4-hydroxybenzoic acid 3.6
CHIP 3.6
Vitamin D3 3.6
DDC 3.5
T11 3.5
Suramin 3.5
ICI 3.5
Adriamycin 3.5
phosphate 3.5
calcium 3.4
Coumarin 3.4
2,2,6,6-tetramethylpiperidine 3.4
FDP 3.4
Octreotide 3.4
PSP 3.4
Ketoconazole 3.3
T 1 3.3
CTX 3.3
Ara-C 3.3
Guo 3.3
TAR 3.3
Bromocriptine 3.3
RU-486 3.2
Doxycycline 3.2
benzonitrile 3.2
DPA 3.2
HBr 3.2
creatinine 3.2
DPA 3.2
Hydroxyproline 3.2
SET 3.2
BCNU 3.2
Carnitine 3.2
Belt 3.1
Hemoglobin 3.1
Baclofen 3.1
phenylacetic acid 3.1
DPA 3.1
ADR 3.0
FTA 3.0
DPG 3.0
CAP 3.0
DPA 3.0
DSS 3.0
DPA 3.0
AEA 3.0
DEN 3.0
DFO 3.0
Capsaicin 2.9
APAP 2.9
retinoic acid 2.9
PAP 2.9
CES 2.9
DPA 2.9
Argentine 2.9
CIT 2.9
CBDCA 2.9
CBDCA 2.9
more...