Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151825 (bone pain)
 3,118 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
alkaline phosphatase 279
Sep 190
parathyroid hormone 141
She 103
granulocyte colony-stimulating factor 87
calcitonin 87
Mol 69
MRI 54
hemoglobin 53
CSF 47
granulocyte 45
G-CSF 42
prostate-specific antigen 39
PTH 39
RANKL 33
FDG 33
osteocalcin 32
cytokine 32
chronic renal failure 31
RANK 29
non-Hodgkin's lymphoma 28
Walker 26
granulocyte-macrophage colony-stimulating factor 26
osteoprotegerin 26
interferon 25
PSA 25
osteosarcoma 25
type I collagen 24
parathormone 24
MDP 24
acid phosphatase 23
glucocerebrosidase 23
CD34 22
imiglucerase 22
collagen 22
lactate dehydrogenase 20
Calcitonin 19
aromatase 18
parathyroid hormone-related protein 17
C-reactive protein 17
FGF23 17
prostate specific antigen 17
LDH 16
OPG 16
lymphoid 15
GM-CSF 15
HLA 15
prostatic acid phosphatase 14
LHRH 14
ALP 14
somatostatin 13
granulocyte colony stimulating factor 13
growth hormone 12
IL-6 12
albumin 12
IgA 12
TNF 12
cage 12
interleukin-6 12
IL-1 12
MAPK 12
tumor necrosis factor 12
nerve growth factor 11
white cell 11
ferritin 11
ALL 11
prolactin 11
mast cell 11
CD4 10
interferon-alpha 10
BRAF 10
reserved 10
interferon alpha 10
all-trans 10
erythroid 10
PHEX 9
nodal 9
ESR 9
macrophage colony-stimulating factor 9
M-protein 9
ATP 9
X-linked 9
tyrosine kinase 9
Men 9
estrogen receptor 8
chemokine 8
AML 8
p38 8
cathepsin K 8
CD20 8
CD1a 7
CTX 7
somatostatin receptor 7
osteogenic 7
CD8 7
CXCR4 7
erythropoietin 7
Mal 7
BGP 7
brain-derived neurotrophic factor 7
serum protein 7
insulin 7
TNFRSF11A 6
tartrate-resistant acid phosphatase 6
FGFR1 6
serum albumin 6
endoplasmic reticulum 6
TGF-beta 6
phosphatase 6
JAMA 6
proteasome 6
androgen receptor 6
P2X7 6
glycoprotein 6
MRC 6
vitamin D receptor 6
granulocyte-macrophage 6
Acid phosphatase 6
ERK1 6
IFN 6
Alkaline phosphatase 6
calcium channel 6
IgE 6
vascular endothelial growth factor 6
CD68 6
Pol 6
TRPV1 6
substance P 6
C30 6
opioid receptor 5
gut 5
glucagon 5
osteopontin 5
beta-endorphin 5
glial fibrillary acidic protein 5
sclerostin 5
CD56 5
p53 5
BMD 5
CRP 5
Granulocyte-colony stimulating factor 5
kit 5
calcineurin 5
PDB 5
SNS 5
member 1 5
beta 2-microglobulin 5
proximal tubule 5
DIC 5
carcinoembryonic antigen 5
ankylosing spondylitis 5
interleukin-2 5
TNF-alpha 5
CGRP 5
HLA-DR 5
CD38 5
ERK 5
ACTH 5
endothelin-1 4
CD10 4
more...
Disease
cancer 824
tumor 454
bone metastases 422
metastases 383
multiple myeloma 330
hypercalcemia 326
bone disease 313
prostate cancer 289
breast cancer 278
osteoporosis 209
osteomalacia 207
carcinoma 167
anemia 160
PDB 136
hyperparathyroidism 120
spinal cord compression 118
thrombocytopenia 108
leukemia 97
pathological fracture 91
osteomyelitis 82
neutropenia 82
lymphoma 79
Gaucher disease 74
renal failure 71
pruritus 67
bone cancer 61
acute lymphoblastic leukemia 59
rickets 56
rash 56
lung cancer 53
primary hyperparathyroidism 52
lymphadenopathy 51
chronic pain 49
dysplasia 47
metastatic breast cancer 47
adenoma 46
tumor growth 43
arthritis 42
sickle cell disease 41
depression 41
osteosclerosis 39
chronic renal failure 39
wasting 38
osteoarthritis 37
vitamin D deficiency 37
Tumor-induced osteomalacia 36
adenocarcinoma 35
renal insufficiency 35
acute myeloid leukemia 34
Erdheim-Chester disease 34
osteitis 33
renal disease 32
Schnitzler syndrome 32
Prostate Cancer 32
leukopenia 31
myelodysplastic syndrome 31
non-Hodgkin's lymphoma 29
pancytopenia 28
paraneoplastic syndrome 28
osteosarcoma 28
Hodgkin's disease 27
Fanconi syndrome 27
primary tumor 26
myelosuppression 26
hypertension 26
gammopathy 26
PSA 25
hypercalcemia of malignancy 25
osteogenesis imperfecta 24
rare disease 24
Langerhans cell histiocytosis 24
renal osteodystrophy 24
renal cell carcinoma 24
prostatic adenocarcinoma 23
acute leukemia 23
periostitis 23
hematologic malignancies 23
hypercalciuria 22
sepsis 22
proteinuria 22
chronic myeloid leukemia 22
Fanconi 22
neuroblastoma 22
tumor progression 21
plasmacytoma 21
myopathy 20
chronic urticaria 20
malabsorption 19
disseminated intravascular coagulation 18
MAS 18
phosphaturic mesenchymal tumor 17
myelofibrosis 17
hypertrophic osteoarthropathy 17
renal impairment 17
Best 17
sepsis 17
hyperostosis 16
hepatocellular carcinoma 16
Fibrous dysplasia 16
osteodystrophy 16
periosteum 16
non-small cell lung cancer 16
mastocytosis 16
HIV 15
diabetes insipidus 15
influenza 15
osteoarthropathy 15
pneumonia 15
deafness 15
cold 15
urticaria 15
hyperphosphatemia 15
amyloidosis 15
acute promyelocytic leukemia 14
AIDS 14
melanoma 13
diabetes 13
IgM gammopathy 13
immunodeficiency 13
thyroid cancer 13
rheumatoid arthritis 13
heart failure 13
hypophosphatasia 13
malnutrition 12
chronic lymphocytic leukemia 12
chronic hepatitis 12
nephrolithiasis 12
neuropathy 12
hypoparathyroidism 12
graft-versus-host disease 12
Crohn's disease 11
thalassemia 11
plasma cell leukemia 11
B-cell lymphoma 11
macroglobulinemia 11
scurvy 11
sarcoma 11
phosphaturia 11
genetic disorder 11
Leukemia 11
HYP 11
chronic lymphocytic leukemia 11
dengue 11
monoclonal gammopathy of undetermined significance 11
uremia 11
infectious diseases 11
confusion 11
osteoma 10
tuberculosis 10
peripheral neuropathy 10
nephrocalcinosis 10
addiction 9
lung metastases 9
sarcoidosis 9
Frey 9
myeloproliferative disorders 9
hepatitis B 9
aplastic anemia 9
cirrhosis 9
solid tumor 9
more...
Symptom
bone pain 3118
pain 809
weakness 170
fatigue 131
headache 88
cancer pain 68
arthralgia 66
nausea 62
myalgia 50
analgesia 50
splenomegaly 49
diarrhea 47
back pain 43
vomiting 41
dyspnea 33
abdominal pain 33
hepatosplenomegaly 32
anorexia 25
hepatomegaly 23
collapse 21
Ill 20
flushing 20
constipation 18
nausea and vomiting 17
seizures 15
chest pain 15
discomfort 15
discomfort 15
night sweats 14
low back pain 14
polyuria 14
insomnia 14
asthenia 13
paresthesia 13
pallor 13
polydipsia 12
clubbing 12
anesthesia 12
cough 12
lethargy 12
chills 11
hip pain 11
erythema 11
dizziness 10
acute pain 9
cachexia 9
prostatism 9
fever of unknown origin 8
leg pain 7
shortness of breath 7
sleepiness 7
breakthrough pain 6
hemoptysis 6
hot flashes 5
epigastric pain 5
knee pain 5
hoarseness 5
dysuria 5
tinnitus 5
numbness 5
Neuropathic pain 4
abdominal discomfort 4
thinning 4
paraparesis 4
hot flushes 4
dry skin 4
paresis 4
shoulder pain 4
abnormal gait 4
Spots 4
respiratory distress 4
muscle cramps 4
nasal congestion 4
joint stiffness 3
ataxia 3
wheezing 3
acidity 3
agitation 3
apathy 3
groin pain 3
myoclonus 3
lassitude 3
chronic cough 3
Flare 3
vertigo 3
syncope 3
dental pain 3
spasticity 3
sore throat 2
jaw pain 2
Neurologic symptoms 2
pleuritic chest pain 2
limb pain 2
rigors 2
spasm 2
rhinorrhea 2
decreased appetite 2
anosmia 2
Metastatic bone pain 2
halitosis 1
periorbital edema 1
generalized rash 1
Severe pain 1
chest tightness 1
growing pains 1
dry eye 1
elbow pain 1
hunger 1
hyperemesis gravidarum 1
sciatica 1
functional recovery 1
hypothermia 1
heel pain 1
masculinization 1
forgetfulness 1
Girdle pain 1
eye pain 1
urinary frequency 1
oliguria 1
Bone swelling 1
General symptoms 1
physical symptom 1
carpopedal spasm 1
neck pain 1
orthopnea 1
presyncope 1
exhaustion 1
acute abdomen 1
abdominal cramps 1
rib pain 1
photophobia 1
epigastric distress 1
regurgitation 1
chronic back pain 1
arm pain 1
Gastrointestinal symptoms 1
tenesmus 1
Depressive symptoms 1
overweight 1
musculoskeletal disability 1
generalized pain 1
cyanosis 1
starvation 1
thigh pain 1
Postoperative pain 1
angina 1
Stiffness 1
Flu-like symptoms 1
ENT symptoms 1
lightheadedness 1
enuresis 1
belching 1
right upper quadrant pain 1
testicular pain 1
blurred vision 1
Upper back pain 1
facial pain 1
visual hallucination 1
pelvic pain 1
memory loss 1
more...
Drug
G-CSF 63
CSF 58
Zoledronic acid 52
Zoledronic acid 47
PTH 39
EHDP 38
Clodronate 24
APD 18
Filgrastim 18
Ibandronate 16
Dermatol 14
Aredia 13
Filgrastim 13
Denosumab 13
SrCl2 11
CTX 10
Dial 10
ascorbate 9
Zoladex 8
Zoladex 8
CTX 7
ICI 7
CTX 7
Leaf 6
Adriamycin 6
MRC 6
Salmon calcitonin 5
Lenograstim 5
Gallium nitrate 5
Cerezyme 4
Cerezyme 4
PMPA 4
Quadramet 4
Adefovir dipivoxil 4
Ceredase 4
IL-1ra 3
VCR 3
Prednisone 3
Lenalidomide 3
p75 3
SrCl2 3
Estracyt 3
Bortezomib 3
Estracyt 3
IFN-gamma 3
Rituximab 3
caffeine 3
Docetaxel 3
lysine 3
Tenofovir disoproxil fumarate 3
Alliance 2
Glucagon 2
Taxol 2
Asthma 2
-deoxyadenosine 2
Anakinra 2
Cinacalcet 2
Prednisolone 2
MAP 2
ProstaScint 2
Lanthanum carbonate 2
Gefitinib 2
Skelid 2
Bonefos 2
Ipriflavone 2
Vinorelbine 2
Vindesine 2
Spectrum 2
Nephron 2
Lupron 2
PMEA 2
Fosamax 2
Vindesine 2
MDS 2
Skelid 2
ENT 2
IL-2 2
Imatinib 1
Bavituximab 1
Etidronate disodium 1
Sandostatin 1
DDAVP 1
Liarozole fumarate 1
Opium 1
Isotretinoin 1
lactose 1
Potassium citrate 1
Novantrone 1
Bayer 1
HCG 1
ARA-C 1
DEX 1
Nephron 1
Vicryl 1
Iron dextran 1
Actonel 1
Urokinase 1
Sandostatin 1
Dasatinib 1
2-Methoxyestradiol 1
Gabapentin 1
Carbenoxolone 1
NBT 1
Retinoic Acid 1
DPA 1
Thymopentin 1
Iguratimod 1
DDAVP 1
Bosutinib 1
SMP 1
Stilphostrol 1
ETA 1
Cardiovasc 1
ROC 1
Ketoconazole 1
Tenofovir 1
Vitamin A 1
Eulexin 1
Gastro 1
Cetrorelix 1
Infliximab 1
TTC 1
Luteinizing 1
FLP 1
Tacrolimus 1
Infliximab 1
Alfacalcidol 1
DMSA 1
Teriparatide 1
EE2 1
Encore 1
Retinoic acid 1
VCR 1
Estrogens 1
ADR 1
Aprepitant 1
Deflazacort 1
Anandron 1
EPA 1
Rocaltrol 1
Miacalcin 1
Albumin 1
NOV 1
uPA 1
Histamine 1
Mutagen 1
NAG 1
Risedronate sodium 1
PTC 1
Pyridostigmine bromide 1
Doxycycline 1
Ethylenediamine 1
Stilphostrol 1
Enzyme
alkaline phosphatase 279
prostate-specific antigen 36
lactate dehydrogenase 25
ERK 24
MDP 24
acid phosphatase 23
mitogen-activated protein kinase 23
glucocerebrosidase 19
focal adhesion kinase 8
cathepsin K 8
CD10 6
proteasome 6
prostate-specific membrane antigen 5
aspartate aminotransferase 5
calcineurin 5
protein kinase 5
alanine aminotransferase 4
trypsin 4
creatine kinase 4
ATPase 4
protein kinase C 3
luciferase 3
MEK 3
CaMKII 3
peroxidase 3
elastase 2
monoacylglycerol lipase 2
AST 2
beta-glucosidase 2
BMT 2
beta-glucosidase 2
granzyme B 2
MIP 2
HOA 2
tryptase 2
gamma-glutamyl transpeptidase 2
reverse transcriptase 1
urokinase-type plasminogen activator 1
LMT 1
MAT 1
SMP 1
PARP 1
glutamate dehydrogenase 1
pepsin 1
inositol 3-kinase 1
isopeptidase 1
HDR 1
protein phosphatase 2A 1
caspase-3 1
renin 1
lipase 1
legumain 1
thymidine phosphorylase 1
superoxide dismutase 1
ACE 1
IKK 1
thrombin 1
adenylate cyclase 1
lysozyme 1
ACS 1
FPS 1
tyrosine hydroxylase 1
catalase 1
plasmin 1
phosphoinositide 3-kinase 1
complex I 1
topoisomerase 1
glutamate dehydrogenase 1
ribonucleotide reductase 1
P-glycoprotein 1
MAT 1
TdT 1
ribonucleotide reductase 1
glutamate dehydrogenase 1
topoisomerase 1
DNA methyltransferase 1
carboxypeptidase G2 1
thymidine kinase 1
Compound
Clin 379
calcium 349
Dec 225
phosphate 190
vitamin D 158
phosphorus 99
strontium 74
creatinine 54
sodium 48
aluminum 37
EHDP 33
His 30
acetate 27
nitrogen 27
Pamidronate 27
DNA 24
Vitamin D 19
iron 19
Calcitonin 19
retinoic acid 18
water 15
ALP 14
potassium 13
iodine 13
25-dihydroxycholecalciferol 13
glutamate 12
oxygen 12
TNF 12
glucose 11
CTX 10
Dial 10
Adriamycin 9
carbonate 9
urea 9
Morphine 9
MDA 9
ATP 9
A 42 8
Alendronate 8
phosphoric acid 7
fluorine 7
ICI 7
hydroxide 7
NH2 7
Hemoglobin 6
Androgen 6
Risedronate 6
cAMP 6
Alendronate 6
Mithramycin 6
Optimal 5
sulfate 5
BMD 5
HNO3 5
tin 5
ADR 5
5-FU 5
salt 5
Paclitaxel 5
1,4,7,10-tetraazacyclododecane 5
Voriconazole 5
Estracyt 4
Aminoglutethimide 4
tyrosine 4
AMP 4
DTPA 4
lysine 4
cysteine 4
Estracyt 4
TSH 4
Hydroxyurea 4
cadmium 4
ACTH 4
zinc 4
L-PAM 4
Parenteral 4
DIC 4
L-PAM 4
APAP 4
nitrate 4
A 71 4
ethanol 4
acetic acid 4
MTT 4
methionine 3
ASA 3
CAM 3
chlorine 3
6-12 3
Sodium 3
arginine 3
5-HT 3
Thyroid 3
caffeine 3
tungsten 3
Testosterone 3
Guo 3
Docetaxel 3
Oxycodone 3
copper 3
Prednisone 3
Guo 3
Pac 3
tryptophan 3
Testosterone 3
Nilutamide 3
galactose 3
Tiludronate 3
CAP 3
oxalate 3
silver 3
PAS 3
MEK 3
Glucagon 2
retinol 2
acetone 2
Prednisolone 2
TTS 2
nickel 2
PEG 2
aspartic acid 2
NMDA 2
Congo red 2
L-DOPA 2
Asp 2
PAP 2
aldosterone 2
Cyclosporine 2
aspartic acid 2
Ara-C 2
glutamic acid 2
PGE 2
PAP 2
25-hydroxycholecalciferol 2
THP 2
CIT 2
Progesterone 2
PAP 2
Estrogen 2
Glutamate 2
Tin 2
aspartic acid 2
VP-16 2
THP 2
Methotrexate 2
T11 2
Estrogen 2
Mexiletine 2
aspartic acid 2
cobalt 2
BAP 2
MPA 2
LCR 2
DSS 2
SET 2
MPA 2
Off 2
BCNU 2
noradrenaline 2
Mg2+ 2
more...