Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151825 (bone pain)
 3,118 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypercalcaemia is a rare feature of acute lymphoblastic leukaemia (ALL) in adults, particularly of the T cell type. We report on a 24-year-old patient with T-ALL, who presented with symptoms of hypercalcaemia (vomitus, acute renal failure), bone pain, extensive osteolytic lesions and normal white cell count without circulating blasts. An increased serum tumor necrosis factor (TNF-alpha) concentration of 35 pg/ml was found; it remained elevated at 52 pg/ml four weeks later, after having achieved haematological remission. Serum concentrations of IL-1beta, IL-6 and IL-2 were within the control range. The pathophysiology of hypercalcaemia in malignancy and possible mediators of bone resorption, in particular TNF-alpha, are discussed.
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PMID:Severe hypercalcaemia and extensive osteolytic lesions in an adult patient with T cell acute lymphoblastic leukaemia. 964 32

Data on the effects of IL-2 on 49 subjects with an average CD4+ count of 653 and viral load of 3,000 copies, are detailed for the six-month mark. Patients who received the highest and most frequent doses of IL-2 and had high initial CD4+ counts showed great increases in CD4+ levels. Results for both low- and high-dose groups are presented. There were no statistically significant changes in CD8+ cell counts or viral loads over time. Common side effects included fatigue, muscle pain, joint and bone pain, and sleeping problems. Other less frequent side effects are also detailed. Outside of a clinical trial, these types of side effects may lead to high treatment dropout rates and adherence problems in patients receiving IL-2 therapy.
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PMID:Two years of IL-2 in early HIV disease--fantastic increases in CD4+ cell counts. 1136 77