Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151825 (bone pain)
 3,118 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunoglobulin D multiple myeloma is a rare type of multiple myeloma that usually presents as bone pain, fatigue, or weight loss. We report a case of immunoglobulin D multiple myeloma in a 53-year-old Caucasian male patient with previous medical history of anaplastic oligodendroglioma status post-surgical resection who was evaluated for back pain while mowing the lawn. His physical examination showed tenderness over the lower thoracic vertebrae with no sensory or motor impairment. Initial lab investigations showed normocytic anemia and hypercalcemia with low parathyroid hormone. Magnetic resonance imaging of thoracic spine with and without contrast showed acute pathological fracture of the T12 vertebral body with enhancing soft tissue which extended into the left ventral epidural space and left T11-T12 neural foramen. Serum protein electrophoresis showed abnormal protein band in the gamma globulin. Free light chain assay showed serum free kappa which was elevated at 3,090.0 mg/L (reference range 3.3-19.4 mg/L). Immunoglobulin D was elevated at 566.0 mg/dL (reference range <15.3 mg/dL). The patient was successfully treated with standard chemotherapy and autologous peripheral blood stem cell transplant with complete remission 3 years after starting treatment. Advancement in the treatment of immunoglobulin D multiple myeloma urge clinicians to offer their patients new treatment options especially as of the earlier presentation of this subtype of multiple myeloma and the previous reports of worse prognosis.
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PMID:Immunoglobulin D Multiple Myeloma Presenting as Spontaneous Fracture. 2851 9

The study involved a 54-year old female patient admitted with severe renal failure. She had a 1-month history of progressive stage II dyspnoea associated with chest pain, bone pain and anuria. Clinical examination showed hypertension (160/80mmHg), glomerular disease (urinary protein excretion 2+, blood 2+ and diuresis 300 cc). Pleuropulmonary examination showed diffuse bilateral lower-chest crackling sounds. Laboratory tests objectified severe renal failure with creatinine level 107mg, urea 1.65g/l, hyperkalaemia 7.8 mmol/l, CRP value 78mg/l, normochromic normocytic anemia with hemoglobin concentration 5.7g/dl and leukocytosis 13570 without thrombocytopenia, hyperprotidemia 144g/l, normal serum albumin concentration 33g/l, hypercalcemia 116mg/l and hyperphosphataemia 120mg/l. Serum protein electrophoresis showed monoclonal gamma globulin peak 60 g/l. Immunoelectrophoresis of plasma proteins showed IgG kappa gammapathy. Bence-Jones protein urine test was negative. Myelogram showed plasmocytosis 10%. Profile skull x-rays objectified multiple pre-existing geodes. The patient underwent CDT1 protocol with dexamethazone thalidomide 100 mg and oral endoxan.
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PMID:[Renal failure revealing multiple myeloma with preexisting lesions on radiological images]. 3106 21