Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151814 (coronary occlusion)
 3,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. D-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.
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PMID:The anti-arrhythmic effect of D-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism. 834 85

Features of the extrasystolic and postextrasystolic contractility of myocardium isolated from rats aged 4 months (group I, n = 30) and 12 months (group II, n = 30) after postinfarction remodeling of the heart (PIRH) and long-term treatment with carvedilol have been studied. Each age group included in 10 intact control animals, 10 animals with postinfarction cardiosclerosis (PICS), and 10 rats with PICS treated with carvedilol (2.1 mg/kg) during 28 days, beginning with the 45th day after coronary occlusion. The isometric contractility of myocardium was monitored at an electric stimulation frequency of 0.5 Hz. The extrasystolic effect was produced by an electric pulse applied within 0.2 - 5 s interval after the basic stimulation. It is established that the inotropic response of myocardium to the extrasystolic impulse exhibits age-dependent features both the intact rats and in the rats with PICS. The differences can be related to the age-dependent involvement of the ion-transport systems of sarcolemma and sarcoplasmic reticulum into the modulation of excitation--contractility coupling during PIRH. The long-term treatment with carvedilol led to restoration of the Ca(2+)-accumulation reserve of sarcoplasmic reticulum to the age-normal level in young animalsand decreased the risk of development of hemodynamically significant heart rate disturbances in old rats.
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PMID:[Effect of nonselective beta-adrenoblocker carvedilol on extrasystolic and postextrasystolic contractility in the rat myocardium after experimental infarction]. 2036 95

We studied the dependence of post-rest positive inotropic response of isolated rat papillary muscles subjected to rhythmic stimulation on severity of postinfarction cardiosclerosis developed during 6 weeks after occlusion of the left descending coronary artery. The isolated papillary muscles were perfused with oxygenated Krebs-Henseleit solution and electrically stimulated at a rate of 0.5 Hz. In all rats, coronary occlusion provoked postinfarction cardiosclerosis with the formation of a scar occupying 20-50% (min-max of the sample) of the left ventricular wall. Despite the presence of large postinfarction scar in all rats, the positive post-rest inotropic responses greatly varied. The post-rest response in rats with scar occupying <37% left ventricular wall was similar to that in intact animals, but rats with scar area >44% demonstrated dramatically decreased inotropic response to rest periods.
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PMID:Rhythmoinotropic Response of Papillary Muscles in Rats with Different Severity of Postinfarction Cardiosclerosis. 2894 48