Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activity of the pituitary hormones (ACTH, STH, TTH, FSH, LH), the adrenal hormones (cortisol, aldosterone), the kidney hormone (renin), and the thyroid hormones (thyroxine tri-iodthyronine), the thyroxine binding capacity of blood proteins and the activity of the hormones of the pancreas (insulin) and the sex glands (testosterone, estradiol) were studied in 26 males suffering from ischemic heart disease verified by means of selective coronarography and in 20 healthy males with no atherosclerosis of the coronary arteries of the heart. Patients with ischemic heart disease were found to be marked by increased activity in the blood of ACTH, TTH, cortisol, aldosterone, insulin, and estradiol and reduced concentration of STH, thyroxine, and testosterone. These shifts in the activity of the hypothalamo-hypophyseal system and in its subordinate hormonal systems play an important role in the origin of the atherosclerotic process and assosiated ischemic heart disease.
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PMID:[Hormones in ischemic heart disease with the presence of coronary atherosclerosis]. 73 79

Cardiac pains related to estrogen therapy for prostatic cancer (PC) emerged in 53% of treated patients with ischemic heart disease (IHD). The pain complaints were associated with impairment of coronary circulation in 48% of cases. This clinical condition is attributed to elevated STH levels and a trend to hypercorticism. In hypertensive PC patients estrogens provoked more frequent and severe headaches which occurred at initial stages of the treatment in 23% and after 1-year administration of hormones in 44% of patients. Hypertensive reactions may be caused by aldosterone and prolactin hyperproduction. Observation of the therapist and endocrinologist can help to prevent complications in IHD patients with PC.
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PMID:[Changes in hormonal homeostasis and development of disorders of the cardiovascular system in patients with prostatic cancer on estrogen therapy]. 172 22

To evaluate pathogenetic link of ischemic heart dysfunction with the level of endogenic STH in myocardial infarction (MI) patients at different MI stages and to specify prognostic value of STH for MI outcomes, we examined 78 males on MI day 21-26, month 3-6 and a year later. 20 healthy males served control and 17 patients with ischemic heart diseases without MI according to coronaroventriculography (CVG) were a comparison group. STH was measured in all the patients with radioimmunoassay, CVG was made according to M. Judkins. We found that in patients with high level of endogenic STH (> 1 nm/l) within the first postmyocardial infarction month development of reparative and adaptive fibrosis continues 3 to 6 months and is more favorable. If STH physiological level maintains, myocardial contractility remains satisfactory for a long period. In high STH levels, patients with myocardial ischemia more frequently exhibit ventricular arrhythmia. Low STH blood levels lead to left ventricular dilatation, deterioration of cardiac contractility, stenotic coronary atherosclerosis, intracardiac hemodynamics and IHD clinical course. Lethal outcomes occur more frequently.
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PMID:[Correlation of somatotropic hormone with post-infarction myocardial remodelling and clinical prognosis in patients with myocardial infarction]. 1141 83