Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Holter ECG monitoring is a valuable diagnostic technique in both cardiac arrhythmias and ischemic heart disease, known for over 30 years. Current methods of ST segment analyses require the use of computers. Myocardial ischemia is diagnosed if ST segment deviation from isoelectric axis is at least 1 mm, duration of this change is at least 1 minute, and interval is at least 1 minute. There are four ways to measure ST segment deviation from isoelectric axis: measurement of "area of given surface", mean length of ST segment, measurement of the real time of ST segment duration, and optic technique. Use of appropriate leads system is always necessary.
Pol Tyg Lek
PMID:[Evaluation of the ST segment in ambulatory ECG monitoring with the Holter technique]. 841 52

The frequence of ischemic heart disease occurring increases 2-3 fold in postmenopausal period. It is a result of serum lipid profile changes. Estrogenotherapy restores correct lipid relations and protect coronary vessels in this way, preventing stenocardia and cardiac infarcts. Divergent opinions coexist with including progestogens to estrogen replacement therapy. However a view that well selected doses and kind of hormone effectively enhance serum HDL level, begins to prevail.
Ginekol Pol 1995 Feb
PMID:[Contemporary views on estrogen replacement therapy. II. Hormonal therapy in women with imminent ischemic heart disease]. 857 83

Oral propafenone hydrochloride effect was studied on atrial signal-averaged ECG (ASAECG) during time- and frequency-domain analysis in patients with paroxysmal atrial fibrillation (PAF) during ischemic heart disease (IHD). The study comprised 26 patients (15 female and 11 male) mean age 60.8 +/- 6.2. The dose of oral propafenone was 450 mg/day for all days. Recording of ASAECG and 24-hours Holter monitoring were made at baseline, after 10 days and after 6 weeks of propafenone therapy. Time-domain parameters were calculated for ASAECG: the root mean square voltage of the signals in the last 10, 20, 30 ms of the filtered P-wave (RMS 10, 20, 30) and total time duration of filtered P-wave (PWD) and time duration of P-wave for Frank leads X, Y, Z (XP, YP, ZP). During frequency-domain analysis of the terminal part of P-wave the following parameters were calculated in range from 40 Hz to 400 Hz: energy spectrum > -60 dB (A) and decibel drop at 4 Hz (Dd) in logarithmic scale and area ratio 20-50/0-20 Hz (Ar), magnitude ratio (MR1-7) in linear scale for a vector magnitude. Supraventricular arrhythmias were estimated quantitatively and qualitatively by Holter monitoring. The following parameters were estimated in a case of PAF recording: time of manifestation, duration, number of PAF episodes per day, mean heart rate during PAF and subjective symptoms. Moreover, comparable analysis of the following parameters: dimension of left atrial, age, sex, time duration of IHD and PAF and wall motion disturbances--hypokinesis and also left ventricular ejection fraction, mitral regurgitation was done between patients with effective and no effective of antiarrhythmic therapy. Our observation have indicated that oral propafenone therapy does not influence any statistically significant differences all time- and frequency-domain parameters of ASAECG in patients with PAF during IHD. Moreover, comparable analysis of above mentioned parameters has not showed statistically significant differences between examined patients with effective and lack of effective propafenone therapy.
Pol Arch Med Wewn 1995 Aug
PMID:[Effect of propafenone hydrochloride on atrial signal-averaged ECG in patients with paroxysmal atrial fibrillation]. 859 48

Hypertensive crisis is defined as an acute elevation of the blood pressure involving the risk of life. Agents used to the treatment of hypertensive emergencies should lower the blood pressure under control and produce minimal adverse effect. The aim of this study was to evaluate the antihypertensive efficacy of urapidil i.v. in hypertensive emergencies. Twenty three patients (pts) with the hypertensive crisis in association with ischaemic heart disease and/or acute left ventricular failure were studied. Urapidil was given intravenously in the emergent treatment to the group of 23 pts in the mean dose of 50 mg. Systolic (RRs) diastolic blood pressure (RRd) and heart rate were measured within 4 hours after the drug administration. In this group of pts the significant decrease in RRs and RRd after 2 min. of administration of urapidil was observed and the maximum effect (p < 0.05) occurred within 40 min. The heart rate decreased by 8% and was significantly different (p < 0 > 05) at the maximum point of the drug action. Urapidil administered in 25-75 mg i.v. appeared an effective antihypertensive agent in more than 90% of patients with hypertensive emergencies. What was striking, no reflex tachycardia was observed after i.v. administration of urapidil despite its antihypertensive action.
Pol Arch Med Wewn 1995 Dec
PMID:[Evaluation of the antihypertensive efficacy of urapidil in the treatment of hypertension emergencies]. 861 14

The aim of study was to assess the value of signal averaged ecg for detection of patients (pts) at risk for paroxysmal atrial fibrillation (paf). We examined three groups of pts: group I-41 pts with nonvalvular paf, group II-20 pts with hypertension and/or ischemic heart disease without paf and group 3-26 health persons, without organic heart disease. In all pts the signal-averaged electrocardiogram triggered by P waves was recorded. Seven parameters of the spatial magnitude of filtered P wave were measured. Significant difference between group I and group II or III was found in most parameters. Using the method of multidimensional variance analysis we constructed "the diagnostic vector" in multidimensional parameters space, which was used to determine patients belonging to group. Total percent of right decision was 85%. These findings suggest that pts at risk for paf could be detected while in sinus rhythm by using the P wave-triggered signal-averaged ecg.
Pol Tyg Lek 1995 Oct
PMID:[P-wave ekg averaging technique--a new method of selecting patients with paroxysmal atrial fibrillation]. 865 57

The aim of this study was to assess the influence of sotalol hydrochloride on time- and frequency-domain parameters of signal-averaged electrocardiogram (SAECG) in patients with ischemic heart disease (IHD). The study population consisted of 25 patients (16 women and 9 men), mean age 56.6 +/- 8.3. Sotalol was orally used in dose 160 mg/day during 6 weeks. Recording of SAECG and ambulatory Holter monitoring were made at baseline and in 10 day and after 6 weeks of therapy. The following time-domain parameters were analyzed: the root mean square voltage of the last 40 and 50ms of the filtered QRS (RMS 40 i RMS 50), total time duration of filtered QRS (t-QRS) and duration of low amplitude signals < 40 microV in the terminal part of QRS (LPD). Late potentials (LP) were recognized when at least two from three criteria were fulfilled: 1) RMS40 < 20 microV, 2) t-QRS > 114 ms, 3) LPD > 38ms. Frequency analysis of SAECG allowed to calculate the following parameters in logarithmic scale: energy spectrum > -60dB (A) and decibel drop at 40 Hz (Dd) and also in linear scale: area ratio 20-50/0-20 Hz (Ar) and magnitude ratio (MR1-7). The values of RMS40 and RMS50 and also t-QRS and LPD did not significantly change after sotalol treatment. At baseline the presence of LP was recorded in 7 (28%) cases, after 10 days of antiarrhythmic therapy only in 3 (12%), and after 6 weeks occurred in 6 (24%) cases. Moreover, sotalol hydrochloride did not statistically significant change frequency-domain parameters in logarithmic scale: A and Dd. On the other hand, the parameters in linear scale: MR1, MR4 and MR6 significantly change but these changes were not uniform. These findings suggest that oral treatment of sotalol hydrochloride did not significantly change time- and frequency-domain parameters of signal-averaged electrocardiogram in patients with ischemic heart disease.
Pol Arch Med Wewn 1996 Apr
PMID:[The effects of long-term treatment of sotalol hydrochloride on time and frequency domain parameters of signal averaged electrocardiogram in patients with ischemic heart disease]. 875 34

A 24-hour ECG monitoring was carried out in 130 patients with stable exercise angina pectoris and history of myocardial infarction. A diagnosis of ischemic heart disease was based on anamnesis, positive result of exercise test and dipyridamole test, and the result of coronary angiography in some patients. Patients with unchanged repolarization period in ECG were classified to the study. Electrocardiogram was registered with Holter technique in patients performing their usual activities. Recorded ECG was analysed with visual technique in Medilog 3000 system. Two hundred thirty seven ischemic episodes were shown in the examined patients, including 69% of painless ischemic attacks and 31% of ischemic attacks with anginal pain. Duration of painless ischemic attacks with anginal pain. Duration of painless ischemic attacks was longer, heart rate slower, and ST segment elevation did not differ in both types of myocardial ischemia.
Pol Tyg Lek 1996 Mar
PMID:[Incidence of painless ischemic heart disease]. 892 45

The aim of this study was evaluation of intravenous propafenone hydrochloride effects on maintenance of atrial signal-averaged ECG (ASAECG) during time-domain and frequency-domain analyses in patients paroxysmal atrial fibrillation (PAF) accompanying ischemic heart disease (IHD). The study population of 20 patients included 12 women and 8 men (mean age 58.8 +/- 8.9). For ASAECG were calculated time-domain parameters: the root mean square voltage of the signals in the last 10, 20, 30 ms of the filtered P-wave (RMS 10, 20, 30) and duration of filtered P-wave (PWD). During frequency-domain analysis of the terminal part of P-wave the following parameters were calculated in the range from 40 Hz to 400 Hz: energy spectrum > -60 dB (A, YA) and decibel drop at 40 Hz (Dd, YDd) in logarithmic scale and area ratio 20-50/0-20 Hz (Ar, YAr), peak (P1-7, YP1-7), magnitude ratio (MR1-7, YMP1-7) in linear scale for a vector magnitude and Frank lead Y. Time-domain analysis of ASAECG did not show any significant changes--RMS10 increased from 5.2 +/- 2.5 microV to 5.9 +/- 2.6 microV, RMS20 from 6.9 +/- 3.4 microV to 7.3 +/- 2.5 microV and RMS30 from 8.4 +/- 3.1 microV to 8.5 +/- 2.2 microV after propafenone. Duration of filtered P-wave (PWD) increased from 125.1 +/- 21.9 ms to 128.4 +/- 22.7 ms (p > 0.05). During frequency-domain analysis both in linear and logarithmic scales no any significant differences after administration of propafenone were noted. The obtained results have indicated that intravenous propafenone hydrochloride did not change significantly time-domain and frequency-domain parameters of ASAECG in patients with PAF during IHD.
Pol Tyg Lek 1996 Mar
PMID:[Effect of intravenous propafenone on maintenance of atrial signal-averaged ECG in patients with paroxysmal atrial fibrillation]. 892 47

Aims of the study were to assess the usefulness of global and segmental myocardial contractility parameters detected during dipyridamole echocardiography test in diagnosis of ischaemic heart disease. Dipyridamole time (the time from the onset of dipyridamole infusion to development of asynergy) was also evaluated. The study included 97 patients with suspected or known ischaemic heart disease (32 patients after acute myocardial infarction), mean age 48.5 years. All patients underwent dipyridamole stress echocardiography and afterwards coronary angiography. Significant stenosis (< or = 70% lumen reduction in at least one major coronary vessel) was present in 52 (54%) patients-group I. Normal coronary arteries or no significant stenosis were found in 45 (46%) patients-group II. Significant increase of wall motion score index was observed in group I. No significant change with two and there vessels disease have shorter dipyridamole time than patients with one vessel disease. Significant decrease in ejection fraction during dipyridamole echocardiography test was found in group I, whereas not significant increase in ejection fraction was observed in group II. Dipyridamole echocardiography test is a sensitive, specific and well tolerated test in the diagnosis of ischaemic heart disease.
Pol Arch Med Wewn 1996 Sep
PMID:[Echocardiographic analysis of segmental and global myocardial contractility after administration of dipyridamole in patients with ischemic heart disease]. 912 16

Over 30 years of follow up from the Framingham Study an association between serum cholesterol concentration and ischemic heart disease is still analyzed. Critical evaluation shows that a decrease of cholesterol concentration cause a decrease of ischemic heart disease prevalence.
Pol Merkur Lekarski 1996 Sep
PMID:[Treatment of hypercholesterolemia--the other side of the coin]. 913 93


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