Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Japanese Guidelines for the Management of Hypertension (JSH2000) have been published in June, 2000, which basically followed the direction of 1999 WHO/ISH and JNC-VI guidelines. Target blood pressures for young or middle-aged hypertensive patients or hypertensives with diabetes are recommended to maintain less than 130/85 mmHg. In contrast, blood pressure control for hypertension in elderly is set taking the subject's age into consideration with systolic blood pressure lower than 140-160 mmHg and diastolic below 90 mmHg. Among hypertensive cardiovascular diseases, stroke is more common while ischemic heart disease is less common in Japanese than in Caucasians. Frequency of hypertension in Japan, which is estimated to be one-fourth of whole population and two-thirds of persons aged 60 years or over, has been declined in recent years, because of increasing treatment of hypertension, resulting in a decrease in stroke mortality and morbidity. However, the number of persons with hypertension controlled to below 140/90 mmHg seems to be about 20 percent of all hypertensives. Therefore, increases in rates of awareness, treatment and appropriate control of hypertension are the important issue for the management of hypertension in Japanese at present state.
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PMID:[Management of hypertension in Japan--current state and clinical issue]. 1139 88

The purpose of this study was to determine the relationship between hypertension and onset of cardiovascular disease in Japan. As part of an ongoing epidemiological survey of cardiovascular diseases in Hokkaido, Japan, 1,798 subjects (806 males and 992 females; mean age in the initial year of the survey, 58.6+/-11.8 years) were selected, after excluding subjects who had been taking antihypertensive drugs, from a total of 2,136 subjects who had undergone medical examinations in 1991 in the town of Tanno and in 1992 in the town of Sobetsu, two rural communities in Hokkaido. Height, weight, casual systolic and diastolic blood pressures in the sitting position and blood biochemical values of all subjects were measured, and the subjects were divided into blood pressure level groups according to the 1999 World Health Organization/International Society of Hypertension (WHO/ISH) criteria. The follow-up survey was concluded at the end of August in 1999. The endpoints in this study were onset of circulatory disease or death due to circulatory disease. During the follow-up period, circulatory diseases (ischemic heart disease or stroke) occurred in 94 of the subjects. The incidence rates of cardiovascular disease (per 1,000 persons/year) for subjects divided into blood pressure groups according to the 1999 WHO/ISH blood pressure classification were 6.24 for the optimal+normal blood pressure level group, 11.26 for the normal high blood pressure level group, and 15.83 for the grade 1-3 hypertension group. Thus, the incidence rate of circulatory disease increased as the blood pressure level increased, and there was a significant difference between the incidence rate in subjects in the grade 1-3 hypertension group and the incidence rate in subjects in the optimal+normal blood pressure level group (p<0.05). In a Cox's proportional hazards model with onset of circulatory disease as the endpoint, diastolic blood pressure was shown to be an independent risk factor with a relative risk of 1.01. The results suggest that hypertension is an independent risk factor for onset of circulatory disease.
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PMID:Influence of hypertension on the incidence of cardiovascular disease in two rural communities in Japan: the Tanno-Sobetsu [corrected] study. 1791 14

The present study aims at comparing the prescribing pattern of antihypertensive drugs in essential hypertension with specific co-morbid conditions with JNC-VII and WHO-ISH guidelines. Adult patients of both sex, who were attending medicine OPD of Shri Krishna Hospital, Karamsad, Gujarat since last 6 months and being prescribed antihypertensive drug/s for hypertension, were selected for the study. Hypertensive patients with co-morbities diabetes mellitus, ischemic heart diseases, congestive heart failure, and chronic renal diseases were included in the study. Adherence to JNC-VII guideline and WHO-ISH guidelines with respect to prescribing antihypertensive drugs in patients with diabetes mellitus were found to be 97% and 40.81% respectively, while it was found to be 72.27% to both the guidelines in patients with IHD. Similarly in cases of hypertension with CHF, adherence to prescribing antihypertensive were found to be 93.62% and 38.30% respectively, whereas for CKD patients, adherence to both guidelines was found to be same i.e. 33.33%. There is need of following such authentic guidelines in managing hypertension like chronic disease since these guidelines are based on various clinical trials and successful attainment of target BP in patients will be much easier by implementing them.
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PMID:Adherence To JNC-VII and WHO-ISH guidelines of antihypertensive medications prescribed to hypertensive patients with co-morbid conditions. 2657 84

Cardiovascular diseases (CVD) continue to be the leading cause of death and disability worldwide, representing 30% of all death. In Georgia 36% of all death caused by ischemic heart disease and 23% caused by stroke. There is a limited data on association between socioeconomic status (SES) and CVD risk in Georgia. Our study aims at assessing association between SES and CVD risk factors in a cohort of adult Georgians. A cross-sectional study was conducted in the region of Western Georgia between June 2007 - June 2008. 1196 individuals aged 40-70 years were enrolled in the study. To assess SES we collected information about education, income, ownership of a private transport, and employment. CVD risk was assessed by the WHO/ISH risk classification scale. In addition, anthropometric measurements were conducted in each study participant. Low education level (adjusted odds ratio (aOR) 2.85; 95% confidence interval (CI), 1.57-5.17), obesity (aOR 2.13, 95% CI 1.16 -3.92) and abdominal obesity (aOR 2.21, 95% CI 1.26 -3.87) were statically significantly associated with more than 10% 10 year risk of a fatal or non-fatal cardiovascular event. Lower education level (not finished high school -aOR 2.21 95% CI 1.44 - 3.38, undergraduate - aOR 1.52, 95% CI 1.12 - 2,05), income 120 USD or more (aOR 0.73, 95% CI 0.54 -1.00), overweight (aOR 1.68, 95% CI 1.07 - 2.63), obesity (aOR 1.58, 95% CI 1.04 - 2.41), and abdominal obesity (aOR 1.43, 95% CI 1.01 - 2.03) were found to be statistically significant predictors of CVD in our study population. We found that education level, income, body mass index and waist to hip ratio are CVD risk factors. Public health authorities, as well as clinicians should consider this finding in primary and secondary prevention and organize multidisciplinary teams to address those risk factors.
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PMID:IMPACT OF SOCIOECONOMIC STATUS ON CARDIOVASCULAR RISK IN GEORGIAN POPULATION. 3020 98