Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Men drafted into the Army, hospitalized during 1944 to 1945 for service-connected trauma to the extremities, and consequently separated for disability were followed for mortality from January 1946 to April 1977. Three groups were established consisting of those whose injury resulted in (a) limb amputation, (b) disfiguration without loss of body part, (c) loss of part of hand or part of foot. Group (a) had a mortality, standardized for age and calendar time, 1.4 times that of Group (b), matched on age and length of service at admission, and 1.3 times that of Group (c), similar on age and length of service to Group (a). The excess mortality of limb amputees was statistically significant (P less than .05) for ischemic heart disease, other diseases of the cardiovascular system, suicide by poisoning, alcholic cirrhosis, and cute pancreatitis. Possibly (P less than .1) there was also an increased risk of diabetes and cancer of the buccal cavity and pharynx.
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PMID:Report to the Veterans' Administration Department of Medicine and Surgery on service-connected traumatic limb amputations and subsequent mortality from cardiovascular disease and other causes of death. 39 10

A clinico-pathologico-anatomical analysis of 150 cases of sudden death in a district of Bohemia in the period 1971--1973 revealed coronary atherosclerosis as the most frequent cause of sudden death(87.3%); stenosing coronary atherosclerosis without postmortally detectable myocardial necrosis participated by 71.7% in the coronary group. Men, especially in younger age groups, were more frequent victims than women. Within one-hour duration of the terminal episode, 57.3% of the deaths occurred; 45.3% of the decreased succumbed to sudden death at their homes. With advancing age, severe findings in the coronary vascular bed and in the myocardium became more frequent. One half of the victims of sudden death in the coronary group had histories of ischaemic heart disease; 37 suddenly deceased persons (28.2%) had experienced myocardial infarction. In another 25 victims of sudden death scars after formerly asymptomatic myocardial infarcts were found.
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PMID:Analysis of sudden deaths in a district of Bohemia in the period 1971--1973. 59

ADP-induced platelet aggregation in vitro has been studied in 90 normal controls and in 30 patients with ischemic heart disease (IHD) and 22 with peripheral thromboatherosclerosis (PTA). The sensitivity to ADP was defined by the threshold concentration which produced secondary aggregation with an amplitude corresponding to not less than 80% of the transmission obtained by platelet-poor plasma. In the normal controls the threshold concentration was significantly lower in women aged 50 or more than in women under that age. The geometric means were lower in the patients than in the controls. Significantly lower threshold concentrations than in the corresponding age groups of controls were found in the following age groups of patients: Men and women greater than or equal to 50 years with IHD (p less than 0.005 and p less than 0.001, respectively), men and women under 50 with IHD (p less than 0.05). Men and women greater than or equal to 50 years with PTA (p less than 0.002 and p less than 0.01, respectively), men and women under 50 with PTA (p less than 0.005).
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PMID:ADP-induced platelet aggregation in vitro in patients with ischemic heart disease and peripheral thromboatherosclerosis. 87 5

Deaths from ischemic heart disease(IHD) occurring during a period of one year in Helsinki in persons aged 65 years or younger have been investigated by the Ischaemic Heart Disease Register. Altogether 526 fatalities were registered. Autopsy data were collected in 432 cases, the autopsy rate being 82 percent. The results are presented separately for persons autopsied in the pathologic departments, representing mostly delayed deaths in hospitals, and for medico-legally autopsied persons representing sudden deaths outside hospitals. The diagnosis of IHD death was either based on the positive patho-anatomic or clinical evidence of an acute heart attack or supported by a history of clinical IHD in 92 percent of all registered fatal cases. In the remaining fatalities the possibility of other causes of death had been more or less definitely excluced. All persons with an acute attack of IHD and all autopsied cases showed a division into four socio-economic groups very similar to that of the population of Helsinki. Men belonging to the lowest social group were over-represented among medico-legally autopsied cases. A history of a previous heart disease, visits to a doctor and the use of digitalis were less common in persons autopsied medico-legally than in those autopsied in the pathologic departments. In the former an acute infarction was most often located in the posterior wall and in the latter in the anterior wall of the left ventricle. The prevalence of an occlusion was highest in the right coronary artery in the former and in the left anterior descending coronary artery in the latter; In medico-legally autopsied cases in which a recent myocardial infarction was observed the interventricular septum was involved in 81 percent, but in cases with an old infarction the septum was involved in only 52 percent. No difference in the size of the hearts, the frequency of an old infarction or the prevalence of coronary occlusions was found between persons autopsied in the pathologic and forensic departments. Although a previous angina was about equally common in both sexes, old infarctions were more common in men. The increase in heart weight had occurred proportionally to the same extent in both sexes.
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PMID:Deaths from ischemic heart disease in persons aged 65 or younger in Helsinki in 1970 with special reference to patho-anatomic findings in hearts.?211. 112 61

In the Tecumseh study population examined from 1967 through 1969, 1457 men and 1607 women were separated into young (20-39 years), middle (40-54 years), and old (past 55 years) age categories. A subset of the study population, 183 men and 200 women who were repeatedly hyperglycemic according to a modified glucose tolerance test, were divided into the same age groups. Means and standard deviations of adiposity index, serum cholesterol, serum triglyceride, blood glucose, and systolic blood pressure were calculated for the total population and hyperglycemics. Correlation coefficients were determined for the relationship between adiposity index and each of the other variables and between paired variables exclusive adiposity index. Correlation coefficients for the latter relationships were recalculated after adjustment for the effect of adiposity. Means of variables were higher in middle and older age categories than in young age categories in both sexes, but the greatest incremental increases occurred between the young and middle-aged groups of men and between middle and old age groups among women. Men had significantly higher mean triglyceride and systolic blood pressure values than women in young and middle ages. Except for the cholesterol-triglyceride association, lipids, glucose, and systolic blood pressure were more highly correlated with adiposity than with each other. Correlations between variables were reduced by adjustment for adiposity. Hyperglycemics had higher mean adiposity indexes, serum lipids, and systolic blood pressures and generally higher correlations of variables than the entire study population. Much of the interrelationship of variables among hyperglycemics was associated with adiposity. Among men, higher mean triglyceride and systolic blood pressure levels, more frequent coexistence of risk factors, and a tendency to have large incremental increases in mean variables between young and middle age probably contribute to greater male susceptibility to ischemic heart disease. Levels of variables in the population and aggregation of coronary precursors in individuals are related to adiposity and hyperglycemia.
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PMID:Coronary risk factors in a community. Findings in Tecumseh, Michigan. 124 37

In a cohort of 3383 men aged 53 to 74 in the Copenhagen Male Study we investigated the association between ischaemic heart disease (IHD) and the Lewis blood group, assigned to chromosome 19. Among men with the Le(a-b-) phenotype, 8% had a history of non-fatal myocardial infarction, among others the frequency was 4%. The corresponding odds ratio was (95% confidence interval: CI) 1.9 (1.2-3.0) P < 0.01, men with Le(a-b-) had a risk-factor profile and pattern of disease resembling that of Reaven's syndrome X. In a subsequent prospective study 343 men with arteriosclerotic stigmas were excluded. The men had their morbidity and mortality recorded over the next 4 years. One-hundred-and-one men suffered IHD; 26 dying from IHD. In total 162 men died. Men with Le(a-b-) had an increased risk of death from IHD compared with others. Adjusted for age, relative risk (RR) (95% CI) was: 4.4 (1.9-10.3), P < 0.001, and for all causes of mortality: RR = 1.6 (1.0-2.6), P < 0.05. Men with the Le(a-b-) phenotype had an increased risk of an IHD event compared to men with other phenotypes (RR = 1.6 (0.9-2.8), P = 0.10) and a significantly higher IHD case fatality rate (RR = 2.8 (1.5-5.2), P = 0.01). The finding that the Le(a-b-) phenotype is a genetic marker of IHD risk may have implications in terms of prevention. The Le(a-b-) phenotype may also contribute to providing an explanation for the substantial ethnic differences found in the incidence of IHD. The similar risk-factor profile and pattern of disease found between Le(a-b-) men and individuals with Reaven's syndrome X is hypothesized to be due to a close genetic relationship on chromosome 19.
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PMID:The Lewis blood group--a new genetic marker of ischaemic heart disease. 147 47

The purpose of the study is to analyse the evolution of sex differentials in mortality rates in Catalonia (Spain), to assess which causes of death have the higher differentials and to compare the results with other countries. Standardized mortality rates (direct method), sex mortality ratios and differences were obtained. Mortality data refers to 1985 to allow for comparison. Men had higher mortality than women, for cancer, accidents and diseases of the digestive tract. Women had higher mortality rates for endocrine diseases, mental disorders, cardiovascular, skin and muscle-skeleton diseases and ill-defined causes. The evolution in recent years shows a relative stabilization after an increasing trend observed from 1960 to 1979. In general, men had a 60% higher than women age-adjusted mortality rates in the four countries to which Catalonia is compared. Suicide and accidents showed the highest sex mortality ratios. Diabetes showed a different ratio in Catalonia and Spain (higher female mortality rate) compared to other countries. The causes of death with higher male mortality were accidents, as well as causes associated with smoking (lung cancer and ischemic heart disease).
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PMID:[Differential mortality by sex in Catalonia]. 151 32

We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atherosclerosis was assessed with high-resolution B-mode ultrasonography. Men with a casual sitting systolic blood pressure of 175 mmHg or more had a 3.17-fold (95% confidence interval 1.79-5.61) prevalence of intima-media thickening--adjusted for age, smoking, S-LDL-cholesterol, IHD history and diabetes--compared to men with lower systolic pressures. The relative prevalence of carotid plaques in men with raised systolic pressures. The relative prevalence of carotid plaques in men with raised systolic blood pressure was 2.61 (95% confidence interval 1.44-4.72) in relation to men with no lesions. Our findings suggest that systolic but not diastolic hypertension is associated with an increased prevalence of both early and advanced atherosclerotic lesions in carotid arteries.
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PMID:Carotid atherosclerosis in relation to systolic and diastolic blood pressure: Kuopio Ischaemic Heart Disease Risk Factor Study. 203

The records of 36 patients (37 eyes) with central retinal artery occlusion (CRAO, 19 patients, 19 eyes), branch retinal artery occlusion (BRAO, 15 patients, 16 eyes), and cilioretinal artery occlusion (CIAO, 2 patients, 2 eyes) were reviewed with respect to underlying systemic disorders. Hypertension was the most common disorder (58%). Half of the patients had cardiovascular disorders including ischemic heart disease, valvular disease, atrial fibrillation, internal carotid artery obstruction, and atrial myxoma. Seventeen percent of the patients had diabetes mellitus, and 8% had hyperlipemia. Cerebral infarction was detected in a quarter of the patients. The incidence of the disease was one CRAO patient per 1,000 outpatients. Age distribution showed a peak in the seventh decade. Men were twice more frequently affected than women. Right eyes were more commonly involved.
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PMID:[Retinal arterial obstruction and systemic disorders]. 204 31

Platelet activity was assessed in a sub-sample of 56 participants in the MRC Diet and Reinfarction Trial (DART). Men whose diets contained a high ratio of polyunsaturated to saturated fatty acids (a P:S ratio of greater than 0.5) showed reduced secondary platelet aggregation to adenosine diphosphate (ADP) in platelet-rich plasma (PRP), and diminished platelet aggregation to ADP in whole blood. A trend of reduced secondary platelet aggregation to ADP with increasing dietary eicosapentaenoic acid was noted, but this was not statistically significant. The results of this study and the MRC Diet and Reinfarction Trial suggest a mediatory role for platelet activity in the relationship between diet and ischaemic heart disease.
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PMID:Long-term diet modification and platelet activity. 204 58


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