Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Screening examination of 12,191 students in their first year of study at medical faculties and technical institutes in Moscow, Kharkov, Alma-Ata and Tashkent showed the following prevalence of major risk factors of ischaemic heart disease among males and females: arterial hypertension: 4.6-17%; 1.2-6.5%; smoking: 20.2-41.0%; 0-3.5%; overweight 6.2-16.9%; 8.1-18.3%; low physical activity: 35.0-67.4%; 40.7-86.4%. Active intervention aimed at preventing the mentioned risk factors, carried out in Kharkov (2 years) and in Alma-Ata (1 year) led to a decrease in the prevalence of arterial hypertension and smoking, and to an increase in the degree of the student's physical activity, but did not have a demonstrable effect on the development of overweight.
Cor Vasa 1988
PMID:Epidemiology and possibility of prevention of ischaemic heart disease risk factors among students in various USSR regions. Programme and first results of All-Union Cooperative Study. 316 80

The growing incidence and importance of cardiovascular diseases in a number of countries calls for systematic quest for most efficient methods of treatment, which besides prevention and drug therapy include also surgical treatment. A group of experts from member countries of the Council for Mutual Economic Assistance (CMEA) has worked out a scientific prognosis of trends of the development of cardiovascular surgery, which include surgical treatment of ischaemic heart disease, congenital and acquired heart defects, renovascular hypertension and affection of the aortic arch. The prognosis includes also an estimate of the number of operations which will have to be performed in the mentioned diseases per 1 million inhabitants of the CMEA member countries.
Cor Vasa 1988
PMID:Scientific prognosis of trends in the development of cardiovascular surgery in the socialist countries. 323 10

The authors compare the prevalence of risk factors of atherosclerosis and ischaemic heart disease (dyslipoproteinaemia, elevated arterial pressure, overweight, smoking, low physical activity) in representative samples of 11- and 14-year old school-children in Moscow, Novosibirsk and Tallin. The number of pupils subjected to medical examination totalled 3369; the respondence rate was 87-92%. There appeared a number of regional differences: the study in Moscow showed the highest prevalence of elevated arterial pressure and overweight, in Novosibirsk - hypertriglyceridaemia, in Tallin - hypercholesterolaemia. The most unfavourable situation was registered in school-children in Novosibirks. The authors conclude that when planning preventive measures among the population it is necessary to take into account regional specificities and differences in the intensity of risk factors in children populations.
Cor Vasa 1988
PMID:Epidemiological characteristics of dyslipoproteinaemia and certain other risk factors of atherosclerosis and ischaemic heart disease in 11- and 14-year children in different climatogeographic zones. Results of a cooperative study. 326 84

The effectiveness of preventive measures in populations subjected to a different degree of preventive activity was according to the dynamics of risk factors (RF) tested in the course of four years. Among 6619 examined men aged 40-59 years, a high incidence of RF (79.2%), their connection with ischaemic heart disease (IHD), and frequent simultaneous incidence of several RF even in subjects without IHD were found. The four-year preventive intervention programme was efficient as regards a decline in the incidence of arterial hypertension (AH) from 24.8% to 19.8%, and smoking from 40.1% to 30.6%, simultaneously with a decrease in the mean level of these RF; these favourable changes did not occur in the control group. Data are analysed concerning the percentage of normalization and the incidence of an elevated BP level, cholesterol and body weight. The study proved the possibility of preventively influencing the incidence of AH in the population, and showed the importance of applying preventive measures in subjects with "borderline" values of RF, such as AH and overweight.
Cor Vasa 1988
PMID:Risk factors dynamics in multifactorial prevention of ischaemic heart disease. 337 44

The immune cytotoxic mechanism of myocardial lesion was studied in 15 patients with non-specific myocarditis (NM) and in 10 patients with idiopathic congestive cardiomyopathy (ICC). In addition, 10 control patients having ischaemic heart disease (IHD) with congestive heart failure (CHF) and a control group of blood donors were examined. The following parameters were examined: anti-heart antibodies (by indirect enzyme-linked immunosorbent assay), lymphocyte sensibilization (by leucocyte migration inhibition test; the antigen used was cardiomyocyte membrane protein), and killer cells (K-cells) activity in the course of antibody-dependent cell-mediated cytotoxicity. Anti-heart antibodies were found in 73% of patients with NM, 50% patients with ICC and 33% patients with CHF. Lymphocyte sensibilization to the myocardium was found in 87% of patients with NM, and in more than half of the patients with ICC. Cardiospecific cytotoxic immune reaction was reproduced in vitro in 9 patients with NM and in 4 patients with ICC. It is assumed that an analogical mechanism of myocardial lesion functions in vivo.
Cor Vasa 1988
PMID:Immune cytotoxic mechanism of myocardial lesion in non-specific myocarditis and idiopathic congestive cardiomyopathy. 339 Oct 36

The study included 43,197 men aged 40-54 years, of whom 23,378 were in the intervention group and 19,819 in the comparison group; the number of man-years of follow-up totalled for the whole group 177,703. The study proved the efficacy of active, predominantly secondary prevention of arterial hypertension (AH), carried out in men aged 40-54 years over a period of 3-5 years in 12 centres within the framework of the cooperative programme. In comparison with the control group, the following changes were registered in the intervention group: 1) overall mortality decreased by 17.3%; 2) stroke mortality decreased by 48.4%; 3) non-lethal stroke morbidity decreased by 51.4%; 4) morbidity of non-fatal myocardial infarction decreased in the course of four years by 23.8%. In contrast to this, mortality due to ischaemic heart disease was in the intervention group and in the control group practically the same.
Cor Vasa 1988
PMID:Medical efficacy of a cooperative prevention programme of arterial hypertension. 339 Oct 41

A comparison is made of two epidemiological studies conducted within an eight-year interval on randomly selected independent samples of male population aged 40-59 years in one of the municipal districts of Moscow. In the years 1975-1977, 3908 men (response rate 77.7%) were examined, in 1983-1984 1662 men (response rate 72.0%). The comparison concentrated on the detection of changes in the incidence of major risk factors of IHD: arterial hypertension, dyslipoproteinaemia, overweight, smoking. Over the period under review, the incidence of hypertension and overweight did not practically change, a statistically significant decrease occurred in the incidence of hypercholesterolaemia and hyperglyceridaemia; the incidence of hypo-alpha-cholesterolaemia did not change. A significant drop (by 10.2%) occurred in cigarette smoking.
Cor Vasa 1987
PMID:Changes in the incidence of ischaemic heart disease (IHD) risk factors among a male population without IHD aged 40-59 years after eight-year period (from 1975-1977 to 1983-1984). 343 44

Pupils of Moscow schools with normal and elevated arterial pressure were followed up over a period of 8 years. The study confirmed the existence of the "tracking" phenomenon in blood pressure. When identifying groups of children requiring constant medical control, it is necessary to take into account both the initial level of arterial pressure and the body mass, arterial pressure values at repeated measurement, and the family history. Elevated arterial pressure (greater than or equal to 140/90 mmHg) was present among boys more frequently than among girls (in twenty-years olds the respective proportions were 16.7 vs. 0.8%). Furthermore, a considerable stability of overweight (40-70%), frequent smoking (among twenty-years olds, nearly 60% of boys and 30% of girls are smokers), and low physical activity in nearly half of the investigated children were found. These results confirm the need for early prevention of the development and for control of risk factors of ischaemic heart disease.
Cor Vasa 1987
PMID:Development of main risk factors of ischaemic heart disease in children and adolescents (eight-year prospective study). 343 45

The influence of digoxin, digitoxin and g-strophanthin (ouabain) on the sinus node function (recovery time, sinoatrial conduction time, PP-interval) and on ventricular repolarisation (corrected QT interval and QT during permanent atrial stimulation) was studied in 101 patients (36 with sick sinus syndrome-SSS, 34 with ischaemic heart disease-IHD, and 31 control patients without cardiac disease). Digoxin caused marked prolongation of sinoatrial conduction time (in SSS and in control patients), digitoxin prolonged the PP interval (in IHD and SSS patients); digitoxin and ouabain shortened the QTcorr in SSS patients, ouabain shortened also QT during atrial pacing. The results do not point to specific indication of individual glycosides in sinus node function disturbances. Under certain clinical prerequisites, however, digitoxin can be recommended in ventricular ectopic contractions caused by prolonged or inhomogeneous repolarisation, and also the capacity of ouabain to shorten the repolarisation time deserves attention.
Cor Vasa 1987
PMID:[Acute electrophysiological effects of cardiac glycosides on sinus node function and ventricular repolarization under clinical conditions]. 343 48

The authors summarize their experience with intraaortic balloon counterpulsation (IABC) at the Institute for Clinical and Experimental Medicine between 1978-1984. A total of 756 cardiac surgery procedures were performed for ischaemic heart disease (IHD), and 266 procedures for rheumatic heart disease (RHD). Of patients operated on for IDH, IABC was used in 38 (5%) and, of those undergoing surgery for RHD, in 38 cases (14%). Overall, IABC was employed in 76 patients, i.e., 7%. Ventricular assistance using IABC was successful in 55% of patients. The technique was significantly more successful in IHD (68%) than in RHD (42%) patients. IABC was less successful in IHD patients suffering myocardial infarction intraoperatively. Moreover, the success of IABC depended on its early initiation. Eleven patients (14%) developed complications associated with IABC. The data do not differ from results reported by world's leading centres.
Cor Vasa 1987
PMID:Intraaortic balloon counterpulsation. 343 49


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