Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper presents the results of a primary medical examination and of a prospective, on the average 14-year follow-up study of the male population of Kaunas aged 45-59 years (n = 2452). The prevalence of overweight, according to the WHO criteria, was 48.7%, that of obesity 20.5%. With increasing body mass index (BMI) there occurred a statistically significant increase of main risk factors of ischaemic heart disease (IHD) and of IHD itself. The results of the prospective study showed a U-shaped relationship between BMI and mortality from all cardiovascular diseases, and a J-shaped relationship between BMI and mortality from IHD and morbidity of acute myocardial infarction, respectively. The same relationship held true even after standardization of the level of all other risk factors using the multiple logistic function. Thus, the overweight was confirmed as an independent IHD risk factor in the given population.
Cor Vasa 1992
PMID:Prognostic value of body mass index in the development of cardiovascular diseases among Kaunas male population. 130 27

One-year open Multicentric Isradipine Study (MIS) performed in 7 centres in Czechoslovakia included 144 patients with mild and moderate hypertension. Isradipine was given at a dose of 2.5 mg daily. If normalization of diastolic blood pressure (BP) had not been reached, the dosage was increased to 5 mg. Monotherapy with isradipine normalized diastolic BP in 44% of patients. Isradipine (5 mg daily) was combined with bopindolol in patients in whom isradipine alone failed to normalize diastolic BP. These had higher mean systolic and diastolic BP, body weight, erythrocyte and platelet counts at the beginning of the study. The combination of isradipine with bopindolol normalized diastolic BP in 87% of the group at the end of 48 weeks' treatment. Tolerance was excellent in 82% of patients. Treatment was discontinued in 8% patients, undesirable effects being the reason in 2%, ineffective therapy in 2% and poor adherence to therapy in 4%. Isradipine in monotherapy or in combination with bopindolol did not exert an adverse effect on the metabolic risk factors of ischaemic heart disease (cholesterol, glycaemia).
Cor Vasa 1992
PMID:MIS (Multicentric Isradipine Study of antihypertensive therapy). 136 24

The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity. Prazosin and nonachlazine in monotherapy reduced the number of anginal attacks and episodes of painless myocardial ischaemia.
Cor Vasa 1991
PMID:The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease. 165 53

The authors compared the results of examination by means of exercise precordial ST mapping and exercise 201-thallium scintigraphy in 43 patients with ischaemic heart disease and in 10 controls. The methods have been found to be equally helpful in establishing the diagnosis of myocardial ischaemia. 201-thallium scintigraphy is preferred when trying to quantify the lesion and to localize it. The currently available techniques of exercise EGG mapping do not always make determination of ischaemia distribution possible. The benefits inherent in either method are their non-invasiveness and good reproducibility, features making them ideal tools for assessing the effect of treatment.
Cor Vasa 1991
PMID:Diagnosis of myocardial ischaemia by means of precordial ST mapping and exercise 201-thallium scintigraphy. 174 20

The purpose of this angiographic study was to make a review of patients with coronary artery ectasia (CAE) and to compare the average coronary artery diameters of proximal, middle and distal segments of the following three groups of coronary arteries: Group E (ectatic segments in patients with CAE and ischaemic heart disease), Group E-n (presumably normal segments in the same group of patients) and Group N (normal coronary arteries of control patients). It was found that distal segments of all three coronary arteries and the middle segment of the circumflex artery in Group E-n were significantly narrower than the corresponding segments in Group N (p = 0.001 or less than 0.05 respectively), which suggested the arteriosclerotic origin of both, CAE and distal coronary artery involvement.
Cor Vasa 1991
PMID:Angiographic evidence of coronary artery ectasia: our experience. 174 22

Research of the relevant international literature on HLA studies in patients with hypertrophic cardiomyopathy yielded controversial results. There are no studies, conducted in sufficiently large groups of patients, that would consider the different functional and morphological forms of the disease. Therefore, the authors carried out detailed typing of 60 Class I and II antigens in 117 patients known to suffer from hypertrophic cardiomyopathy. Values of the relative risk and chi-square test showed a number of possible associations. However, after correction for the number of antigens tested, only HLA-B21 was shown to have a significantly high frequency (in patients with the obstructive form and in those with advanced myocardial hypertrophy, defined as a wall thickness greater than 30 mm). An association with this antigen has previously been demonstrated in a number of cases of ischaemic heart disease, myocardial infarction of young people, and in hypertensive subjects. HLA typing may be helpful in recognizing forms which are not fully typical. In Czechoslovakia, HLA-B21 carriers are at increased risk of developing a serious heart disease manifesting already in young age.
Cor Vasa 1991
PMID:An immunogenetic study in hypertrophic cardiomyopathy. 181 Jul 2

The study analyses, first, the prevalence of risk factors of ischaemic heart disease among the male population of the city of Bishkek, aged 40-59 years (n = 5246) and, second, the efficacy of a preventive programme according to the development of risk factors in groups exposed to preventive measures of various intensity during 5 years. The prevalence of IHD risk factors in the given population was very high. In the group exposed to active preventive intervention a decrease in the prevalence of arterial hypertension, hypercholesterolaemia, smoking and low physical activity was registered after 5 years, compared to a group without active prevention.
Cor Vasa 1991
PMID:Prevalence of ischaemic heart disease risk factors among the male population in Frunze aged 40-59 years and results of a five-year prevention programme. 184 38

The authors offer their experience with diastolic function assessment using Doppler echocardiography in ischaemic heart disease. Information on the diastolic properties of the ventricle is obtained from recordings of the blood flow velocity curve in mitral and tricuspid valve orifices. Doppler echocardiography, allowing to monitor the velocity curve of ventricular filling, represents one of the most modern techniques of examination. Diastolic function is commonly significantly affected by ischaemic heart disease, not only in terms of energy requirements; other factors such as the volume of venous return, extent of ischaemia, its time course, and so on, come into play. Changes in myocardial rigidity and filling pressures are two factors which exert a substantial effect on the character of inflow curves. The article describes typical recordings obtained from individual clinical manifestations of acute and chronic states in ischaemic heart disease, and reviews the still limited body of data regarding the effect of drug and/or surgical therapy on the diastolic properties of the affected ventricle.
Cor Vasa 1991
PMID:Doppler echocardiographic assessment of the diastolic properties of the cardiac ventricle in ischaemic heart disease. 184 39

Mean values of cholesterol contents in low- and high-density lipoproteins, and the 10% and 90% cut-off points of their distribution were determined in random samples of men aged 35-64 years and resident in three Soviet cities (Kiev, Moscow, Novosibirsk) and two Polish regions (Warsaw, and Tarnobrzeg province). Comparative analysis revealed that, while having identical mean total cholesterol levels, the studied populations differ both in the character of cholesterol distribution in atherogenic and nonatherogenic lipoproteins and in their age dynamics. The lipoprotein spectrum was also compared with data of overall mortality and that from ischaemic heart disease and stroke in the respective areas. The comparison suggested a potential association between the incidence of these diseases and the incidence of individual lipid risk factors in the population. The regional specifics of the blood lipoprotein spectrum must also be considered when developing programmes of atherosclerosis prevention.
Cor Vasa 1991
PMID:A comparative analysis of the spectrum of blood lipoproteins in random population samples. A Soviet-Polish cooperative lipid project. 191 70

Eighteen patients were examined by echocardiography one month before, and one month after orthotopic heart transplantation (OHT). The right-heart echocardiographic parameters were compared with pulmonary haemodynamics. All recipients showed increased mean pulmonary artery pressure (PAP) (42 +/- 8 mmHg) and pulmonary vascular resistance 3.0 +/- 1.3 u.) before OHT. The causes of the pulmonary hypertension, and indications for OHT, were the end stage of dilated cardiomyopathy (n = 8), ischaemic heart disease (n = 9) and aortic valve disease (n = 1). After transplantation, the donor's right ventricle dilates due to the recipient's elevated pulmonary vascular resistance. The right ventricular dimension after OHT was greater than 30 mm in 1/3 of patients. The right ventricular diastolic dimension correlates statistically significantly with mean PAP of the recipient before the procedure. Right ventricular dilatation is accompanied by a mild degree of tricuspid insufficiency (in 89% of cases), as documented by Doppler examination. Neither the degree of right ventricular dilatation, nor the degree of tricuspid insufficiency show a tendency to progression during follow-up.
Cor Vasa 1990
PMID:Right ventricle in patients after orthotopic heart transplantation. 220 22


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