Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0151744 (
myocardial ischemia
)
31,282
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excessive generation of reactive oxygen species (ROS) is one of the main causes of
myocardial ischemia
-reperfusion (I/R) injury. In this study, we investigated the role of protein kinase C-interacting cousin of thioredoxin (
PICOT
; Grx3) during myocardial I/R using
PICOT
transgenic (TG) and knockdown (KD) mice. Infarction and apoptosis were attenuated in
PICOT
TG mice but exacerbated in
PICOT
KD mice upon I/R. In parallel, I/R-induced generation of ROS was attenuated in
PICOT
TG mice but exacerbated in
PICOT
KD mice. Angiotensin II (AngII)-mediated increases in ROS and free iron levels were also attenuated in cardiomyocytes isolated from
PICOT
TG mice but exacerbated in cardiomyocytes from
PICOT
KD mice. Accordingly, H
2
O
2
-mediated cell death was attenuated in cardiomyocytes isolated from
PICOT
TG mice but exacerbated in cardiomyocytes from
PICOT
KD mice. Taken together, these data show that
PICOT
alleviates myocardial I/R injury by regulating intracellular ROS and free iron levels. We suggest that
PICOT
presents a novel therapeutic strategy for myocardial I/R injury.
...
PMID:PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species. 2825 42
