Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study we analyzed allele and genotype distributions of 24 bp duplication of the CHIT1 gene in a sample of patients (N=300) with coronary artery disease (CAD) and in a control group (N=300) from central Corsica (France), with the aim to investigate the possible association between CHIT1 genotypes and CAD in Corsican population. Serum chitotriosidase activity is increased in individuals experiencing an ischemic stroke of atherothrombotic etiology and in subjects with ischemic heart disease. Our results suggest that 24 bp duplication of CHIT1 gene is not correlated with CAD in Corsican population, according to a previous study carried out on a Spanish sample. Gene prevalence and perhaps gene-disease associations vary according to ethnicity. Further studies, based on different ethnic groups, could be suitable to determine the implication of this polymorphism with respect to CAD.
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PMID:24 bp duplication of CHIT1 gene is not correlated with coronary artery disease in Corsica Island (France). 1791 51

We compared new non-lipid atherosclerosis indexes related to inflammation and macrophage stimulation (serum concentration of cystatin C, matrix metalloproteases and chitotriosidase activity) with common inflammatory (high sensitivity C reactive protein) and lipid markers in elderly persons and patients with atherosclerosis and ischemic heart disease who have undergone coronary bypass surgery.
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PMID:[Effect of statins on activity of matrix metalloproteases and serum concentration of cystatin C in patients with various risk of development of ischemic heart disease and in patients after coronary artery bypass surgery]. 2279 35