Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With improvements in life expectancy and as more and more people have access to modern medicine, non-communicable diseases are emerging as a health problem in both urban and rural communities in Myanmar. Of all non-communicable diseases, cardiovascular diseases (CVD) are known to be the major health problem. Since many studies that have been conducted in both developed and developing countries have shown a difference between rural and urban communities with regard to cardiovascular diseases, our study had the objective of finding out the prevalence of ischemic heart disease, hypertensive heart disease and rheumatic heart disease in a rural and urban community. The risk of obesity and smoking in the occurrence of CVD was also studied. A cross-sectional survey was conducted in three urban townships of Yangon City (Sanchaung, Latha and Pabedan) and one rural township of Hmawbi. The results showed that CVD were a health problem in both the urban and rural communities. Coronary heart disease was seen to be more prevalent in the urban townships than in the rural Hmawbi Township, but hypertension (HT) and rheumatic heart diseases (RHD) were more prevalent in the rural township of Hmawbi. Obesity which has been blamed as the major risk factor for CHD and HT in the developed countries was not found to be a risk factor in the study townships, but smoking was.
Asia Pac J Public Health
PMID:Prevalence of cardiovascular diseases in rural area of Hmawbi and urban Yangon city. 134 45

Though major differences exist in subcategory mortality levels, cardiovascular disease remains a leading cause of death among both Asian Chinese and Westerners. This paper examines the possible relationship between cardiovascular mortality and biochemical, diet and lifestyle factors based on two surveys in China. Statistically significant associations indicate five variables negatively correlated: molybdenum, oleic acid, liquor consumption (males), legumes, and age at first pregnancy with ischemic heart disease; molybdenum, oleic acid (females) and age at first pregnancy with hypertensive heart disease; and legumes and age at first pregnancy with stroke. Five variables were positively correlated: triglycerides and herpes antibodies with ischemic heart disease; salt and phosphorus (females) with hypertensive heart disease; and only albumin (males) with stroke. Some findings confirm those observed in the West (salt, triglycerides, herpes, legumes, oleic acid, and liquor), but molybdenum and age at first pregnancy have not been emphasized previously. Still others significant in the West have not been observed here, such as cholesterol and smoking.
Asia Pac J Public Health
PMID:Diet and blood nutrient correlations with ischemic heart, hypertensive heart, and stroke mortality in China. 134 47

Diabetes prevalence and complications rates were examined for the indigenous population of the Commonwealth of the Northern Mariana Islands in the western Pacific. Diabetes is common, with 4% of the population and 11% of adults having diagnosed diabetes. Diabetes is more common among females and islanders of Carolinian descent. End stage renal disease, hospitalizations for pneumonia, non-traumatic lower extremity amputations and retinopathy are more common than expected (with relative risks of 3.9, 3.0, 1.5 and 1.3, respectively, compared with diabetics in US), while diabetes-related mortality and hospitalizations for ischemic heart disease/cerebrovascular disease are less (with relative risks of 0.9 and 0.8). Implications for primary and secondary prevention of diabetes and its complications are discussed.
Asia Pac J Public Health
PMID:Diabetes in the indigenous population of the Commonwealth of the Northern Mariana Islands. 1005 Jan 96

In Zhejiang province economic development and changes in nutrition appear to have increased both life expectancy and nutrition-related chronic disease morbidity. Life expectancy is longer in urban populations than in rural and in both urban and rural females. From 1997 to 2002 urban females had an average life expectancy of 81.4 years. In 2002 the estimated incidence of ischaemic heart disease was higher in rural males and females whereas diabetes mellitus was higher in urban males and females. From 1990 to 2002 lung cancer had large increases in all groups, cancers of the oesophagus and stomach increased in rural males and females, and cancer of the large intestine increased 40 per cent in urban males. In 2002 deaths from cerebrovascular disease were much higher in rural males and females. Apart from differences in lifestyle factors between urban and rural, access to medical resources may also be relevant to the differences within the province in chronic disease rates and in life expectancy.
Asia Pac J Clin Nutr 2004
PMID:Nutrition-related disease and death in Zhejiang Province? 1522 83

Chronic illness is one of the major causes of mortality and morbidity among the elderly. To determine the prevalence and factors associated with chronic illness among the elderly in a rural community setting. A cross sectional study design was used. Stratified proportionate cluster sampling method was used to select respondents in Mukim Sepang, Sepang, Selangor, Malaysia. Out of 263 elderly residents (6.2% of the total population), 223 agreed to participate in the study giving a response rate of 84.8%. The prevalence of chronic illness among the elderly in Mukim Sepang was 60.1%. Out of 223 respondents, 134 were diagnosed as having chronic illness such as hypertension, diabetes mellitus, ischaemic heart disease, bronchial asthma or gout. Chronic illness was found to be significantly associated with functional dependence among the elderly (chi2=6.863, df=1, p<0.05). The prevalence of chronic illness among the elderly in the rural community is very high. Problems facing this age-group should be addressed comprehensively in order to formulate appropriate programmes for the health care of the elderly.
Asia Pac J Public Health 2004
PMID:Factors associated with chronic illness among the elderly in a rural community in Malaysia. 1562 88

Atherosclerosis of coronary arteries is a main cause of ischaemic heart disease (IHD). Matrix metalloproteinases, a super-family of zink-dependent enzymes, which are involved in the pathogenesis of atherosclerosis by the activation of migration and proliferation of smooth muscle cells and by the induction of destabilization of atherosclerotic plaques. Some observations suggest that C(-1562)T polymorphism of matrix metalloproteinase-9 (MMP-9) promoter predisposes to multivessel IHD. Therefore, the aim of our study was to evaluate the association between C(-1562)T MMP-9 polymorphism and angiographically-documented coronary atheroclerosis in 110 patiens. Genomic DNA isolated from peripheral blood nuclear cells was amplified by PCR method with pair of primers flanking the polymorphic regions and subsequently MMP-9 genotypes were identified by amplicon digestion with Pac I restriction enzyme. The T(-1562) allel was idientified by gain of restriction site. There were 67 CC homozygotes and 43 carriers of T allele (41 CT + 2 TT). No differences has been found among patiens with various number of significantly stenotic (>50%) coronary arteries (group 0, 1, 2 and 3, respectlively) in genotype distribution, age, prevalance of arterial hypertension, and plasma concentrations of triglycerides, cholesterol and fibrinogen. However, in subjects younger < 50 years, the frequency of T(-1562) allele was significantly higher in IHD patients as compared with controls (group O). Results of our preliminary study suggest, that C(-1562)T MMP-9 transition is associated with premature IHD in Polish patients.
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PMID:[The C(-1562)T polymorphism in the promoter of the matrix metalloproteinase-9 (MMP-9) gene and coronary atherosclerosis]. 1673 97

This paper compares body mass index, waist circumference, hip circumference, and waist-hip ratio as risk factors for ischaemic heart disease and stroke in Asia Pacific populations. We undertook a pooled analysis involving six cohort studies (45 988 participants) and used Cox proportional hazards regression to assess the associations of the four anthropometric indices with stroke and ischaemic heart disease by age, sex and region. During a mean follow-up of six years, 346 stroke and 601 ischaemic heart disease events (fatal and non-fatal) were documented. Overall, a one-standard deviation increase in index was associated with an increase in risk of ischaemic heart disease of 17% (95% CI 7-27%) for body mass index, 27% (95% CI 14-40%) for waist circumference, 10% (95% CI 1-20%) for hip circumference, and 36% (95% CI 21-52%) for waist-hip ratio. There were no significant differences between age groups, sex, and region. None of the four anthropometric indices had a strong association with risk of stroke. These data indicate that measures of central obesity such as waist circumference and waist-hip ratio are strongly associated with risk of ischaemic heart disease in this region. Therefore, we suggest that, along with calculation of body mass index, measures of central obesity such as waist circumference and waist-hip ratio should be undertaken routinely.
Asia Pac J Clin Nutr 2006
PMID:Central obesity and risk of cardiovascular disease in the Asia Pacific Region. 1683 18

A Indonesian Advisory Group on Fatty Acid Nutrition and Health was established in 2004 to consider the increasing incidence of nutritionally-related cardiovascular disease in Indonesia. Emerging international recommendations, often focused on dietary fat and may not have been relevant to the national situation. Traditional dietary patterns were apparently protective against ischaemic heart disease often with fat derived dominantly from a particular source like coconut, soy, peanut or fish. These fats were used in ways which promoted the use of potentially cardioprotective foods like legumes, vegetables, fruits and aquatic food. Optimal intakes of polyunsaturated fatty acids in Indonesia are likely to reflect both absolute intakes and the relationships between n-3 and n-6 fatty acids of longer chain lengths. This leaves some issues for active and continuing review, like the intakes of trans fatty acids, and the regulatory and food labelling implications. Some studies underway and others which need implementation will enable the Advisory Group to prepare a second report with more basis in Indonesian evidence. In the meantime, the Advisory Group has recommended that the AHA (American Heart Association) and ISSFAL (International Society for the Study of Fatty Acids and Lipids) recommendations obtain until the end of 2007.
Asia Pac J Clin Nutr 2007
PMID:Desirable intakes of polyunsaturated fatty acids in Indonesian adults. 1804 22

To determine the influence of personal medical history on mortality from cancer and other chronic diseases, participants in the JACC study were questionned and followed up. Consistent across the sexes, risk of deaths of all causes was increased with hypertension, diabetes mellitus, apoplexy, liver diseases, surgical operations, and blood transfusions. All cancers were similarly related to a history of diabetes and liver diseases, surgery and transfusions. In addition, risk of liver cancer was elevated with diabetes, liver disease, cholecystectomy, renal disease, surgical operations and blood transfusions. Apoplexy was related to a past history of blood transfusion and diabetes, the latter also predisposing to ischemic heart disease. Links with infectious disease were also elucidated. Clearly, a past medical history can exert a strong influence on chronic disease development.
Asian Pac J Cancer Prev 2007
PMID:Personal past history and mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). 1826 Jul 2

To determine the influence of family medical history on mortality from cancer and other chronic diseases, participants in the JACC study were questioned about tuberculosis, apoplexy, hypertension, heart disease, diabetes mellitus and malignant diseases and followed up. Consistent across the sexes, a family history of tuberculosis was apparently linked to reduced risk of lung cancer, and also lowered ischemic heart disease. No consistent findings were obtained for hypertension, diabetes mellitus or cancer.
Asian Pac J Cancer Prev 2007
PMID:Family history and mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). 1826 Jul 3


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