Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myocardial ischemia was shown to lead to modification of structural and functional organization of rat erythrocyte membranes. Thus, it was found that the activity of Na+, K+-ATP-ase markedly decreased, while accumulation of LPO products and of lysophosphatidylcholine (lyso--PC) took place in erythrocyte membranes of rats subjected to myocardial ischemia. Using nonpenetrating modifier trinitrobenzosulfonic acid, an increase in the content of modified phosphatidylethanolamine in erythrocyte membranes of ischemic rats was revealed as compared to the membranes of control animals. The intravenous administration of gangliosides (30 mg/kg) resulted in partial normalization of Na+, K+(-)ATPase activity, of LPO product and lysoPC content and of transbilayer distribution of lipids.
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PMID:[Ganglioside protection of the erythrocyte membranes in myocardial ischemia]. 133 4

Dual gated (DG) cardiac single photon emission computed tomographic (SPECT) studies at end-diastole (ED) and end-systole (ES) were acquired in 27 ischaemic heart disease (IHD) patients after intravenous injection of 555-740 MBq 99Tcm-MIBI. Acquisition parameters were: 180 degrees from LPO to RAO, 32 projections, 64 x 64 matrix, 75 cardiac beats per projection, 80 ms at ED and 80 ms at ES for each cardiac cycle. A computer program was developed to calculate the ED and ES left ventricular (LV) volumes and LV ejection fraction (EF). The computational approach is interactive, semi-automatic and iterative with built-in visual quality control. Short axis slices are used with corresponding ED and ES slices processed as pairs from apex to base. Left ventricular cavity pixels are identified and summed on a slice-by-slice basis. Myocardial pixels are similarly identified. The computed LVEF and ED and ES volumes have been correlated with those from contrast ventriculography (CV). The mean calculated EF for 27 patients was 53.6 +/- 10.7% from DG SPECT versus 55.3 +/- 12.1% from CV (NS). The EF linear correlation coefficient was r = 0.97.
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PMID:Left ventricular ejection fraction and volumes calculated from dual gated SPECT myocardial imaging with 99Tcm-MIBI. 144 37

The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ventriculography (LV). SPET images were obtained at rest and at peak exercise (Modified Bruce) 90 min after injection of 99Tcm-MIBI (650-850 MBq). Data were acquired in 30 min over 180 degrees (from 45 degrees RAO to 45 degrees LPO) with no correction for attenuation, using a 64 x 64 matrix. The presence of persistent (P) or reversible (R) perfusion defects (PD) was then correlated to the resting and exercise ECG and to the results of CA and LV. Of the 56 patients, 34 had reversible underperfusion (RPD), 46 persistent underperfusion (PPD) and 31 had both. The occurrence of RPD correlated well with the occurrence of exercise-induced ST segment depression and/or angina (27 patients of 34 patients, 79%) and with the presence of significant coronary artery disease (CAD) (33 of 44, 73%). In 45 of 46 patients (98%) PPD corresponded to akinetic or severely hypokinetic segments (LV) usually explored by ECG leads exhibiting diagnostic Q waves (42 of 46 patients, 91%). The scan was normal both at rest and after stress in four of 11 patients with no CAD, and in two of 45 patients with CAD. Finally, an abnormal resting scan was seen in seven of 11 patients with normal coronary arteries, of whom six had regional wall motion abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:99Tcm-MIBI single photon emission tomography (SPET) for detecting myocardial ischaemia and necrosis in patients with significant coronary artery disease. 146 70

The addition of antidepressants to combined treatment of IHD patients aroused not only mediated psychic benefit, but also positive shifts in metabolic and mediator regulation of chronic psychoemotional stress. Antidepressants administration results in lowering of total blood cholesterol and atherogenic lipoproteins, inhibits LPO, promotes normalization of cyclic nucleotides levels (cAMP and cGMP increase and decrease, respectively). Clinical course of the disease also improved (less frequent and severe attacks of angina pectoris and associated atypical pain syndrome, of arrhythmia paroxysms; exercise tolerance increased, hemodynamics improved). The arguments in favour of antidepressant use in coronary patients with anxiodepressive symptoms and social and psychological dysadaptation are provided.
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PMID:[The effect of antidepressants on lipid metabolism and the clinical course in IHD]. 790 28

A study was made as well as a comparison of values of the cholesterol (Chs) lipid fractions concentrations, and of those of the lipid peroxidation processes activity (LPP) and the gluthathione antioxidant system (AOS) status in male subjects aged from 45 to 59 years, healthy individuals and patients with stable angina pectoris and myocardial infarction (micro- and macrofocal) during cicatrizing stage (health resort rehabilitation stage). In patients with various forms of IHD total cholesterol is raised as are atherogenic lipoproteins, and atherogenicity index, intensification being noted of LPO along with a considerable decrease in functional potencies of AOS. Similar pattern of changes of LPO and AOS in patients with stable angina pectoris and myocardial infarction (MI) during cicatrization stage certainly warrants correction of these systems not only in acute phase of MI but at the stage of rehabilitation as well.
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PMID:[The oxidant and antioxidant systems in patients with stable stenocardia and with a history of small- and large-focus myocardial infarcts]. 790 Mar 51

The origin and development of ischemic heart disease (IHD) is attended with activation of lipid free-radical oxidation facilitating further advancement of the disease and with decrease of the organism's antioxidant protection. The antianginal drugs which are used in IHD treatment differ in their effect on the blood lipid composition and their peroxidation. beta-Adrenoblocking agents may cause proatherogenic disorders of the blood lipid graph, this increases the risk of IHD advancement. Long-acting nitro preparations are lipid-neutral. Calcium antagonists, mainly those of the nifedipin group, suppress LPO superactivity, possess a high antioxidant effect, and, probably, retard the advancement of coronary atherosclerosis and IHD.
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PMID:[Blood lipids, lipid peroxidation and the effect on them of antianginal preparations in ischemic heart disease patients]. 962 Nov 82

The state of the system lipid peroxidation-antioxidant defense (LPO-AOD) was studied in 187 patients with ischemic heart disease on combined balneorehabilitation. The balneotherapy comprised effervescent magnesium-calcium and effervescent arsenic mineral water, artificial baths. Balneorehabilitation produced optimal results in high functional capacity of LPO-AOD system. In low functional activity of the system LPO-AOD balneological procedures may impair adaptive mechanisms and provoke balneoreactions. Combination of balneofactors with diet including polyunsaturated fatty acids enhanced antioxidant blood activity and modified LPO.
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PMID:[The modulating action of balneotherapy on the peroxidation processes in patients with ischemic heart disease]. 977 Nov 40

Association of ischemic heart disease (IHD) with vascular affections of the brain is the cardiocerebrovascular syndrome having common pathogenetic mechanisms of formation in the structure of cardiovascular pathology. Some specificities were studied of the clinical course of IHD concomitant with hypertensive dyscirculatory encephalopathy (HDE) in 35 patients (main group), with 25 IHD controls free from manifestations of neurological symptomatology. In IHD HDE patients the anginous syndrome is characterized by a lesser dependency on time in each period of 24 hours and physical load and greater dependency on arterial pressure, meteofactors, it is often accompanied by cephalgia appearing with the intake of antianginal drugs, dizziness, memory, sleep disturbances. The main group patients demonstrated elevated levels of LPO products, those of lipid metabolism, and the AO system tension.
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PMID:[Characteristics of the clinical course of ischemic heart diseases in patients with hypertensive dyscirculatory encephalopathy]. 1145 23

The aim of the study was to examine changes in the system lipid peroxidation-antioxidant defense (LPO-AOD) in patients with ischemic heart disease (IHD) exercising on the bicycle in free load regime. A course of standard medication in IHD patients reduced the level of lipid peroxidation by 15.1% (p < 0.05), on the average, malonic dialdehyde (MDA)--by 21.4% (p < 0.05), but at the end of the treatment these parameters did not reach those of healthy subjects and remained higher than they had. The addition of bicycle exercise in the treatment reduced LPO to the level of healthy subjects. AOD also changed in trained IHD patients: catalase activity rose in the trained patients by 22.6% (p < 0.001), on the average, that of superoxide dismutase--by 19.0% (p < 0.05). Total antioxidant activity of erythrocytes in trained patients rose by 24.0% (p < 0.01), total antioxidant activity of plasma increased by 43.3%. Thus, free bicycle exercise raises antiradical potential of blood in IHD patients. The effect of the exercise was the highest on the enzymes of AOD system.
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PMID:[Correction of free radical processes in patients with ischemic heart disease using bicycle exercise with free choice of load]. 1720 Dec 15