Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In eight study populations in which the medians of total plasma cholesterol did not differ significantly (mean 5.8 mM, p greater than 0.05) and therefore did not correlate with the IHD mortality (r2 = 0.05), the median of absolute plasma level of vitamin E (alpha-tocopherol) was inversely related to the IHD mortality (r2 = 0.55; p = 0.003). Vitamin A behaved similarly (r2 = 0.51; p = 0.046). The absolute levels of vitamins E and A together with cholesterol predicted (by multiple regression analysis) the IHD mortality of these eight populations fairly well (r2 = 0.81; p = 0.06). Considering all 12 study populations analyzed thus far, total plasma cholesterol correlated with the IHD mortality directly as expected (r2 = 0.51; p less than 0.01), but the median of the plasma alpha-tocopherol individually standardized for cholesterol and triglycerides (220 mg/dL + 110 mg/dL, respectively) maintained a strong inverse association with the IHD mortality (r2 = 0.49; p = 0.01). In the partial regression analysis, lipid-standardized vitamin E exhibited an even stronger inverse correlation with IHD mortality (r2 = 0.69; p less than 0.001). Again, vitamin A behaved similarly to vitamin E, that is, after lipid-standardization of individuals (r2 = 0.33; p = 0.07), as well as in the cholesterol-independent partial regression analysis (r2 = 0.74; p less than 0.001). Both vitamins may act singularly, for after lipid-standardization they vary de facto independently (rs = 0.012) in individuals. The combination of vitamins E and A as obtained by multiple partial regression predicted the actual IHD mortality to a large extent (r2 = 0.89; p less than 0.001), whereas the three-variable prediction model, with the median of total cholesterol and of individually lipid-standardized vitamins E and A, fit the actual IHD mortality of these 12 populations almost completely (r2 = 0.94; p less than 0.001). In conclusion, the plasma status of vitamins E and A are important, hitherto underrated risk factors of IHD, which may act independently, but can, if combined, predict at least 53% of the cross-cultural differences of IHD mortality. After inclusion of total cholesterol into a multivariate model, up to 94% of the IHD mortality can be predicted. The present epidemiological data are in agreement with the hypothesis that these vitamins have physiological functions in the protection of lipoproteins against peroxidation and atherogenic apo-B modifications, respectively, but that does not exclude additional beneficial effects of vitamin E and A in the arterial wall.
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PMID:Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. 262 97

This paper presents a trend-free regression model for analyzing the effect of changes in food intake on disease specific mortality rates. The statistical effect of changes in food consumption of the Israeli population during 1949 to 1977 on concurrent mortality rates from cancer, heart disease, peptic ulcer, and diabetes mellitus were investigated by the suggested model. The regression analyses reveal the following: 1) The major statistical effects of progressive dietary changes (during 28 yr) on mortality rates lagged by 1 or 2 yr. 2) None of the variables was consistently and statistically significantly related to cancer mortality. 3) Vitamin A was consistently in statistically significant negative association with mortality rates. This suggests that increased consumption of vitamin A may prove to reduce mortality rates due to heart disease and peptic ulcer. 4) All the investigated mortality rates were in statistically significant positive association with increasing total fat consumption. Mortality rates of ischemic heart disease as well as of hypertensive and cerebrovascular diseases were in positive association with both plant fat and animal fat. These findings suggest that reduced total fat intake may prove to reduce the investigated mortality rates. 5) Diabetes mellitus was in statistically significant inverse association with the average per capital consumption of fruits and vegetables. Our results suggest that increased carbohydrate consumption may reduce diabetes mellitus mortality. The above hypotheses derived from the model and the general utility of the model may be demonstrated by studies of data from other countries.
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PMID:Association between dietary changes and mortality rates: Israel 1949 to 1977; a trend-free regression model. 727 Apr 81