Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analog pressure signals (catheter-tip manometers) from the left atrium, left ventricle, and aorta and a flow signal from the arota were obtained in 25, open-chest, anesthetized dogs in which 115 episodes of ischemia were produced in an area of the left ventricle subtended by the distal left anterior descending coronary artery and its last major diagonal branch. The left ventricular pressure and its first derivative (dP/dt) were displayed as an X-Y loop. The character of this loop went through a unique series of dynamic changes in 110 of the 115 ischemic episodes, indicating that this is a useful tool for monitoring myocardial ischemia. Spectrum pairs of the above signals were analyzed with digital computational transfer functions in 14 ischemic episodes of three experiments and preliminary assessment reveals unique pole and zero changes in many pairs during each episode which also may prove to be a useful indicator of the hemodynamic disturbance incurred during myocardial ischemia.
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PMID:Apperceptive signals demonstrating the dynamic disturbance of myocardial ischemia. 75 16

Geriatric patients committed to mental institutions often die from infections, neoplasia, drug-related disorders, or cardiopulmonary failure. Myocardial infarction is not usually implicated as the cause of death in these patients. In comparison, infarct-related deaths are quite common in normal patients of comparable age. This observation may, in part, be due to the fact that physicians treating psychiatric patients may become preoccupied with the patients' mental state, and pay less attention, inadvertently, to other medical disorders. Also, ischemic heart disease may present in an atypical manner in such patients, thus masking detection by the physician. Careful evaluation and observation of these patients for evidence of ischemic heart disease and myocardial infarction are essential to their care, because early detection of such disorder and prompt therapy may save the patient's life.
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PMID:Fatal myocardial infarction in a state geriatric mental facility. 737 59

The objective of this part of the first cross-section of the longitudinal study of a cohort of 70 year olds in Jerusalem was to survey the gastrointestinal symptoms and signs of this heterogeneous population and thus contribute to the knowledge of the development of gastrointestinal diseases in this age group. A total of 605 persons replied to a home-visit questionnaire gathering data on socioeconomic and migration variables. Later on, 463 of these attended an examination at the Geriatric Research Institute where an in-depth anamnesis and physical examination were conducted. A battery of biochemical and hematologic blood tests were performed as well as urine analysis, ECG, and pulmonary function tests. At 3 year follow-up, the interviewed subjects, subjects examined in the hospital, and the control group consisting of 70 year olds who were not examined, were compared. By the measures of disease-specific mortality and hospital morbidity, the three groups were found to be similar, demonstrating that the sample population does represent the total Jerusalem 70-year-old population. This paper describes the symptoms, signs and laboratory results of the gastrointestinal part of this study. Up to a third of the subjects complained of upper gastrointestinal symptoms, most prominent of which was heartburn. Almost 10% of subjects complained of abdominal pain occurring at least once a week, but less than 1% noted left lower quadrant pain. There was a direct association between upper abdominal pain and symptoms of ischemic heart disease. The second part of this study, which began in 1996, will provide additional information regarding the natural history of these complaints.
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PMID:The Jerusalem 70 year olds longitudinal study: gastrointestinal findings. 881 73

Several studies have reported the prevalence of medical conditions or investigated the relationships between the oral health status and general health conditions in the elderly. However, the relationship between medical conditions and oral health among the elderly is not well-described. Previous studies have not clearly identified a consistent association between medical conditions and oral health, specifically edentulism and tooth loss. The purpose of this study was to investigate the relationships between medical conditions and oral health, as assessed by edentulism and missing teeth, in an institutionalized elderly population. A systematic sample (n = 175), stratified by age and sex, was drawn from nursing home patients treated by the University of low' as Geriatric Mobile Unit (GMU) team. Data were extracted from GMU dental records, regarding history of medical conditions, medications, dental history, dentate status, and tooth-by-tooth conditions. Mean numbers of missing teeth were significantly higher among those who had a history of atherosclerotic vascular disease, heart failure, ischemic heart disease, and joint disease. Subjects who had a history of atherosclerotic vascular disease, heart failure, ischemic heart disease, and joint disease were more likely to be edentulous than subjects who did not have a history of those diseases. The biological basis for these relationships between dentate status and systemic medical conditions is unclear and warrants further study.
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PMID:Medical conditions associated with missing teeth and edentulism in the institutionalized elderly. 968 Sep 23

The prevalence of depression after stroke shows considerable variability. Predictors of depression are also not consistent between studies. The aim of this study was to study the prevalence of depression, as well as to study different determinants for depression and life satisfaction one year after a first-ever stroke. One year after the event, we screened survivors (n=253) in a population-based stroke study for depression using the Geriatric Depression Scale. The DSM-IV criteria were used to diagnose depression. Patients were asked how well they were satisfied with life in general. Predictors were evaluated in univariate and multivariate regression models. We found that 37% of the patients crossed cutoff on the Geriatric Depression Scale, and that 27% had a minor or major depression according to the DSM-IV criteria. Independent predictors in multivariate analysis were functional outcome, as measured by the Modified Rankin Scale, ischemic heart disease, and non-lacunar infarction. Independent predictors for a low life satisfaction were depression and functional outcome. We concluded that a low functional outcome predicts depression. Depression has a major impact upon life satisfaction one year after a stroke. Other potential predictors evaluated in this study were of less importance. Active rehabilitation may improve functional outcome, and thence influence depression positively. Also, depression is medically treatable. Follow-up strategies should include measures to detect and manage depression. Traditional scales and definitions of depression may be less reliable in the oldest old.
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PMID:Prevalence and predictors of depression at one year in a Swedish population-based cohort with first-ever stroke. 1790 50

Parkinson's disease is a chronic neurodegenerative movement disorder affecting people mainly beyond their 50s. Geriatric patients with Parkinson's disease experience a specific profile of comorbidities. Multimorbidity and resulting polypharmacotherapy are frequent at this age. Comorbid diseases, widely spread, involve arterial hypertension, ischemic heart disease, heart failure, atrial fibrillation, polyneuropathy, diabetes mellitus, cerebrovascular disease, sarcopenia, and frailty. Following years of drug development, levodopa is still the most effective drug for the treatment of motor symptoms. However, a wide range of other drugs are available with specific effects, contraindications, and complications. The treatment of geriatric patients with Parkinson's disease is challenging and requires the cooperation of multidisciplinary teams. A careful assessment of a patient's Parkinson's disease symptoms, comorbidities, medication, vital signs, and resources is crucial for an effective and safe therapy. Laboratory tests can assist in the identification of contraindications for specific treatments. Identifying potentially inadequate drugs from prescription lists can lead to a better targeted treatment for geriatric patients with Parkinson's disease. Future research should help develop a more evidence-based therapy of geriatric patients with Parkinson's disease. For this purpose, randomized controlled trials of geriatric patients are urgently needed. An international register concerning issues of safer drug application and monitoring could help to implement a better treatment.
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PMID:Safety and Tolerability of Pharmacotherapies for Parkinson's Disease in Geriatric Patients. 3093 78