Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The association of idiopathic hypertrophic subaortic stenosis (IHSS) with significant coronary atherosclerosis is little known, only 43 cases being available in the literature, 2 of which are personal ones. But the incidence of this association has certainly been underestimated. It is especially found from the sixth decade onwards, and at least 20% of patients with IHSS in and above the age group have stenosing lesions of the coronary artery. It is almost impossible to establish the presence of associated coronary abnormalities from the clinical features of from electrocardiogram. It does however seem worthwhile looking for this condition in IHSS when there is refractory chest pain, especially to beta-blockers, particularly if the patient is aged over 50 and has risk factors for ischaemic heart disease. It is also good to find IHSS associated with known coronary artery disease by using simple non-invasive techniques such as phonomechanocardiography and especially echo-cardiography; it is important not to miss the myocardial lesion and to treat concurrently if there is likely to be an indication for dealing with the coronary arteries surgically. The beta-blockers are the treatment of choice for both conditions, together with anticoagulents. If they fail, myectomy or myotomy together with aorto-coronary bypass graft should be considered.
Arch Mal Coeur Vaiss 1978 Sep
PMID:[Obstructive cardiomyopathy and associated coronary atherosclerosis. Review of the literature and report of 2 personal cases]. 10 92

Intravenous infusion of trinitrin (0.38 +/- 0.25 mg/hour) during rapid atrial pacing reduced pulmonary capillary pressures, cardiac output, coronary blood flow and myocardial oxygen consumption. At these dosages trinitrin allows patients with ischaemic heart disease to undergo atrial pacing in the best conditions by maintaining the pulmonary capillary and systemic arterial pressures and myocardial lactate production within limits close to the basal values. The beneficial effects last during the recovery period after the termination of pacing and of the intravenous infusion.
Arch Mal Coeur Vaiss 1979 Aug
PMID:[Effects of intravenous trinitrin infusion on systemic and coronary circulations during atrial electric stimulation]. 11 32

The findings after biochemical analysis of heart muscle taken at autopsy are given in this preliminary communication. Human myosin is made up of two heavy sub-units and two light sub-units: it is similar to cardiac myosin found in other mammals, but is different in certain characteristics, particularly immunological ones. Tropomyosin is made up of two different sub-units. The normal human heart contains 1 mg of collagen and 130 microgram of desoxyribonucleic acid (DNA) per 100 mg of fresh tissue. The degree of cardiac hypertrophy correlates with the increase total DNA within the heart, and with the lowering of myofibrillary Ca2+ ATPase, the concentration in the collagen remaining unchanged providing there is no ischaemic heart disease. These techniques may be used to quantify several factors, such as the degree of sclerosis or the nuclear mass in ill-understood conditions such as the primary cardiomyopathies.
Arch Mal Coeur Vaiss 1978 Sep
PMID:[Biochemistry of myocardium taken at autopsy. Preliminary report]. 15 17

100 patients (median age 79 years) were given anticoagulant therapy (ACT) for a period of time averaging 5 years 3 months (522 follow-up years).--Out of 3 522 Quick tests, converted into prothrombin times and all carried out in the same laboratory, the prothrombin time was at or less than 32% in 60.5%, and 34% in 69.6% of the tests.--The mean therapeutic doses were less than 27% of those for adults, and were decreased by 3 mg of phenindione per year over the age of 75, only the actively treated cases being retained.--The risks are the same as those for the middle-aged adult. They depend more on the quality of the investigations than upon age. In the group which has been studied, slight or frank haemorrhagic complications (0.05/year/patient) were the result of a demonstrable overdosage in only one case in four. They were not responsable for any deaths in this series.--because of the referral patterns, the patients studied consisted of 79 with ischaemic heart disease, 27 with peripheral vascular disease, 9 cerebrovascular accidents, and 6 with thrombo-emoblic problems, not counting the 23 complications during the course of the study. In those patients with ischaemic heart disease, well-regulated anticoagulant treatment was associated with a favourable clinical course, and the correlation was significant.--there is not argument against the administering of a full and prolonged course of ACT to a patient of more than 75 years of age.
Arch Mal Coeur Vaiss 1977 May
PMID:[Long-term anticoagulant therapy in subjects over 75 years of age. 100 cases]. 40 65

The Paris prospective study in an epidemiological study of 7,453 middle-aged men born in France, and initially free from ischaemic heart disease. The current mean follow-up time is 4 years. The mean annual incidence is 5.1 per 1000, which is about one half that found in similar american studies. This incidence is related to the cholesterol level, to the blood pressure, to cigarette consumption when the smoke is inhaled, to diabetes mellitus, and to major abnormalities on the electrocardiogram. These five factors are mutually independant in their prediction of the risk of future illness. A formula has been derived by statistical analysis, and takes these five factors into account: the incidence of illness rises exponentially as a function of this formula. New cases of ischaemic heart disease are distributed, but with a very patchy incidence, in this population, of which only a very small number remain disease-free. A table has been drawn up to show the probability of a middle aged male contracting ischeamic heart disease within 4 years, and takes the 5 factors into account: this probability varies between 0.5 per cent and 34 per cent.
Arch Mal Coeur Vaiss 1977 May
PMID:[Incidence and evaluation of the risk of coronary disease. Prospective study in Paris]. 40 66

A study of 345 patients with ischaemic heart disease due to coronary arteriosclerosis which had been demonstrated by coronary arteriography, and seen between November 1967 and December 1974, was directed towards finding out what had happened to the patients so that, by an actuarial study of their survival, the prognostic significance of the arteriographic and ventriculographic studies could be determined. The prognostic value of the clinical findings has shown the importance:--of the presence of clinical left ventricular failure;--of the presence of coronary insufficiency with frequent attacks; of the presence of sequelae of infarction as seen on the ECG at rest;--on the length of the symptomatic history before arteriography. The assessment of the prognostic potential of the arteriographic findings has emphasised:--the fundamental importance of diffusion of stenoses and occlusions of several main coronary trunks;--the high risk if the lesion affects the left coronary trunk; the high risk of prognostic significance of lesions on the IVA. The prognostic significance of ventricular lesions as demonstrated on ventriculography in the right anterior oblique incidence has shown the sinister significance of extensive lesions of more than two or three of the seven ventriculographic segments and of lesions with dilatation, whereas very localised static plaques hardly influence the prognosis at all.
Arch Mal Coeur Vaiss 1977 Jun
PMID:[Study of survival in angiographically determined ischemic cardiopathies: Apropos of 345 medically treated patients]. 40 73

Eight patients with chronic congestive cardiac failure secondary to ischaemic heart disease performed submaximal supine exercise before and after 5 mg sublingual isosorbide dinitrate (ISDN) at the time of cardiac catheterisation. Exercise before ISDN produced a poor response in left ventricular performance. After ISDN this response was significantly improved. Compared with the control exercise period cardiac index (CI) increased from mean 2.9 to 3.5 l/mn/m2 (p = less than 0.0025), stroke volume index (SVI) from mean 24 to 29 ml/m2 (p = less than 0.0005) and left ventricular stroke work index (LVSWI) from mean 22 to 28 g-m/m2 (p = less than 0.0025). Although ISDN reduced LVEDP significantly at rest, there were associated small but significant falls in CI, SVI and LVSWI. The improvement in exercise cardiac index was related to the ejection fraction, or the ejection fraction of the contractile section where a left ventricular aneurysm was present. ISDN may be effective in improving exercise tolerance in ambulant patients with chronic congestive cardiac failure.
Arch Mal Coeur Vaiss 1978 Mar
PMID:Haemodynamic effects of isosorbide dinitrate in patients with congestive cardiac failure at rest and during submaximal supine exercise. 41 97

In order to study factors influencing posterior wall thickness during diastole, echocardiograms showing the septum, mitral valve and posterior wall endocardium and epicardium in 15 normal subjects and 49 patients with heart disease were digitized. Maximum wall thickness, minimum cavity dimension and the onset of mitral valve opening are normally synchronous, and an early period of rapid wall thinning, at a peak rate of 10.7 +/- 1.7 cm/sec corresponds closely to rapid filling. In patients with ischaemic heart disease the peak rate and duration of rapid thinning were normal, but thinning preceded mitral valve opening (mean 50 msec). In 11 of 17 patients with hypertrophic cardiomyopathy the peak rate of thinning was reduced and in 2 it was increased. There was a close correlation between the peak thinning rate in this group and the peak rate of increase in dimension. In mitral stenosis peak thinning rate was frequently reduced but in some patients was normal, with the reduced rate of increase in cavity dimension maintained by reversal of septal movement. We conclude that rapid thinning is an intrinsic property of the ventricular wall which is normally associated with rapid filling, but which may be dissociated from filling by asynchronous relaxation or inflow obstruction, or may be modified by myocardial disease.
Arch Mal Coeur Vaiss 1978 Mar
PMID:Diastolic changes in left ventricular wall thickness studied by echocardiography. 41 5

Report of seven cases of intermittent left posterior hemiblock in subjects with acute ischaemic heart disease. The electrocardiograms of all the patients (together with the coronary arteriography in three cases) have shown the presence of two different areas of ischaemia: the anterior wall and the diaphragmatic wall of the left ventricle. In three patients acute coronary ischaemia was present in both areas; in the other cases one myocardial wall only was involved.
Arch Mal Coeur Vaiss 1975 Aug
PMID:[Transient left posterior hemiblock in acute ischemic cardiopathy]. 81 40

As part of the first examination conducted in the Paris Prospective Study, 6 565 healthy males aged between 42 and 53 years underwent a submaximal exercise test on the bicycle ergometer. Ischaemic changes in the ST segment during or after exercise were noted in 6% of the tests. The predictive value of these changes for the development of ischaemic heart disease after 4 years has been assessed. The risk of sequelae is 3.2 times greater in this group than in the group with no changes. The variations of this risk with the precise timing of the onset of these ischaemic ST segment changes during the course of the test and with the type of heart disease have been studied.
Arch Mal Coeur Vaiss 1976 Dec
PMID:[Prognostic value of ischemic changes of the electriccardiogram during and after exertion in an active male population]. 82 61


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