Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Obstructive sleep apnoea (OSA) is described by some authors as a potentially lethal disease and by others as an almost harmless condition. Excessive daytime sleepiness, neuropsychological dysfunction, altered quality of life, cardiovascular disease (systemic and pulmonary hypertension, cardiac arrhythmias, stroke and ischaemic heart disease) and increased mortality have been described as OSA complications. There is little argument that OSA may determine sleepiness, alter cognitive functions, and worsen quality of life, although with great interindividual variability: this should induce OSA to be considered an important illness per se, since sleepiness in OSA was shown to lead to important consequences, like road traffic accidents. Besides, OSA may interact with coexisting cardiac and respiratory disease and favour the appearance of heart and respiratory failure. Therefore, OSA is certainly also worth careful consideration as an important aggravating factor of other diseases. The evidence that obstructive sleep apnoea is an independent risk factor for cardiovascular complications other than owing to the recurrent transient blood pressure surges associated with apnoeas during sleep, and for an increased mortality is more conflicting. More studies are necessary to identify which characteristics of obstructive sleep apnoea may be considered important markers of its severity and as risk factors for different possible complications.
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PMID:What is the evidence that obstructive sleep apnoea is an important illness? 1006 35

Sleep-disordered breathing (SDB) is associated with a range of manifestations of cardiovascular disease such as stroke, ischemic heart disease and heart failure, and it is known to cause excessive daytime somnolence and be associated with traffic accidents. Therefore, it is important to detect SDB in the early stages. We investigated the prevalence of SDB using a portable monitoring system in 81 commercial drivers. We then analyzed predictive factors for SDB using their health examination records of the same fiscal year. The prevalence of moderate to severe levels of SDB reached 28.3% in all subjects. Multivariate analysis showed that the predictive factors which significantly correlated with SDB were : presence of glucose metabolism disorders (odds ratio [OR] 6.745), weight gain greater than 10 kg from age 20 (OR 5.374), and aging (OR 1.136). These results suggest that health examination records could help detect a high-risk group of SDB, which is important because its early diagnosis could prevent commercial driver traffic accidents.
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PMID:[The prevalence of sleep-disordered breathing among commercial drivers and analysis of predictive factors based on health examinations]. 2159 52