Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study examines whether men who were born outside marriage in early twentieth century Sweden run a higher risk of dying from ischaemic heart disease (IHD) in middle and old age compared to men who were born inside marriage. Analyses are based on the male half of the Uppsala Birth Cohort Study, Sweden, consisting of all 7411 boys who were born alive at the Uppsala Academic Hospital during the period 1915-1929. The statistical method used is Cox regression. The results demonstrated a statistically significant excess mortality among men born outside marriage, which could not be explained by either social class of origin or birth weight for gestational age. Instead, this elevated mortality was largely explained by the more than doubled mortality risk among those men born outside wedlock who never married in relation to the corresponding group of men born to married parents. Even when three indicators of adult socio-economic status were adjusted for, men who never married and were born outside marriage still ran a 93 per cent higher risk of dying from IHD than men who never married but were born inside marriage. This intervening effect of adult marital status was restricted to the category of never married men. Thus, although divorcees demonstrated an even higher mortality risk in relation to the married than did those who never married, this was equally true for men born inside and men born outside marriage. In the concluding section of the paper I argue that these findings should be understood in terms of the childhood social stigma that the illegitimate children experienced. This stigma may have resulted in an increased susceptibility, which in combination with the "failure" in adulthood to comply with the established norms of society regarding matrimony led to higher levels of IHD mortality in middle and old age.
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PMID:Born out of wedlock and never married--it breaks a man's heart. 1279 91

Depression is common in patients with ischemic heart disease. According to mental health surveys, approximately one-fifth of the patients with angiographic evidence of coronary artery disease have major depression.[1] It is well-recognized that stigma associated with mental disorders leads to individuals avoiding treatment or concealing treatment for them. We report a case of serotonin syndrome that occurred during postoperative period in a patient who underwent coronary artery bypass grafting. The patient was receiving 60 mg/day fluoxetine for the last 4 years, which she and her attendants concealed during the preoperative evaluation. To our knowledge this is the first case of serotonin syndrome, reported in biomedical literature, in a postoperative patient. We suggest that history taking should also focus on antidepressant drug intake by patients. If serotonin syndrome occurs in such patients aggressive and timely management can help avert mortality.
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PMID:Serotonin syndrome in a postoperative patient. 2177 86

Tobacco cessation is an important intervention to reduce mortality from ischemic heart disease, the leading cause of death in India. In this study, we explored facilitators, barriers, and cultural context to tobacco cessation among acute coronary syndrome (ACS, or heart attack) patients and providers in a tertiary care institution in the south Indian state of Kerala, with a focus on patient trajectories. Patients who quit tobacco after ACS expressed greater understanding about the link between tobacco and ACS, exerted more willpower at the time of discharge, and held less fatalistic beliefs about their health compared to those who continued tobacco use. The former were motivated by the fear of recurrent ACS, strong advice to quit from providers, and determination to survive and financially provide for their families. Systemic barriers included inadequate training, infrequent prescription of cessation pharmacotherapy, lack of ancillary staff to deliver counseling, and stigma against mental health services.
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PMID:Tobacco Cessation Among Acute Coronary Syndrome Patients in Kerala, India: Patient and Provider Perspectives. 3054 27