Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To appraise the diagnostic significance of Innerfield's serum test, 40 patients with ischemic heart disease were examined; 18 of them had angina pectoris, 22 myocardial infarction, in the acute of subacute stage, 15 hypertensive disease, and 27 patients had rheumatic heart disease. It is shown that the blood fibrinolytic system was depressed in most patients. A shorter serum test time was characteristic of these diseases when their course was complicated by thromboembolism. With due consideration for the data on the state of the blood coagulation and anticoagulation systems, the serum test may be used for identifying the prethrombotic condition in patients with various cardiovascular diseases.
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PMID:[Importance of Innerfield's serum test in the diagnosis of prethrombotic and thrombotic states in various cardiovascular diseases]. 67 17

Aggregation of erythrocytes was determined in 50 patients with angina pectoris and myocardial infarction and in 20 subjects of the control group by rheoscopy after Schmid-Schoenbein. It is shown that in patients with ischemic heart disease aggregation of erythrocytes is considerably increased and the hydrodynamic strength of the aggregates is greater. The erythrocyte aggregation curve is some patients with ischemic heart disease was of a biexponential character in distinction to that in subjects of the control group, which was of the monoexponential type. It was found that the increase in the strength of the erythrocyte aggregation and in the rate of aggregate formation was due to fibrinogen and its complex compounds with decomposition products.
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PMID:[Erythrocyte aggregation and fibrinogen derivatives in ischemic heart disease]. 67 18

The functional resistance of blood platelets, the reserve and active forms of histamine and serotonin, and the activity of monoamine oxidase and histaminase were studied in 5 healthy subjects, in 64 patients with acute, subacute and rehabilitation stages of myocardial infarction, and in 33 patients during frequent attacks of angina pectoris and after their total subsidence. On the grounds of the data obtained, the authors conclude that: (1) the drastically disturbed blood platelet resistance, megathrombocytosis, and marked decrease in the content of reserve amine forms in ischemic heart disease should be considered an additional risk factor; (2) agents which improve blood platelet vital activity and/or block the release reaction should be included in the therapeutic program for patients suffering from ischemic heart disease with heightened risk factors.
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PMID:[Thrombocyte functional resistance and histamine and serotonin metabolism in ischemic heart disease]. 67 19

The clinical course of ischemic heart disease was followed-up for 3 to 5 years after coronarography in 91 patients with atherosclerotic affection of the coronary arteries who had not been given purposeful treatment. In 30.8 per cent in cases the clinical picture of the disease grew worse: angina of effort became more frequent angina at rest occurred (19.8%), and myocardial infarction (7.7%) and symptoms of circulatory insufficiency (3.3%) developed. A lethal outcome was recorded in 16.5% of cases. A connection between the extent of the atherosclerotic process (the number of vessels involved) and the advancement of the disease was revealed.
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PMID:[Dynamic observation data on the course of ischemic heart disease]. 67 22

A woman with Prinzmetal's variant angina had spontaneous attacks of myocardial ischemia characterized by severe chest pain, hypotension, inferior ST-segment elevation, transient complete heart block and selective right ventricular dysfunction. Despite initial improvement following intravenous administration of atropine and sublingual administration of nitroglycerin she died of cardiogenic shock. Autopsy showed normal coronary arteries and acute pericarditis, more pronounced over the right side of the heart. It is postulated that the pericardial inflammation elicited severe spasm of the subjacent right coronary artery.
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PMID:Prinzmetal's angina, normal coronary arteries and pericarditis. 67 98

The apexcarotis diagram is a new mechanocardiographic method, uniting into a single diagram synchronous recordings of the carotidogram and apexcardiogram. Characteristic features of the apexcarotis diagram (ACD) in ischaemic heart disease with angina pectoris are the reduction of the area of ventricular ejection with a turn to the right toward the point S (p less than 0.001) and an extension of the diastolic subsegment A by more than 10% (p less than 0.001). In patients with myocardial infarction, in addition to the above changes, there occur a reduction of the area of ventricular filling (p less than 0.01) and an enlargement of the angle alpha (p less than 0.02). In 8 patients with angina pectoris and 7 patients with myocardial infarction, the coronary disease was established by coronary angiography as well as by catheterization of the right and left heart. In these patients, a reduction of the area of ventricular ejection was found, which was closely correlated with the elevation of left ventricular enddiastolic pressure (r = -0.72, p less than 0.001).
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PMID:Application of the apexcarotis diagram in ischaemic heart disease with angina pectoris and myocardial infarction. 67 89

The rheologic properties of blood were studied in 40 patients with ischemic heart disease both with affected and with intact cardiac coronary arteries (according to the findings of angiography) and in 13 persons with cardialgia due to vegetovascular dystonia. Significant hemorheologic pathology according to all values was revealed in patients with ischemic heart disease. It was noted that the growth of the fluidity threshold depends on the developing pathologic erythrocyte aggregation which is not associated with changes in the concentration of plasma fibrinogen. The importance of disorders in blood rheology in the origin of angina pectoris and myocardial infarction is discussed.
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PMID:[Rheological properties of the blood in ischemic heart disease]. 69 50

The observations cover 96 male patients, aged from 30 to 61 suffering ischemic heart disease with clearly manifested stenocardia. The diagnosis in all patients was made on the base of a thorough clinical examination, the results from the electrocardiography and the selective coronarography. The data obtained from the clinical instrumental and clinical-angiographic examinations reveal that a correlation exists between the stage of the coronary arteries lesions, the patients's age, number of previous myocardial infarctions, severity of stenocardia and the state of the coronary reserve. The extent growth of the coronary arteries lesion goes in parallel with the patients' age advancement, the number of previous myocardial infarctions, severity of stenocardia and the diminution of coronary reserve. In this respect the character of stenocardia and the state of coronary reserve have the highest informative value. Our examinations failed to establish any correlation between the stage of the coronary arteries lesion and the stage and eytension of myocardial lesion on the electrocardiogram as well as between the stage of coronary arteries lesion and the duration of the illness.
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PMID:[Clinical instrumental and clinical angiographic studies of patients with the anginose forms of ischemic heart disease]. 69 31

Mitral leaflet prolapse syndrome has been associated with anginal chest pain, atypical chest pain, electrocardiographic abnormalities and positive stress electrocardiograms. These features overlap those of ischemic heart disease. Furthermore, coronary artery disease is frequently associated with mitral leaflet prolapse. This study evaluated the usefulness of stress myocardial scintigraphy in distinguishing these two disorders. Thirty-two patients with an angiographic diagnosis of mitral leaflet prolapse were studied. Of the 22 patients (8 men and 14 women, mean age 48 years) with a normal coronary arteriogram, 5 had "typical" angina pectoris, 6 had resting electrocardiographic abnormalities and 6 had a positive stress electrocardiogram; all 22 patients had a normal stress myocardial scintigram. Of the 10 patients (7 men and 3 women, mean age 55 years) with at least 70 percent stenosis of one coronary artery, 6 had "typical" angina pectoris, 1 had resting electrocardiographic abnormalities and 7 had a positive stress electrocardiogram. Nine of these 10 patients had one or more demonstrable perfusion defects on stress myocardial scintigrams. It is concluded that mitral leaflet prolapse syndrome is not associated with regional myocardial ischemia as demonstrated with stress scintigraphy, and that stress scintigraphy, a noninvasive technique, is useful in distinguishing the mitral prolapse syndrome from mitral prolapse associated with coronary artery disease.
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PMID:Stress myocardial imaging in mitral leaflet prolapse syndrome. 70 87

3 patients with different clinical and electrocardiographic manifestations of coronary artery spasm are discussed. All 3 patients had anginal attacks at rest. In addition, 2 of these patients, who did not have significant preexisting narrowing of their coronary arteries, also had anginal pain related to exercise. During pain, 1 patient showed ST-segment elevation, the other ST-segment depression, while the third showed ST-segment depression shortly followed by ST-elevation on the electrocardiogram. At coronary angiography, spontaneous or induced spasm of one of the major coronary arteries could be demonstrated in all 3 patients. In 2 cases, sublingual nitroglycerin failed to completely relieve the spasm. This raises the question whether a residual stenosis after NTG conclusively proves a fixed organic narrowing. It is concluded that the clinical spectrum of spasm of the coronary arteries is wider than was originally reported by Prinzmetal and coworkers. Clinical and electrocardiographic manifestations are probably dependent on the site and severity of the spasm, which may cause different degrees of myocardial ischemia.
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PMID:Variant forms of angina pectoris. 71 Apr 90


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