Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An ability of high density lipoproteins HDL3 to accept cholesterol from erythrocyte membranes was studied in healthy persons and in patients with ischemic disease of heart. The cholesterol-acceptory function was estimated as follows: by incorporation of fluorescent probes (cholestatriene and pyrene) into particles of HDL3, by elimination of cholesterol from erythrocyte membranes and by increase of the lipoproteins size evaluated using the method of quazi-resilient dispersion of laser light. In ischemic disease of heart the property of high density lipoproteins, specifically of HDL3 fraction, to accept cholesterol from cell membranes was impaired. Middle size of HDL3 particles was decreased in the patients with ischemic heart disease as compared with that of healthy persons.
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PMID:[Impairment of cholesterol-acceptor function of high density lipoproteins in patients with ischemic heart disease]. 340 Jan 90

Distribution of high density lipoprotein (HDL) subfractions was studied by means of gradient ultracentrifugation depending on their hydration density and using electrophoresis in gradient polyacrylamide gel according to the particles size. 53 men were examined, where 43 patients were impaired with ischemic heart disease and with atherosclerosis of coronary arteries documented by angiography. In all the patients with ischemic heart disease and dislipoproteinemias distribution of the HDL particles was altered towards a decrease in amount of HDL2b particles; at the same time, loading with cholesterol of the HDL3 subfraction was lowered. The alterations in the subfraction spectrum and composition of HDL observed in the patients with the ischemia and coronary atherosclerosis appear to exhibit the atherogenous impairments in cholesterol elimination from arterial wall.
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PMID:[Distribution of subfractions of high-density lipoproteins during their separation according to hydrated density and particle size]. 370 22

Cholesterol levels in high density lipoprotein subfractions (HDL2 and HDL3) were evaluated in 69 patients (55 males, average age +/- SD 58.3 +/- 8.8, and 14 females, average age +/- SD 63.1 +/- 10.3) with extra-coronary arteriosclerosis (lower limbs, supraaortic trunks and both sites), and in 79 healthy age-matched control subjects. HDL cholesterol was significantly reduced in male and female patients. The HDL cholesterol decrease was due to a fall in both HDL2 and HDL3 cholesterols; nonetheless, an analysis of the HDL2-cholesterol/HDL3-cholesterol ratio disclosed that HDL2 cholesterol was the most reduced. Slightly higher plasma cholesterol and triglyceride levels were found in the patients as well as a higher plasma cholesterol/HDL-cholesterol ratio. On the contrary, the HDL2-cholesterol/HDL3-cholesterol ratio was significantly reduced in the patients. These preliminary findings suggest that, as in ischemic heart disease, the HDL cholesterol reduction in cerebral and peripheral arteriosclerosis is also mainly due to a reduction in the HDL2 subfraction. These results also lend further support to the proposal that determination of the HDL subfractions is useful for a better assessment of the risk profile for arteriosclerosis.
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PMID:Selective determination of cholesterol in high density lipoprotein subfractions (HDL2 and HDL3) in patients with cerebral and peripheral arteriosclerosis. 399 73

In men without any symptoms of ischemic heart disease, living in two different geographical zones (Moscow and Chuckchee land) low level of high density lipoprotein (HDL) cholesterol was accompanied by alterations in phospholipid composition of HDL2 and HDL3: decrease in the ration of lecithin and increase in sphingomyelin and kephalin content. The alteration in the phospholipid composition of these two HDL subclasses occurred simultaneously with changes in fatty acid composition of HDL lecithin: decrease in the ratio of linoleic acid as well as in stearic and arachidonic or eucosepentaenic acids. At the same time, phospholipid composition of the HDL subclasses was dissimilar in men and women without any symptoms of ischemic heart disease. Role of alterations in the fatty acid composition of phosphatide acid as well as effect of hormones on alterations in the phospholipid composition of HDL in hypoalphacholesterolemia are discussed.
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PMID:[Various reasons for changes in the phospholipid composition of high density lipoproteins in hypoalphacholesterolemia]. 402 25

Structural properties of lipoprotein organization in blood plasma of the patients with ischemic heart disease have been studied by means of electronic paramagnetic resonance method, using a derivate of stearic acid (5-doxylsteararte) as a spin probe. Significant differences in the patterns of thermo-induced structural reorganizations of all the lipoprotein types in normal and pathological states were shown. However, these differences were not found in the lipids isolated from the lipoproteins. In high density lipoproteins HDL2 and HDL3 from blood plasma of the patients with ischemic heart disease a decrease in the micro-environment polarity was shown to take place at the depth of 8 A from the lipoprotein surface. The data obtained suggest the distinct changes in structural organization of all the lipoprotein types in heart ischemic disease, which appear to occur as a result of modification of apoproteins and/or protein-lipid interactions in lipoproteins.
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PMID:[Characteristics of the structural organization of lipoproteins in the blood plasma of patients with ischemic heart disease using the spin probe method]. 609 93

Twenty-six postmenopausal women who had been on cutaneous oestradiol treatment for 3-6 months were given either 120 micrograms of 1-norgestrel (n = 13) or 300 mg of progesterone (n = 13) sequentially for another 6 months. The concentrations of cholesterol, phospholipids and triglycerides were determined in plasma and in the HDL, HDL2, HDL3, LDL and VLDL fractions before and after one, three and six cycles of progestin treatment. Already after 11 days on 1-norgestrel, the mean HDL cholesterol and the mean HDL phospholipid concentrations were reduced by 15%. The reduction of the HDL-lipids was mainly confined to the HDL2 fraction which was decreased by 25-30%. L-norgestrel also reduced the mean TG concentration both in the VLDL and the combined LDL + HDL fractions. Progesterone gave only minor changes of the plasma lipids and lipoproteins. Reduced HDL, especially HDL2, concentration, as induced by 1-norgestrel, might increase the risk for ischaemic heart disease. Therefore, it seems that, as regards the effects on the lipoproteins, progesterone might be more suitable than the 19-nortestosterone derivative 1-norgestrel for postmenopausal sequential hormonal therapy.
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PMID:L-norgestrel and progesterone have different influences on plasma lipoproteins. 641 61

To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial. In the men taking regular exercise serum cholesterol concentrations increased 26% more in the high density lipoprotein subfraction two (HDL2) and decreased 31% more in the subfraction three (HDL3) and 9% more in the low density lipoprotein fraction than in the control group. A tendency towards increased plasma 6-keto-prostaglandin F1 alpha concentration and decreased serum thromboxane B2 concentration was found during the period of regular exercise, but prostaglandin E2 concentrations remained unchanged. The increase in plasma 6-keto-prostaglandin F1 alpha concentration was associated with an increase in serum HDL2 cholesterol concentration in the group taking regular exercise. Our data suggest that mild regular physical exercise favourably influences cholesterol distribution in serum lipoproteins in healthy middle aged men and may have beneficial effects on circulating metabolites of arachidonic acid.
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PMID:Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men. 642 95

The serum HDL2-C, HDL3-C, apo AI and apo AII levels were measured in the non-insulin-dependent diabetic subjects (NIDD) and normal subjects to study the metabolism of HDL in the diabetics. The serum HDL2-C levels in the insulin-treated group were significantly higher than those in the normal group in which the total cholesterol (TC), triglyceride (TG), obesity index and age were matched whereas there was no difference between the serum HDL2-C levels in the oral agent-treated group or group treated by diet only and those in the normal group. These suggest that insulin increases the HDL2-C levels and the increase of the HDL2-C levels is not directly related to changes in the serum TC and TG levels, obesity index and age. No significant differences in the serum apo AI and apo AII levels were found between the insulin group and normal group. From these results it is suggested that in the insulin group the cholesterol/apoprotein ratio in the HDL2 is higher than that in the normal group. The serum apo AI and apo AII levels were significantly lower in the diabetics with an ischemic heart disease (IHD) than those in the diabetics without the IHD. The results show that in the diabetics the apo AI and apo AII play an important role in preventing the development of IHD.
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PMID:High density lipoprotein and diabetes mellitus. 643 May 82

A ratio cholesterol esters/apo B in very low and low density lipoproteins (VLDL and LDL), characterizing their cholesterol-transport function, as well as a ratio cholesterol esters/apo A-I in high density lipoproteins (HDL) HDL2 and HDL3, demonstrating the loading of cholesterol per unit of their main protein, were studied in 16 patients with ischemic heart disease accompanied by coronary atherosclerosis documented by angiography and in 36 healthy men. In patients with coronary atherosclerosis and low level of HDL cholesterol, particles of atherogenic lipoproteins were overloaded with cholesterol esters, while the ratio cholesterol esters/apo A-I was decreased in HDL2 and HDL3 as compared with controls. These alterations might be related to an increase in efficiency of cholesterol esters transport from HDL into VLDL and LDL as a result of dissimilar transformations in chemical and structural characteristics of surface monolayer of VLDL and HDL particles studied earlier.
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PMID:[Disruption of the cholesterol-transport function of lipoproteins in the blood plasma of patients with ischemic heart disease]. 652 38

It is shown that the modifying ability sequence of human plasma lipoproteins from patients with ischemic heart disease (IHD) in respect to BLM made of oxidized cholesterol is [HDL2] less than [LDL] less than [VLDL] less than [HDL3] and differs from that in healthy people which is [VLDL], [LDL] less than [HDL2] less than [HDL3]. It is suggested that changes in lipid-protein compositions of the lipoproteins in the case of IHD determined the alterations of the nonreceptor interactions of the atherogenic and antiatherogenic lipoprotein classes with the cell membranes.
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PMID:[Peculiarities of interactions of bilayer lipid membranes with human plasma lipoproteins from patients with ischemic heart disease]. 706 91


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