Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors conducted a comparative study of various methods of coronary shunting by means of microsurgical techniques in 240 patients who were operated on for ischemic heart disease. Total myocardial revascularization, including arteries measuring less than 1.5 mm in diameter and vessels in the zones of cardiosclerosis, was found to be more effective than the techniques of shunting of only the affected major branches. The advantages of a mammary-coronary shunt over anauto- logous venous shunt in reconstruction of coronary arteries under unfavourable hemodynamic conditions are demonstrated. It is also shown that multiple bi-mammary-coronary shunting of the branches of the left coronary artery is a promising method.
 ...
PMID:[Current trends in the development of coronary surgery]. 191 Sep 2

Examined were 98 patients with chronic forms of ischemic heart disease, mainly atherosclerotic cardiosclerosis with different degrees of cardiac insufficiency. Two groups were distinguished. Patients of the first group received traditional treatment while patients of the second group received also nicotinic acid agents. It was found that inclusion of nicotinic acid in the complex treatment of patients with ischemic heart disease increased the therapeutic efficacy.
 ...
PMID:[Nicotinic acid in the treatment of chronic circulatory failure in patients with ischemic heart disease]. 260 11

Quantitative histochemical assays of several enzymes (succinic, lactic, beta-hydroxybutyrate, alpha-glycerophosphate, and glucose-6-phosphate dehydrogenases, NAD diaphorase, and phosphorylase) in the myocardium of persons who had died suddenly with postinfarctional cardiosclerosis have failed to reveal any changes specific for this patient group. Direct correlations were established between the enzyme activities assayed, on the one hand, and the extent of myocardial hypertrophy and the signs of chronic heart failure, on the other. The activities of beta-hydroxybutyrate dehydrogenase and glucose-6-phosphate dehydrogenase, which are involved in fatty acid utilization and in the pentose phosphate pathway, were elevated in cases of moderate hypertrophy, as were those of all redox enzymes in cases of strongly marked hypertrophy, although they were reduced in cases with signs of chronic cardiac failure despite the presence of considerable myocardial hypertrophy. Areas of acute myocardial ischemia were discovered in 45% of the cases.
 ...
PMID:[Histochemical study of the enzyme activity of the myocardium of sudden death victims with postinfarct cardiosclerosis]. 296 Feb 98

The circadian rhythm of certain functional indicators of the cardiovascular system was investigated in 141 patients with ischaemic heart disease (IHD), of whom 65 had post-infarction cardiosclerosis and in 26 healthy subjects. The obtained data were processed by an ES-1020 computer according to a special "Cosinor" programme. Specific circadian rhythm was determined of certain haemodynamic indicators, sinus node excitability, impulse conduction, myocardial supply (according to ECG data) and of the blood clotting system. In healthy subjects, the coincidence of the acrophases of circadian rhythms of functional indicators of the cardiovascular system was found; these indicators reached their maximum level during the day and in the evening. In patients with IHD (with prior myocardial infarction as well as without), there were found shifts in the circadian rhythm of bioelectrical processes in the myocardium, with the maximum values shifted to the night and morning hours. These shifts are a consequence of changes in myocardial nutrition and of worsened coronary flow during the day and in the early evening hours, when the patients exhibit also a tendency towards increased activity of the blood clotting system, as well as fibrinolysis depression.
 ...
PMID:Comparative analysis of circadian rhythms of certain functional indicators of the cardiovascular system in healthy subjects and in patients with ischaemic heart disease. 647 44

Immediate and delayed type immune response was studied in 374 patients with ischemic heart disease (myocardial infarction in 242, preinfarction state in 32, postinfarction cardiosclerosis in 100). Immediate and delayed type hypersensitivity was recorded with the highest frequency in patients with myocardial infarction and least frequency in patients with postinfarction cardiosclerosis. It was shown that humoral and cellular immune response can be used in assessing the severity of myocardial infarction and prognosing its complications, autoimmune genesis, in particular.
 ...
PMID:[Clinical and immunological parallels in ischemic heart disease]. 725 90

An investigation into the renin-angiotensin-aldosterone system (RAAS) in patients of advanced age with ischaemic heart disease (IHD) and different degrees of atherosclerotic cardiosclerosis by means of radioimmunoassay, which was used to determine the renin activity and the aldosterone concentration in the plasma, showed that there is in IHD an activation of the above regulatory system even under the conditions of relative rest. Furthermore, it was found out that the renin activity of the plasma was increased only in male patients with IHD, whereas the aldosterone concentration was increased both in males and females. These findings justify the hypothesis on the pathogenetic role played by changes in the RAAS in IHD in old age. The more severe disorders of the RAAS as seen in male patients with IHD explain to some extent the earlier onset and greater severity of IHD in men. For the treatment of hyperaldosteronism, which has been found to be associated with IHD in persons of advanced age, it is necessary to include into the therapeutic plan of patients with IHD, in particular males, competitive aldosterone antagonists as well as beta-adrenergic blocking agents.
 ...
PMID:[Peculiarities of the renin-angiotensin-aldosterone-system in elderly patients with ischaemic heart diseases (author's transl)]. 733 79

Total cholesterol and triglycerides as well as their distribution among the different hyperlipoproteinemia types were studied in three patients groups: 47 normotensive patients with myocardial infarction, 35 normotensive patients with cardiosclerosis (chronic ischemic heart disease), 29 hypertensive patients without symptoms or signs of clinical atherosclerosis. Their results were compared to those of 45 normal controls. There was no decrease in HDL cholesterol nor increase in LDL cholesterol in patients with chronic or acute ischemic heart disease. A large percentage of patients from these groups had normolipoproteinemia. The most prominent lipidic changes were observed in hypertensive patients: no patient had a HDL cholesterol level above normal values, thirty three per cent had a HDL cholesterol level below 35 mg/dl. A high percentage of patients with acute myocardial infarction or hypertension exhibited atypical lipoproteinemia anomalies (hyper HDL triglyceridemia, hyper LDL triglyceridemia, hyper VLDL cholesterolemia) when they could have normolipoproteinemia. This suggested lipoproteinic metabolism disturbances in such cases.
 ...
PMID:[Changes in serum lipid levels, lipid composition and lipoprotein fractions in patients with ischemic cardiopathies or arterial hypertension]. 733 37

Three corrected orthogonal leads are compared with 12 standard ECG leads. The method of restoration of the leads was used by means of which 12 standard leads are first restored from 3 corrected leads after which a diagnosis is made separately from the natural and the restored leads. To reduce the effect of subjectivism to the minimum, the Minnesota code criteria was used in the diagnosis. The ECG of 153 patients with ischemic heart disease and post-infarction cardiosclerosis and the ECG of 50 practically healthy individuals were anlayzed. The analysis showed that the diagnosis of cicatricial changes consequent upon infarction of the anterior myocardial wall according to restored leads was inferior by 6.6% to the diagnosis made from the 12 natural leads; the diagnosis of infarction of the posterior wall of the left ventricular myocardium as well as of infarction of anteroposterior localization may be made with the same precision as when made from 12 standard leads.
 ...
PMID:[Comparison of corrected orthogonal leads with standard ones using the Minnesota code criteria]. 737 90

Echocardiography was conducted in 169 patients with ischemic heart disease (atherosclerotic and postinfarction cardiosclerosis, angina pectoris, unstable angina pectoris, myocardial infarction) to determine the diagnostic importance of changes in the contractile function of the interventricular septum (IVS). It is shown that no essential changes in IVS contractility detectable by echocardiography are encountered in patients with ischemic heart disease in a period clear of exacerbation. During an attack of angina pectoris, a decrease of the mean normalized rate of IVS systolic displacement is recorded, which suggests indirectly a lesion of the left anterior descending artery. IVS contractile function increases in the pre-infarction period, which is a compensatory reaction to the changes in the contractile function of the left ventricle.
 ...
PMID:[Diagnostic significance of a change in the contractile function of the interventricular septum in ischemic heart disease (based on echocardiographic data)]. 737 1

The authors have performed 631 urgent suprapubic transvesical adenomectomies in patients with prostate adenoma complicated by acute urine retention or hemorrhage. Prearranged and urgent interventions had, by the authors' experience, virtually the same rate of postoperative complications and lethal outcomes. The risk in urgent adenomectomy performed in 294 patients was attributed to their concurrent affections: postinfarction cardiosclerosis, myocardial ischemia or hypertensive crisis, hemiparesis after brain apoplexy, bronchial asthma, diabetes mellitus, hepatic cirrhosis, chronic lymphoid leukemia, drug polyallergy, multiple tumors of the urinary bladder, stomach, etc., in stage T1-3NOMO. 80 patients had intermittent chronic renal failure. In compensation of severe concurrent diseases and satisfactory condition of the patients urgent adenomectomy was conducted within 24 hours since hospitalization. Longer interval (within 24-72 hours) was necessary in subcompensation of the concurrent diseases, intermittent chronic renal failure which were intensively treated. The authors achieved uneventful postoperative course for 272 (92.5%) high-risk patients. Postoperative lethality made up 3.06%. According to 1-11-year follow-up 7 patients died, for the most part of blood and respiratory diseases. Functional long-term outcomes were good in 83.5% of the patients. Basing on their experience, the authors specify indications to urgent adenomectomy and optimal time of its conduction. Contraindications to urgent adenomectomy were revised and narrowed.
 ...
PMID:[The indications and contraindications for emergency adenomectomy in patients with severe concomitant diseases]. 753 45


<< Previous 1 2 3 4 5 6 7 Next >>