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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The circadian rhythms of the functions of the cellular components of haemostasis, and their response to administration of ACTH, were studied in 30 healthy volunteers and in 17 patients with cardiosclerosis secondary to past myocardial infarction. A biphasic periodicity was found of the counts and functional activities of thrombocytes and basophilic leukocytes during 24-h periods. The phase of peak activities of both formed blood elements was established between 11.00 and 14.00 hours; in the night their functional capacities were lower than in the morning. Administration of ACTH elicited analogous shifts in the above mentioned indicators, but with a faster development of the first phase. In ischaemic heart disease the normal circadian rhythm of functions of the specified indicators was disturbed, and they exhibited signs of inertia, which phenomenon, in the author's opinion, reflects a lowered reliability of function of the haemostatic system.
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PMID:Circadian rhythms of the functions of thrombocytes and basophils in the blood of healthy volunteers and of patients with ischaemic heart disease. 21 72

Stereometric studies showed that the volumetric portion of diffuse stromagenic cardiosclerosis in the myocardium increased in parallel with the prolongation of the course of ischemic heart disease and with an increase in the average values of atherosclerotic involvement of the intima of coronary arteries and was inversely related to the index of retention of the total summary functioning lumen of the coronary arteries. There is a direct correlative relationship between the degree of narrowing of the summary functioning lumen and the intensity of stromagenic cardiosclerosis, increasing with the prolongation of the course of the disease.
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PMID:[Correlative relationship between coronary arteriosclerosis and stromogenic cardiosclerosis in ischemic heart disease (stereometric study)]. 36 22

The results of the examination (electrocardiography, selective coronary arteriography, and left ventriculography) of 100 patients with ischemic heart disease and a history of myocardial infarction are discussed. All patients with postinfarction cicatricial changes in the myocardium of the anterior wall had severe affection (occlusion or stenosis by more than 75%) of the anterior interventricular branch of the left coronary artery, while 93% of patients with cicatricial changes in the myocardium of the inferior wall had affection of the right coronary artery. The parameters of myocardial contractility (ejection fraction, left ventricular and diastolic pressure, and Vmax) in patients with microfocal postinfarction cardiosclerosis both of the anterior and the inferior walls and in patients with macrofocal cardiosclerosis of the inferior wall remain within the lowest normal level. The contractility of the myocardium is sharply impaired in patients with macrofocal cardiosclerosis of the anterior wall and in those with combined cardiosclerosis of the anterior and inferior walls.
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PMID:[Myocardial contractile function in ischemic heart disease patients who have had a myocardial infarct]. 43 8

Blood rheology was studied in 92 patients with ischemic heart disease having cardiac rhythm disorders. The syndrome of high blood viscosity and increased blood platelets aggregation were observed in paroxysmal tachycardia. In patients suffering from myocardial infarction with arrhythmia there was noted higher blood viscosity and more intensive blood platelet aggregation than in atherosclerotic cardiosclerosis. Treatment of paroxysmal tachycardia by means of electric impulse and agents blocking beta-adrenergic receptors results in a decrease of blood viscosity, the blood platelets aggregation intensity being unchanged.
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PMID:[Heart rhythm disorders and blood rehology in ischemic heart disease]. 62 50

The informative value of functional tests (with inderal, potassium and bicycle ergometer), the state of central hemodynamics, and the effectiveness of the anabolic hormone retabolil were studied in young females with dyshormonal myocardial dystrophy. The group consisted of 33 females between the ages of 33 and 45 with maintained menstrual cycle. The presence of cardialgia, syndrome of negative T wave, aggravated gynecologic anamnesis and the absence of clinical and laboratory data testifying to coronarogenous, inflammatory or some other lesion of the heart muscle made it possible to make the diagnosis of dyshormonal myocardial dystrophy. Functional tests with inderal and potassium and bicycle ergometry are objective criteria in the differential diagnosis of ischemic heart disease and dyshormonal myocardial dystrophy. Negative drug tests in individuals with persistent signs of dyshormonal dystrophy of the myocardium are evidence in favour of the development of postdystrophic cardiosclerosis. According to the data of hemodynamics, the functional state of the myocardium in patients with diffuse myocardial dystrophy is impaired. The anabolic hormone retabolil is an agent of pathogenetic therapy in the group of patients studied.
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PMID:[Differential diagnosis and treatment of ischemic heart disease and dyshormonal myocardial dystrophy]. 67 91

Modern clinicians encounter considerable difficulties in the diagnosis and treatment of ischemic heart disease which is first of all due to insufficient knowledge of the main mechanisms of the development of coronary insufficiency, myocardial dystrophy, myocardial necrosis, and cardiosclerosis. From the point of view of molecular cardiology, myocardial hypoxia cannot be considered as the foundation for ischemic disease. Metabolic insufficiency of the heart both of coronary and non-coronary origin should also be taken into account. Apart from ischemic (coronary) disease, ischemia of the myocardium alongside with metabolic disorders occurs in most diverse conditions and diseases. Therefore, in future this diagnosis will be reconsidered towards a more accurate determination of the causes of these disorders. Examples from clinical practice are presented for the discussion os such causes and mechanisms. A classification of the causes of metabolic heart deficiency and its outcomes is proposed.
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PMID:[Pathogenesis and classification of ischemic heart disease]. 68

Under observation were kept 80 patients with signs pointing to the sick sinus syndrome. Most of them suffered from ischemic heart disease, from atherosclerotic cardiosclerosis and acute myocardial infarction. Persistent sinus bradycardia with active and passive heterotopic arrhythmias were recorded in 42 patients. Sino-auricular block of the II and III degrees or asystolia of the atria with ectopic arrhythmias were observed in 37 cases. A number of patients displayed fibrillary bradyarrhythmia, extrasystole with post-extrasystolic depression of the rhythm and other disturbances. The so-called tachycardia-bradycardia syndrome characterized by the presence of tachycardiac arrhythmias occurring against the background of a marked bradycardia was registered in 25 persons. Fifteen patients demonstrated attackes of the Morgagni-Adams-Stokes syndrome, usually associated with lengthy periods of cardiac asystole. The treatment of ectopic arrhythmias in patients with the sick sinus syndrome presents considerable difficulties, but in many of them these disorders could be successfully eliminated by a careful and rigidly controlled application of antiarrhythmic agents (isoptin, ajmalin, pulsnorma, rhythmodan, beta-adrenergical blocking agents). For some patients exhibiting a tendency toward asystole electric stimulation of the heart is indicated.
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PMID:[Syndrome of sino-atrial node asthenia]. 79 80

The life-span of methionie-Se75-labelled thrombocytes was studied in 46 patients with ischaemic heart disease and in 5 control individuals. In ischaemic heart disease patients the platelets life-span comprised 6.6+/-0.14 days, this period being smaller in patients over 60 years of age and in males, in contrast to younger patients and females. The presence of arterial hypertension and excessive body weight did not affect the life-span of the thrombocytes. Smoking, hypercholesterolemia and hypertriglyceridemia caused a statistically significant reduction of the circulation time of labelled thrombocytes. In patients with frequent attacks of angina pectoris and with postinfarction cardiosclerosis the life time of the platelets was shorter then in patients with painless forms of the disease and in those free of myocardial infarction. In Type II hyperlipoproteidemia the circulation period of labelled platelets comprised 6.3+/-0.16 days; in Type IV -- 6.7+/-0.29 days and in normolipemia -- 7.4+/-0.30 days. A distinct inverse correlation was established between the blood plasma cholesterol and thriglycerids level and the thrombocytes life-span. It was concluded that the reduction of the life-span of thrombocytes is attributed to the consumption of platelets by the processes of atherogenesis and chronic intravascular thrombus formation.
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PMID:[Types of hyperlipoproteinemia and thrombocyte survival in ischemic heart disease]. 88 45

The indices of contractility of the left ventricular myocardium were studied by means of ventriculography and catheterization in 84 patients with ischemic heart disease according to the extent of damage to the coronary arteries and the course of the disease. Changes in the coronary arteries were encountered twice as frequently among patients with postinfarction cardiosclerosis as among patients with angina pectoris and no history of infarction. The main cause of disorders of myocardial contractility in patients with ischemic heart disease is post-infarction cardiosclerosis (56% of cases). Signs of impaired functional capacity of the left ventricle appeared in segmental asynergy involving 20 to 25% of its circumference. Changes in the indices of contractility were revealed in 13% of patients with angina pectoris.
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PMID:[Myocardial contraction in ischemic heart disease]. 92 72

The article deals with the data of echocardiographic examination of 61 patients (37 with rheumatic heart disease and 17 with atherosclerotic cardiosclerosis) subjected to rapid stage-by-stage digitalization by intravenous administration of various rapidly acting glycosides. In 10 patients with ischemic heart disease echocardiography was performed following a single strophanthin injection. Decrease in the volumes of the left ventricle and increase in the indices of central hemodynamics were noted as a result of rapid stage-by-stage saturation with strophanthin. The maximum inotropic effect of strophanthin does not coincide in time with the maximum chronotropic effect. The increase in the stroke volume noted in maximum deceleration of cardiac contractions is probably realized due to the Frank-Starling mechanism. Strophanthin increases the rate of myocardial contractions without changing the duration of the systole. The rate of diastolic relaxation grows, the phase of rapid filling becomes shorter and the phase of slow filling longer, which creates favourable conditions for the next contraction.
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PMID:[Effect of rapid digitalization on the left-ventricular myocardial function according to the echocardiographic data]. 92


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