Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The finding of low plasma pyridoxal-5'-phosphate levels in patients suffering from myocardial infarction has been construed as possible evidence for the pathogenetic role that vitamin B6 deficiency may play in causing premature ischaemic heart disease. However, the presence of normal plasma pyridoxal-5'-phosphate levels in patients with angiographic evidence of coronary artery narrowing but with no previous infarctions prompted the investigation of possible short-term alterations in plasma pyridoxal-5'-phosphate levels during the acute phase of myocardial infarction. In the follow-up of 30 patients with acute myocardial infarction, all of them showed a continuous decrease of approximately 45% in plasma pyridoxal-5'-phosphate levels during the acute phase. These levels subsequently returned back to normal before discharge from hospital. A large number of volunteers from an ethnic group known to have a very low incidence of ischaemic heart disease were found to have both significantly lower total cholesterol and plasma pyridoxal-5'-phosphate levels than a Caucasian group in the same geographic area which is known to have a high incidence of ischaemic heart disease. These findings therefore do not support the contention that vitamin B6 deficiency may be a risk index for ischaemic heart disease.
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PMID:Vitamin B6 and coronary artery disease. Epidemiological observations and case studies. 382 84

The 'vitamin B6-homocysteine theory' has been proposed as an alternative to the widely accepted lipid hypothesis in the aetiology of ischaemic heart disease (IHD). In a cross-sectional study of 71 white men with evidence of IHD and 110 male controls (all aged 45-54 years) we have been unable to demonstrate any differences in plasma pyridoxal phosphate (PLP) levels between the groups. It is therefore unlikely that deficiency of vitamin B6 has a primary causal role in development of IHD. However, 31% of the overall study population had low plasma PLP levels, and the possibility that underlying vitamin B6 deficiency may facilitate the actions of the primary risk factors for IHD therefore cannot be excluded.
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PMID:Lack of a relationship between plasma pyridoxal phosphate levels and ischaemic heart disease. 399 78